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1. chinaXiv:202105.00010 [pdf]

Characteristics and hazards of different snow avalanche types in a continental snow climate region in the Central Tianshan Mountains

HAO Jiansheng; Richard MIND'JE; LIU Yang; HUANG Farong; ZHOU Hao; LI Lanhai
Subjects: Geosciences >> Geography

Snow avalanches are a common natural hazard in many countries with seasonally snow-covered mountains. The avalanche hazard varies with snow avalanche type in different snow climate regions and at different times. The ability to understand the characteristics of avalanche activity and hazards of different snow avalanche types is a prerequisite for improving avalanche disaster management in the mid-altitude region of the Central Tianshan Mountains. In this study, we collected data related to avalanche, snowpack, and meteorology during four snow seasons (from 2015 to 2019), and analysed the characteristics and hazards of different types of avalanches. The snow climate of the mid-altitude region of the Central Tianshan Mountains was examined using a snow climate classification scheme, and the results showed that the mountain range has a continental snow climate. To quantify the hazards of different types of avalanches and describe their situation over time in the continental snow climate region, this study used the avalanche hazard degree to assess the hazards of four types of avalanches, i.e., full-depth dry snow avalanches, full-depth wet snow avalanches, surface-layer dry snow avalanches, and surface-layer wet snow avalanches. The results indicated that surface-layer dry snow avalanches were characterized by large sizes and high release frequencies, which made them having the highest avalanche hazard degree in the Central Tianshan Mountains with a continental snow climate. The overall avalanche hazard showed a single peak pattern over time during the snow season, and the greatest hazard occurred in the second half of February when the snowpack was deep and the temperature increased. This study can help the disaster and emergency management departments rationally arrange avalanche relief resources and develop avalanche prevention strategies.

submitted time 2021-04-30 Cooperative journals:《Journal of Arid Land》 Hits2915Downloads666 Comment 0

2. chinaXiv:201705.00578 [pdf]

Hexamethylene diisocyanate as an electrolyte additive for high-energy density lithium ion batteries

Liu, Y [Liu, Yang][ 1 ]; Qin, YP [Qin, Yinping][ 1 ]; Peng, Z [Peng, Zhe][ 1 ]; Zhou, JJ [Zhou, Jingjing][ 1 ]; Wan, CJ [Wan, Changjin][ 1 ]; Wang, DY [Wang, Deyu][ 1 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

Hexamethylene diisocyanate can chemically react with the onium ion produced by the oxidation of propylene carbonate and in situ generate a novel interfacial layer that is stable at high potential. With an appropriate thickness of this film, LiNi1/3Co1/3Mn1/3O2 presents significantly improved rate and cycle performances when tested between 2.5 and 4.6 V (vs. Li/Li+).

submitted time 2017-05-02 Hits1202Downloads694 Comment 0

3. chinaXiv:201705.00575 [pdf]

Correlation of oxygen non-stoichiometry to the instabilities and electrochemical performance of LiNi0.8Co0.1Mn0.1O2 utilized in lithium ion battery

Bi, YJ [Bi, Yujing][ 1 ]; Yang, WC [Yang, Wenchao][ 1 ]; Du, R [Du, Rui][ 1 ]; Zhou, JJ [Zhou, Jingjing][ 1 ]; Liu, M [Liu, Meng][ 1 ]; Liu, Y [Liu, Yang][ 1 ]; Wang, DY [Wang, Deyu][ 1 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

In this work, we investigate the influence of oxygen non-stoichiometry on the characteristics of LiNi0.8Co0.1Mn0.1O2 cathode material. Among the investigated samples, the level of Ni/Li disorder in the bulk and the thickness of auto-generated layer on the surface share the same trend as the amount of oxygen loss in LiNi0.8Co0.1Mn0.1O2 materials. It indicates that the aforementioned key structural in- stabilities should be tightly related to the oxygen defects and the induced structural relaxation. As a consequence of structural entirety, the sample with the least defects presents the highest discharge capacity (192.9 mAhg 1 at 0.1C), the best rate capability (160.1 mAhg 1 at 5C), and the most stable cyclibility (89.9% at 200th). Our results demonstrate that oxygen deficiency plays a key role to determine the electrochemical performance of high-nickel cathode materials.

