TLD calibration and absorbed dose measurement in a radiation-induced liver injury model under a linear accelerator
摘要: 应用热释光探测器（TLD）检测直线加速器精确放疗下小鼠肝脏照射部位的剂量，并采用单次高剂量照射小鼠肝脏的方法，构建小鼠辐射诱发肝损伤（RILD）的生物模型，以确定在直线加速器下构建小动物精确放疗模型的可行性。在固体水内TLD的位置为计划中的靶体积（PTV）制定了360弧形旋转调强放疗（VMAT）计划，规定剂量为2Gy，以比较TLD的测量剂量与TPS系统中评估参数的差异。将TLD植入小鼠肝脏，并根据TLD计划VMAT，以比较测量和规定的剂量。C57BL/6J小鼠被随机分为对照组和25Gy辐射组，每天检查体重的变化。它们在辐射后3周和10周被安乐死，并测量肝脏血清酶的水平，如丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）和碱性磷酸酶（ALP），观察小鼠肝脏受照射区域的任何病理组织学变化。固体水下TLD的测量值在TPS系统中评价参数的Dmean值的3%以内。25Gy辐射组的小鼠在肝脏照射部位表现出辐射引起的肝脏损伤的病理迹象。小鼠肝脏中TLD的测量剂量和规定剂量的偏差在-1.5%至6%之间；在直线加速器下使用VMAT技术构建RILD的精确模型是可行的。
Abstract: The application of a thermoluminescent detector (TLD) for dose detection at the liver irradiation site in mice under linear accelerator precision radiotherapy and the use of a single high dose to irradiate the mouse liver to construct a biological model of a radiation-induced liver injury (RILD) in mice, in order to determine the feasibility of constructing a precision radiotherapy model in small animals under a linear accelerator. A 360 arc volumetric rotational intensity-modulated radiotherapy (VMAT) plan with a prescribed dose of 2 Gy was developed for the planned target volume (PTV) at the location of the TLD within solid water to compare the difference between the measured dose of TLD and the assessed parameters in the TPS system. The TLD was implanted in the livers of mice, and VMAT was planned based on TLD to compare the measured and prescribed doses. C57BL/6J mice were randomly divided into control and 25 Gy radiation groups, and were examined daily for changes in body weight. they were euthanized at 3 and 10 weeks after radiation, and the levels of liver serum enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were measured to observe any pathological histological changes in the irradiated areas of the mouse liver. The measured values of solid underwater TLD were within 3% of the Dmean value of the evaluation parameter in the TPS system. The mice in the 25 Gy radiation group demonstrated pathological signs of radiation-induced liver injury at the site of liver irradiation. The deviation in the measured and prescribed doses of TLD in the mouse liver ranged from 1.5% to 6%; construction of an accurate model of RILD using the VMAT technique under a linear accelerator is feasible.
| [V1] | 2023-06-01 16:31:01 | ChinaXiv:202306.00015V1 | 下载全文 |
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