Heterogeneity in cancer stem cells

• 作者： Wang, Anxin ¹ Chen, Lisha ¹ Li, Chunlin ¹ Zhu, Yimin ¹ Wang, Anxin ² Chen, Lisha ² Li, Chunlin ² Wang, Anxin ³ Chen, Lisha ³ Li, Chunlin ³
• 作者单位：
  1.  Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Div Nanobiomed, Key Lab Nanobio Interface Res,Suzhou Key Lab Nano, Suzhou 215123, Peoples R China.
  2.  Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China.
  3.  Univ Chinese Acad Sci, Being 100049, Peoples R China.
• 提交时间：2016-05-11

摘要: Accumulating evidence suggests that cancer stem cells (CSCs) are heterogeneous populations and their phenotypes are unstable. A number of intrinsic and extrinsic mechanisms contribute to CSC phenotypic variation. The existence of various CSC subpopulations which would lead to a rapid relapse after primary treatments might pose a problem for CSC targeted therapeutics. In order to develop more effective approaches to cancer therapeutics, more CSC-related surface markers or targeting molecules, as well as some novel targeting strategies should be explored. This review summarized the origin and performance of heterogeneity in CSCs and discussed their therapeutic implications. (c) 2014 Elsevier Ireland Ltd. All rights reserved.

• 期刊： CANCER LETTERS
• 分类： 生物学 >> 生物物理学 >> 肿瘤学
• 引用： ChinaXiv:201605.01187 (或此版本 ChinaXiv:201605.01187V1)
  doi:10.12074/201605.01187
  CSTR:32003.36.ChinaXiv.201605.01187.V1
• 推荐引用方式： Wang, Anxin,Chen, Lisha,Li, Chunlin,Zhu, Yimin,Wang, Anxin,Chen, Lisha,Li, Chunlin,Wang, Anxin,Chen, Lisha,Li, Chunlin.(2016).Heterogeneity in cancer stem cells.CANCER LETTERS.[ChinaXiv:201605.01187] (点此复制)