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1. chinaXiv:202105.00003 [pdf]

Sepsis prediction via the clinical data integration system in the ICU

Chen, Qiyu; Li, Ranran; Lin, Zhizhe; Lai, Zhiming; Xue, Peijiao; Jiang, Jingfeng; Lu, Wenlian; Li, Lei; Tang, Yaoqing
Subjects: Medicine, Pharmacy >> Clinical Medicine

Sepsis is an essential issue in critical care medicine, and early detection and intervention are key for survival. We established the sepsis early warning system based on a data integration platform that can be implemented in ICU. The sepsis early warning module can detect the onset of sepsis 5 hours proceeding, and the data integration platform integrates, standardizes, and stores information from different medical devices, making the inference of the early warning module possible. Our best early warning model got an AUC of 0.9833 in the task of detect sepsis in 4 hours proceeding on the open-source database. Our data integration platform has already been operational in a hospital for months.

submitted time 2021-05-07 Hits10509Downloads500 Comment 0

2. chinaXiv:201711.00143 [pdf]

Transitional Area of Ce4+ to Ce3+ in SmxCayCe1-x-yO2-δ with Various Doping and Oxygen Vacancy Concentrations: A GGA + U Study

WU Tong-Wei; JIA Gui-Xiao; WANG Xiao-Xia; LI Lei; AN Sheng-Li
Subjects: Chemistry >> Physical Chemistry

In this work, we perform DFT + U periodic calculations to study geometrical and electronic structures and oxygen vacancy formation energies of SmxCayCe1-x-yO2-δ systems (x = 0.0312, 0.0625, 0.125 and 0.250; y = 0.0312, 0.0625, 0.125 and 0.250; δ = 0.0312, 0.0625, 0.125, 0.250 and 0.50) with different oxygen vacancy and doping concentrations. The calculated results show that the V1-Sm3+-V2 structures where there is a position relationship of the face diagonal between V1 and V2 both nearest to Sm3+ have the lowest energy configurations. The study on electronic structures of the SmxCayCe1-x-yO2-δ systems finds that excess electrons arise from oxygen vacancies and are localized on f-level traps of their neighbor Ce, and Ca2+ and Sm3+ co-doping effectively restrains the reduction of Ce4+. In order to avoid the existence of Ce3+, x and y must be both larger than 0.0625 as δ = 0.125 or δ must be smaller than 0.125 as x = y = 0.0625. The Ce3+/Ce4+ change ratio k has an obvious monotonous increase with increasing the vacancy oxygen concentration. The introduction of Sm3+ decreases k. In addition, the doped Sm3+ can restrain the reduction of Ce4+ when the V1-Sm3+-V2 structure with a face diagonal position relationship in lower reduced atmosphere exists. It need be pointed out that the Sm0.25Ce0.75O1.5 system should be thought of as a Sm-doped Ce2O3 one.

submitted time 2017-11-05 From cooperative journals:《结构化学》 Hits2141Downloads1580 Comment 0

3. chinaXiv:201605.01322 [pdf]

Studies on Inhibition of Proliferation of Enterovirus-71 by Compound YZ-LY-0

Yang, Qingzhan; Shaw, Neil; Rao, Zihe; Lou, Zhiyong; Jie, Qing; Shaw, Neil; Rao, Zihe; Yin, Zheng; Yin, Zheng; Yin, Zheng; Li, Lei; Rao, Zihe; Lou, Zhiyong; Li, Lei; Rao, Zihe; Lou, Zhiyong; Li, Lei; Rao, Zihe; Lou, Zhiyong
Subjects: Biology >> Biophysics >> Biochemistry & Molecular Biology

In recent years, hand-foot-and-mouth disease (HFMD), which is caused by Enteroviruses, has emerged as a serious illness. It affects mainly children under the age of five and results in high fatality rates. Enterovirus 71 (EV71) is the main causative agent of HFMD in China and currently there are no effective anti-viral drugs available to treat HFMD. In the present study, we screened compounds for inhibition of proliferation of EV71. Compound YZ-LY-0 stalled the life cycle of EV71. The inhibitor exhibited EC50 value of 0.29 mu m against SK-EV006 strain of EV71. Notably, YZ-LY-0 had low cytotoxicity (CC50 > 100 mu M) and a high selectivity index (over 300) in Vero and RD cells. YZ-LY-0 in combination with an EV71 RdRp inhibitor or an entry inhibitor showed an antagonistic effect at very low concentrations. However, at higher concentrations the inhibitors exhibited a synergistic effect in inhibiting viral replication. Preliminary results on investigation of the mechanism of inhibition indicate that YZ-LY-0 does not block the entry of the virus in the host cell, but instead inhibits an early stage of EV71 replication. Our studies provide a potential clinical therapeutic option against EV71 infections and suggest that a combined application of YZ-LY-0 with other inhibitors could be more effective in the treatment of HFMD.

submitted time 2016-05-11 Hits1815Downloads1059 Comment 0

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