分类： 动力与电气工程 >> 工程热物理学 提交时间： 2017-06-22 合作期刊: 《热科学学报》
摘要： Effects of the uneven circumferential blade space on static characteristics and aerodynamic noise of a small axial flow fan are studied in this work. The blade angle modulation is adopted to design a series of unequally spaced fans, which have different maximum of modulation angular displacement. The steady flow is simulated by the calculations of Navier-Stokes equations coupled with RNG k-epsilon turbulence model, while the unsteady flow is computed with large eddy simulation. According to theoretical analysis, a fan with a maximum of modulation angular displacement of 6 is regarded as the optimal unequally spaced fan. The experiment of static characteristic is carried out in a standard wind tunnel and the aerodynamic noise of both fans is tested in a semi-anechoic room. Then, performances of the optimal unequally spaced fan are compared with those of the prototype fan. The results show that there is reasonable agreement between the simulation results and the experimental data. It is found that the discrete noise of the optimal unequally spaced fan is lower than that of the prototype fan at the near field monitoring point. This can be explained that the total pressure fluctuation of the optimal unequally spaced fan is much more regular than that of the prototype fan.
分类： 生物学 >> 生物医药 提交时间： 2017-05-10
Liang L. Zhou
Yun Zhao
Ashley Ringrose
Donna DeGeer
Erin Kennah
Ann E.-J. Lin
Guoqing Sheng
Xiao-Jiang Li
Ali Turhan
Xiaoyan Jiang
摘要： Chronic myeloid leukemia (CML) represents the first human malignancy successfully treated with a tyrosine kinase inhibitor (TKI; imatinib). However, early relapses and the emergence of imatinib-resistant disease are problematic. Evidence suggests that imatinib and other inhibitors may not effectively eradicate leukemic stem/progenitor cells, and that combination therapy directed to complimentary targets may improve treatment. Abelson helper integration site 1 (Ahi-1)/AHI-1 is a novel oncogene that is highly de-regulated in CML stem/progenitor cells where levels of BCR-ABL transcripts are also elevated. Here, we demonstrate that overexpression of Ahi-1/AHI-1 in murine and human hematopoietic cells confer growth advantages in vitro and induce leukemia in vivo, enhancing effects of BCR-ABL. Conversely, RNAi-mediated suppression of AHI-1 in BCR-ABL-transduced lin(-)CD34(+) human cord blood cells and primary CML stem/progenitor cells reduces their growth autonomy in vitro. Interestingly, coexpression of Ahi-1 in BCR-ABL-inducible cells reverses growth deficiencies exhibited by BCR-ABL down-regulation and is associated with sustained phosphorylation of BCR-ABL and enhanced activation of JAK2-STAT5. Moreover, we identified an AHI-1-BCR-ABL-JAK2 interaction complex and found that modulation of AHI-1 expression regulates phosphorylation of BCR-ABL and JAK2-STAT5 in CML cells. Importantly, this complex mediates TKI response/resistance of CML stem/progenitor cells. These studies implicate AHI-1 as a potential therapeutic target downstream of BCR-ABL in CML.
点击量
点击量
下载量
评论
待评议
