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1. chinaXiv:202109.00031 [pdf]

黄土丘陵区典型人工林的根系分布特征

李浩
Subjects: Biology >> Botany

根系是植物吸收水分和养分的主要器官,发育及分布情况对植物生长具有极其重要的影响。本研究以甘肃省定西市安定区龙滩流域的人工白杨林、油松林以及山杏林为研究对象,分析了3种人工林总根及不同径级的根长、根面积、根生物量密度的垂直分布特征及其与土壤理化性质之间的关系,旨在从根系分布角度比较黄土丘陵区典型人工林之间的生长差异,为该区域植被恢复与评价提供一定的科学依据。研究结果显示:(1)不同径级的根系分布中3种人工林均以细根为主,细根与总根的根长及根面积密度均表现为白杨林>油松林>山杏林,根生物量密度表现为油松林>白杨林>山杏林,而中根与粗根的根长及根面积密度均以油松林为最高。(2)垂直土壤剖面上,3种人工林总根与细根的根长、根面积及根生物量密度整体上呈现出随土壤深度的增加而减少的趋势,而中根与粗根的垂直分布规律并不明显。(3)细根和总根的根长密度、根面积密度、根生物量密度与土壤全碳、全氮、有机碳及含水量均呈极显著正相关关系,中根的根长及根面积密度与土壤全碳、全氮、全磷及有机碳含量呈显著相关关系,粗根的根长及根面积密度与土壤全碳呈显著相关关系,土壤碳氮含量以及含水量的增加与林木根系的生长在一定程度上存在协同效应。

submitted time 2021-09-14 From cooperative journals:《干旱区研究》 Hits4815Downloads258 Comment 0

2. chinaXiv:202102.00050 [pdf]

半干旱黄土丘陵区退化人工林群落结构 调整下细根特征分析

李浩
Subjects: Biology >> Ecology

根系尤其细根在植物的生长发育中起着重要作用,以甘肃省定西市巉口镇龙滩流域的白 杨及山杏 2 种典型退化人工林为研究对象,研究了人工林群落结构调整后形成的白杨+5 年生油 松、白杨+10 年生油松及山杏+云杉、山杏+樟子松混交林与单一纯林相比不同深度、不同径级下细 根的根长密度、根面积密度、根生物量密度、比根长及比根面积,以期揭示不同人工林恢复模式下 的细根分布特征。结果表明:(1)混交恢复模式起到了一定的积极作用,大部分混交林相较于纯林 细根的根长密度、根面积密度及根生物量密度在土壤表层均有所提高。混交林细根在浅层的占比 得到了提高,且随恢复年限的增加而升高。(2)细根根长密度、根面积密度及根生物量密度与土壤 全碳、全氮、含水量及有机碳之间以及比根长及比根面积与土壤全碳、土壤全氮及有机碳之间均存 在显著正相关关系。

submitted time 2021-02-13 From cooperative journals:《干旱区地理》 Hits1913Downloads665 Comment 0

3. chinaXiv:202003.00008 [pdf]

Germline Polymorphisms and Length of Survival of Nasopharyngeal Carcinoma: An Exome-Wide Association Study in Multiple Cohorts

Yun-Miao Guo; Jie-Rong Chen; Yan-Chun Feng; Chua, Melvin L. K. ; Zeng, Yanni ; Edwin Pun Hui; Allen K. C. Chan; Lin-Quan Tang; Lin Wang; Qian Cui; Hui-Qiong Han; Chun-Ling Luo; Guo-Wang Lin; Yan Liang; Yang Liu; Zhong-Lian He; Yu-Xiang Liu; Pan-Pan Wei; Chu-Jun Liu; Wan Peng
Subjects: Medicine, Pharmacy >> Clinical Medicine

