分类: 动力与电气工程 >> 电气工程 提交时间: 2019-03-05 合作期刊: 《电气工程学报》
摘要: 当脉冲电流通过实验先进超导托卡马克 (EAST) 快控电源中空心电 抗器时会产生磁场,导致输出柜发热。为了解决热问题,在空心电抗器周围 安装一层或两层屏蔽体。电流幅值最大为 1 500A 时,求解空心电抗器周围磁 场分布以及输出柜的涡流损耗。将涡流损耗作为主要的热源,根据电磁学和 热力学理论建立电抗器的三维磁热耦合有限元模型。本文对空心电抗器的温 度场进行分析和讨论。结果表明,在屏蔽条件下空心电抗器的磁场和输出柜 的温度都会降低。
分类: 生物学 >> 生物物理学 提交时间: 2016-05-12
摘要: Non-homologous end joining (NHEJ) is a major pathway to repair DNA double-strand breaks (DSBs), which can display different types of broken ends. However, it is unclear how NHEJ factors organize to repair diverse types of DNA breaks. Here, through systematic analysis of the human NHEJ factor interactome, we identify PAXX as a direct interactor of Ku. The crystal structure of PAXX is similar to those of XRCC4 and XLF. Importantly, PAXX-deficient cells are sensitive to DSB-causing agents. Moreover, epistasis analysis demonstrates that PAXX functions together with XLF in response to ionizing radiation-induced complex DSBs, whereas they function redundantly in response to Topo2 inhibitor-induced simple DSBs. Consistently, PAXX and XLF coordinately promote the ligation of complex but not simple DNA ends in vitro. Altogether, our data identify PAXX as a new NHEJ factor and provide insight regarding the organization of NHEJ factors responding to diverse types of DSB ends.