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On the origin of SARS-CoV-2–The blind watchmaker argument

Submit Time: 2021-07-17
Author: Chung-I Wu 1 ; Haijun Wen 1 ; Jian Lu 2 ; Xiao-dong Su 2 ; Alice C. Hughes 3 ; Weiwei Zhai 4 ; Chen Chen 5 ; Hua Chen 6 ; Mingkun Li 6 ; Shuhui Song 6 ; Zhaohui Qian 7 ; Qihui Wang 8 ; Bingjie Chen 1 ; Zixiao Guo 1 ; Yongsen Ruan 1 ; Xuemei Lu 9 ; Fuwen Wei 10 ; Li Jin 11 ; Le Kang 12 ; Yongbiao Xue 6 ; Guoping Zhao 13 ; Ya-Ping Zhang 9 ;
Institute: 1.State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China; 2.State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, School of Life Sciences, Peking University, Beijing 100871, China; 3.Landscape Ecology Group, Center for Integrative Conservation, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Mengla, Yunnan 666303, China; 4.Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; 5.Biomedical inovation center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China; 6.Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Centre for Bioinformation, Beijing 100101, China; 7.Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100176, China; 8.CAS Key Laboratory of Pathogen Microbiology and Immunoly, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; 9.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, China; 10.CAS Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; 11.MOE Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China; 12.State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; 13.Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China;


In the comparison with SARS-CoV of 2003, SARS-CoV-2 is extremely well adapted to the human populations and its adaptive shift from the animal host to humans must have been even more extensive. By the blind watchmaker argument, such an adaptive shift can only happen prior to the onset of the current pandemic and with the aid of step-by-step selection. In this view, SARS-CoV-2 could not have possibly evolved in an animal market in a big city and even less likely in a laboratory. Discussions of the origin of SARS-CoV-2 need to factor in the long process of adaptive shift and some models have indeed advanced in that direction.
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From: 刘静羽
Keywords: SARS-CoV-2;
Recommended references: Chung-I Wu,Haijun Wen,Jian Lu,Xiao-dong Su,Alice C. Hughes,Weiwei Zhai,Chen Chen,Hua Chen,Mingkun Li,Shuhui Song,Zhaohui Qian,Qihui Wang,Bingjie Chen,Zixiao Guo,Yongsen Ruan,Xuemei Lu,Fuwen Wei,Li Jin,Le Kang,Yongbiao Xue,Guoping Zhao,Ya-Ping Zhang.(2021).On the origin of SARS-CoV-2–The blind watchmaker argument.[ChinaXiv:202107.00013] (Click&Copy)
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[V1] 2021-07-17 13:58:53 chinaXiv:202107.00013V1 Download
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