Germline polymorphisms have been linked with differential survival outcomes in cancers but have not been well studied in nasopharyngeal carcinoma (NPC). Here, two-phase association study is conducted to discover germline polymorphisms that are associated with the prognosis of NPC. The discovery phase includes two consecutive hospital cohorts of patients with NPC from Southern China. Exome-wide genotypes at 246,173 single nucleotide polymorphisms (SNPs) are determined, followed by survival analysis for each SNP under Cox proportional hazards regression model. Candidate SNP is replicated in another two independent cohorts from Southern China and Singapore. Meta-analysis of all samples (n = 5,553) confirm that the presence of rs1131636-T, located in the 3′-UTR of RPA1, confers an inferior overall survival (HR = 1.33, 95% CI = 1.20-1.47, P = 6.31 × 10-8). Bioinformatics and biological assays show that rs1131636 has regulatory effects on upstream RPA1. Functional studies further demonstrate that RPA1 promoted the growth, invasion, migration, and radioresistance of NPC cells. Additionally, miR-1253 has been identified as a suppressor for RPA1 expression, likely through regulation of its binding affinity to rs1131636 locus. Collectively, these findings provide a promising biomarker aiding in stratifying patients with poor survival, as well as a potential drug target for NPC.

submitted time 2020-03-06 Hits37626Downloads2510 Comment 0

4. chinaXiv:201712.00939 [pdf]

内窥镜获取大隐静脉在冠状动脉旁路移植术中的中期效果分析

张伟华; 李杰; 张新; 罗鸿; 马宁; 刘东海; 乔晨晖; 李继峰; 朱耀斌
Subjects: Medicine, Pharmacy >> Preclinical Medicine

目的 探讨内窥镜获取大隐静脉在冠状动脉旁路移植术中的中期临床效果。方法 选取2012年7月~2013年4月在郑州大学第一附属医院心外科接受不停跳冠状动脉旁路移植术的205例患者为研究对象。内窥镜获取大隐静脉(EVH)66例为研究组,男性35例,女性31例,年龄60.30±7.92岁,体质量69.77±10.66 kg;同期行开放获取大隐静脉(OVH)的139例为对照组,男性109例,女性30例,年龄59.20±8.37 岁,体质量71.16±9.91 kg。结果 205例患者均顺利完成手术。EVH组围术期死亡2例,死亡率为3.03%;OVH组死亡5例,死亡率为3.60%,两组围术期死亡率差异无统计学意义(P=1.00)。OVH组围术期发生急性心梗3例,发生率为2.16%,EVH组1例,发生率1.52%,亦无统计学差异;低心排综合征OVH组4例(2.88%),EVH组2例(3.03%),无统计学差异。术后随访 OVH组有 8例再发心绞痛,发生率为 8.80%;EVH组 5例,发生率为 8.06%,差异无统计学意义(P=0.93)。两组患者随访期间均无再发心梗;2年静脉桥血管通畅率,OVH组为83.59%,EVH组为82.22%,差异也无统计学意义(P=0.73)。结论 EVH在减低术后下肢伤口并发症上具有明显的优势,中期通畅率同常规手术组无统计学差异,而远期临床效果仍需进一步临床随访研究。

submitted time 2017-12-27 From cooperative journals:《南方医科大学学报》 Hits1465Downloads830 Comment 0

5. chinaXiv:201712.00272 [pdf]

桂附地黄丸干预阳虚体质的血浆代谢组学

肖雅; 经媛; 陈洁瑜; 李斐; 程静茹; 毕建璐; 罗仁; 赵晓山
Subjects: Medicine, Pharmacy >> Preclinical Medicine

目的 评价桂附地黄丸干预阳虚体质的临床疗效和探讨桂附地黄丸干预阳虚体质的疗效机制。方法 纳入健康和亚健康人群阳虚体质62例,以排除疾病对体质的影响,将阳虚体质随机分成两组,每组31例,对照组给予生活方式指导,试验组在生活方式指导的基础上给予桂附地黄丸干预1个月,评价研究对象的阳虚体质评分;应用核磁共振(NMR)技术方法对阳虚体质干预前后血浆进行代谢组学分析,采用多元统计分析方法寻找阳虚体质干预前后血浆内源性差异代谢产物。结果 试验组干预1个月后阳虚体质转化分较对照组显著下降(P<0.05);代谢组学结果表明生活方式干预后可提高阳虚体质血液中乳酸、缬氨酸、脯氨酸、3-羟基丁酸、精氨酸的含量。在生活方式指导的基础上给予桂附地黄丸干预除了提高阳虚体质血液中乳酸、缬氨酸、脯氨酸、3-羟基丁酸、精氨酸含量外,还可提高丙氨酸、谷氨酰胺、α-葡萄糖、异亮氨酸、甜菜碱和丙二醇的含量。结论 桂附地黄丸改善阳虚体质状态的作用机制可能与其提高丙氨酸、谷氨酰胺、α-葡萄糖、异亮氨酸、甜菜碱和丙二醇的含量,改善能量代谢紊乱,增加机体产能有关。

submitted time 2017-12-21 From cooperative journals:《南方医科大学学报》 Hits1213Downloads724 Comment 0