submitted time 2017-05-02 Hits1273Downloads828 Comment 0

4. chinaXiv:201705.00454 [pdf]

Volumetric variation confinement: surface protective structure for high cyclic stability of lithium metal electrodes

Peng, Z [Peng, Zhe][ 1 ]; Wang, SW [Wang, Shuwei][ 1 ]; Zhou, JJ [Zhou, Jingjing][ 1 ]; Jin, Y [Jin, Yan][ 1 ]; Liu, Y [Liu, Yang][ 1 ]; Qin, YP [Qin, Yinping][ 1 ]; Shen, C [Shen, Cai][ 1 ]; Han, WQ [Han, Weiqiang][ 1 ]; Wang, DY [Wang, Deyu][ 1 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

A surface protective structure to efficiently improve the cyclic stability and lifetime of the lithium metal electrode is investigated. By volu- metrically confining plated lithium metal in the inter-space of a ceramic porous layer and isolating the confined lithium via a rein- forced skin-layer from attack by electrolyte solvents, the coulombic efficiency of the protected lithium metal electrode reaches very high values of $97–99%.

submitted time 2017-05-02 Hits1028Downloads651 Comment 0

5. chinaXiv:201705.00341 [pdf]

Proton-Conducting Graphene Oxide-Coupled Neuron Transistors for Brain-Inspired Cognitive Systems

Wan, CJ [Wan, Chang Jin][ 1,2,3 ]; Zhu, LQ [Zhu, Li Qiang][ 3 ]; Liu, YH [Liu, Yang Hui][ 3 ]; Feng, P [Feng, Ping][ 1,2 ]; Liu, ZP [Liu, Zhao Ping][ 3 ]; Cao, HL [Cao, Hai Liang][ 3 ]; Xiao, P [Xiao, Peng][ 3 ]; Shi, Y [Shi, Yi][ 1,2 ]; Wan, Q [Wan, Qing][ 1,2,3 ]

Proton-conducting graphene oxide electrolyte films with very high electric-double-layer capacitance are used as the gate dielectrics for oxide-based neuron transistor fabrication. Paired-pulse facilitation, dendritic integration, and orientation tuning ar

submitted time 2017-05-02 Hits1355Downloads787 Comment 0

6. chinaXiv:201605.01318 [pdf]

A novel phosphodiesterase-5 Inhibitor: Yonkenafil modulates neurogenesis, gliosis to improve cognitive function and ameliorates amyloid burden in an APP/PS1 transgenic mice model

Zhu, Lei; Yang, Jing-Yu; Dong, Ying-Xu; Liu, Yang; Miao, Feng-Rong; Xue, Hong; Wu, Chun-Fu; Xue, Hong; Xue, Xue; Wang, Yong-Feng
Subjects: Biology >> Biophysics >> Cell Biology

In Alzheimer's disease (AD), activated microglia invade and surround beta-amyloid plaques, possibly contributing to the aggregation of amyloid beta (A beta), which affect the survival of neurons and lead to memory loss. Phosphodiesterase-5 (PDE-5) inhibitors have recently been shown a potential therapeutic effect on AD. In this study, the effects of yonkenafil (yonk), a novel PDE-5 inhibitor, on cognitive behaviors as well as the pathological features in transgenic AD mice were investigated. Seven-month-old APP/PSI transgenic mice were treated with yonk (2, 6, or 18 mg/kg, intraperitoneal injection (i.p.)) or sildenafil (slid) (6 mg/kg, i.p.) daily for 3 months and then behavioral tests were performed. The results demonstrated that yonk improved nesting-building ability, ameliorated working memory deficits in the Y-maze tasks, and significantly improved learning and memory function in the Morris water maze (MWM) tasks. In addition, yonk reduced the area of A beta plaques, and inhibited over-activation of microglia and astrocytes. Furthermore, yonk increased neurogenesis in the dentate granule brain region of APP/PSI mice, indicated by increased BrdU(+)/NeuN(+) and BrdU(+)/DCX+ cells compared to vehicle-treated transgenic mice. These results suggest that yonk could rescue cognitive deficits by ameliorated amyloid burden through regulating APP processing, inhibited the over-activation of microglia and astrocytes as well as restored neurogenesis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