6. chinaXiv:201712.00604 [pdf]

60例三尖瓣下移畸形的临床分析

李 杰;刘东海;张 新;罗 鸿;臧素华;马 宁;张伟华;乔晨晖
Subjects: Medicine, Pharmacy >> Preclinical Medicine

目的探讨三尖瓣下移畸形((Ebstein畸形)的手术适应症、术后常见并发症及临床效果。方法对2005年1月一2014年12月在我院心外科行三尖瓣下移畸形(Ebstein畸形)外科治疗患者的临床资料进行回顾性分析。其中,男性31例,女性29例,年龄在1-70岁(( 0.65士15.73)岁,体质量8-91 k创3.66士15.56) kg其中隔瓣下移23例,隔瓣及后瓣下移35例,三瓣叶均下移2例,合并房缺18例,室缺6例,卵圆孔未闭4例,预激综合征6例,房扑、房颤7例,术前心功能II级32例,III级18例,IV级10例。结果60例患者均在全麻体外循环下顺利完成手术,无术中死亡,料例行三尖瓣下移畸形矫治术,16例行三尖瓣置换术,合并其它心内结构畸形患者同期行畸形矫治,2例术后出现III度房室传导阻滞,分别于术后第3,9天发生,给予水久起搏器置人,1例术后第2天因心功能衰竭逐渐引起多器官功能衰竭而死亡,其余59例患者均痊愈出院。随访6个月一10年,52例患者获得随访,随访率为88.14%。44例三尖瓣畸形矫治术患者中,40例获得随访,三尖瓣未见返流5例,少量返流20例,中度返流5例,无重度返流发生。2例置人水久起搏器患者,起搏器功能良好。结论三尖瓣下移畸形的患者目前主要还是以三尖瓣成形为主的矫治手术为主,部分畸形严重的患者可行三尖瓣置换术。

submitted time 2017-12-07 From cooperative journals:《分子影像学杂志》 Hits1108Downloads672 Comment 0

7. chinaXiv:201712.00776 [pdf]

海南汉族PLAG1 基因rs6474051 多态性与腮腺良性肿瘤的关联性

黄香(1); 邱勋定(2); 孙明磊(3); 何升腾(1)
Subjects: Medicine, Pharmacy >> Preclinical Medicine

目的 探讨海南汉族PLAG1基因rs6474051多态性与腮腺良性肿瘤的关联性。方法 以65例海南汉族腮腺良性肿瘤患者为实验组,69例正常体检者为对照,对所有入选者行PLAG1基因rs6474051多态性检测并行统计学分析。结果 CC、CT、TT三种基因型的检出例(率)在实验组中为33(50.8%)、25(38.5%)、7(10.7%),对照组中为44(63.8%)、24(34.8%)、1(1.4%),统计学分析P=0.05。等位基因C/T在两组中的检出率分别为70%/30%和80.6%/19.4%,组间差异具有统计学意义(P=0.023)。结论PLAG1基因rs6474051多态性与海南人群腮腺良性肿瘤可能存在关联,等位基因T可能是其易感基因之一。

submitted time 2017-12-07 From cooperative journals:《南方医科大学学报》 Hits553Downloads352 Comment 0

8. chinaXiv:201709.00145 [pdf]

United Approach to the Universe Model and the Local Gravitation Problem

Guang-Wen Ma; Zong-Kuan Guo
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

A united approach of the large-scale structure of a closed universe and the local spherically symmetric gravitational field is given by supposing an appropriate boundary condition. The general feature of the model obtained are the following.The universe is approximately homogeneous and isotropic on the average on large scale and is expanding at present, as described by the standard model; while locally,the small exterior region of a star started long ago to contract, as expected by the gravitational collapse theory.

submitted time 2017-09-27 Hits521Downloads251 Comment 0

9. chinaXiv:201611.00338 [pdf]