submitted time 2016-05-11 Hits1851Downloads1266 Comment 0

7. chinaXiv:201605.01271 [pdf]

Nanozyme-strip for rapid local diagnosis of Ebola

Duan, Demin; Fan, Kelong; Zhang, Dexi; Zhang, Jianlin; Yan, Xiyun; Tan, Shuguang; Gao, George Fu; Liang, Mifang; Liu, Yang; Zhang, Panhe; Liu, Wei; Qiu, Xiangguo; Kobinger, Gary P.; Gao, George Fu
Subjects: Biology >> Biophysics

Ebola continues to rage in West Africa. In the absence of an approved vaccine or treatment, the priority in controlling this epidemic is to promptly identify and isolate infected individuals. To this end, a rapid, highly sensitive, and easy-to-use test for Ebola diagnosis is urgently needed. Here, by using Fe3O4 magnetic nanoparticle (MNP) as a nanozyme probe, we developed a MNP-based immunochromatographic strip (Nanozyme-strip), which detects the glycoprotein of Ebola virus (EBOV) as low as 1 ng/mL, which is 100-fold more sensitive than the standard strip method. The sensitivity of the Nanozyme-strip for EBOV detection and diagnostic accuracy for New Bunyavirus clinical samples is comparable with ELISA, but is much faster (within 30 min) and simpler (without need of specialist facilities). The results demonstrate that the Nanozyme-strip test can rapidly and sensitively detect EBOV, providing a valuable simple screening tool for diagnosis of infection in Ebola-stricken areas. (C) 2015 Elsevier B.V. All rights reserved.

submitted time 2016-05-11 Hits1989Downloads1136 Comment 0

8. chinaXiv:201605.01242 [pdf]

Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation

Wang, Lizhong; Liu, Runhua; Ye, Peiying; Wong, Chunshu; Chen, Guo-Yun; Sakabe, Kaoru; Jube, Sandro; Zheng, Pan; Liu, Yang; Ye, Peiying; Wong, Chunshu; Chen, Guo-Yun; Sakabe, Kaoru; Jube, Sandro; Zheng, Pan; Liu, Yang; Ye, Peiying; Zhou, Penghui; Zheng, Xincheng; Wu, Wei
Subjects: Biology >> Biophysics

CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently mutated tumour-suppressor gene that functions in a context-dependent manner. Here we show that both targeted mutation and short hairpin RNA (shRNA) silencing of CD24 retard the growth, progression and metastasis of prostate cancer. CD24 competitively inhibits ARF binding to NPM, resulting in decreased ARF, increase MDM2 and decrease levels of p53 and the p53 target p21/CDKN1A. CD24 silencing prevents functional inactivation of p53 by both somatic mutation and viral oncogenes, including the SV40 large T antigen and human papilloma virus 16 E6-antigen. In support of the functional interaction between CD24 and p53, in silico analyses reveal that TP53 mutates at a higher rate among glioma and prostate cancer samples with higher CD24 mRNA levels. These data provide a general mechanism for functional inactivation of ARF and reveal an important cellular context for genetic and viral inactivation of TP53.

submitted time 2016-05-11 Hits1979Downloads1102 Comment 0

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