SCR脱硝副产物硫酸氢铵对锅炉尾部金属材料的腐蚀特性研究

马双忱; 邓悦; 吴文龙; 檀玉; 张立男; 柴峰; 孙盼盼; 张小霓
Subjects: Materials Science >> Materials Science (General)

通过静态失重实验研究了锅炉尾部材料碳钢和不锈钢在ABS(硫酸氢铵)和H2SO4两种溶液中的腐蚀行为,利用动电位极化曲线分析腐蚀特性。研究发现:碳钢和不锈钢在等浓度的ABS和硫酸溶液中腐蚀过程相似,说明ABS具有很强的腐蚀性。利用SEM/EDS和XPS对腐蚀产物进行了表征,通过观察碳钢和不锈钢在不同浓度ABS溶液中腐蚀产物表层的SEM形貌可知,不锈钢对ABS有更好的耐蚀性,且随着ABS溶液浓度的增大,腐蚀变剧烈。通过腐蚀产物膜的EDS和XPS分析,得到了腐蚀产物膜中的元素组成以及化合态,最终确定了腐蚀产物的种类有Fe2O3、Fe(OOH)、Fe3O4、铁的硫酸盐。由于ABS的酸性,碳钢表面首先发生酸性腐蚀,氢离子作为去极化剂,有氢气析出。随着酸度的消耗,金属表面会发生氧腐蚀,溶解氧作为去极化剂。Fe2+接着被进一步氧化为Fe3+,再发生一系列的次生反应,生成铁的氧化物以及硫酸盐等。

submitted time 2016-11-07 From cooperative journals:《中国腐蚀与防护学报》 Hits1369Downloads915 Comment 0

10. chinaXiv:201605.01420 [pdf]

A Vaccinia Virus Armed with Interleukin-10 Is a Promising Therapeutic Agent for Treatment of Murine Pancreatic Cancer

Chard, Louisa S.; Ahmed, Jahangir; El Khouri, Margueritte; Hughes, Jonathan; Lemoine, Nicholas R.; Wang, Yaohe; Maniati, Eleni; Hagemann, Thorsten; Wang, Pengju; Zhang, Zhongxian; Gao, Dongling; Wang, Jiwei; Cao, Fengyu; Lemoine, Nicholas R.; Wang, Yaohe; Wang, Shengdian; Li, Xiaozhu; Denes, Bela; Fodor, Istvan
Subjects: Biology >> Biophysics >> Oncology

Purpose: Vaccinia virus has strong potential as a novel therapeutic agent for treatment of pancreatic cancer. We investigated whether arming vaccinia virus with interleukin-10 (IL10) could enhance the antitumor efficacy with the view that IL10 might dampen the host immunity to the virus, increasing viral persistence, thus maximizing the oncolytic effect and antitumor immunity associated with vaccinia virus. Experimental Design: The antitumor efficacy of IL10-armed vaccinia virus (VVL Delta TK-IL10) and control VV Delta TK was assessed in pancreatic cancer cell lines, mice bearing subcutaneous pancreatic cancer tumors and a pancreatic cancer transgenic mouse model. Viral persistence within the tumors was examined and immune depletion experiments as well as immunophenotyping of splenocytes were carried out to dissect the functional mechanisms associated with the viral efficacy. Results: Compared with unarmed VVL Delta TK, VVL Delta TK-IL10 had a similar level of cytotoxicity and replication in vitro in murine pancreatic cancer cell lines, but rendered a superior antitumor efficacy in the subcutaneous pancreatic cancer model and a K-ras-p53 mutant-transgenic pancreatic cancer model after systemic delivery, with induction of long-term antitumor immunity. The antitumor efficacy of VVL Delta TK-IL10 was dependent on CD4(+) and CD8(+), but not NK cells. Clearance of VVL Delta TK-IL10 was reduced at early time points compared with the control virus. Treatment with VVL Delta TK-IL10 resulted in a reduction in virus-specific, but not tumor-specific CD8+ cells compared with VVL Delta TK. Conclusions: These results suggest that VVL Delta TK-IL10 has strong potential as an antitumor therapeutic for pancreatic cancer. (C) 2014 AACR.

submitted time 2016-05-12 Hits3951Downloads1442 Comment 0

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