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1. chinaXiv:202104.00083 [pdf]

Method Based on Support Vector Machine and Sequential Backward Selection for Seismic Liquefaction Potential Evaluation

Jianping LI; Runrun DONG; Jiansheng WANG; Ling CHEN
Subjects: Civil Engineering and Building Construction >> Civil Construction Structures

[Object] In the paper, the support vector machine(SVM) is utilized to evaluate the earthquake-induced site liquefaction potential, and an optimization algorithm based on cross validation and sequential backward selection(SBS) is proposed to improve the generalization ability of the classifier for seismic liquefaction potential evaluation(SLPE). [Methods] Usually, the accuracy of SLPE using the SVM varies greatly when the training dataset and test dataset change, so the classifier is not reliable enough in practice. Because cross validation is more convincing for evaluating the classifier performance in machine learning , the algorithm in the paper tries to reduce the maximum error of cross validation through adopting SBS to determine the input variables of the SVM. The performance of the classifier is assessed by the area under the curve (AUC) on the basis of confusion matrix. [Results] As shown by data validation, the algorithm can reduce the maximum error of cross validation and the variation of accuracy in SLPE while maintaining good performance of the classifier. [Conclusions] In conclusion, a method that can improve the reliability of SVMs for classification in SLPE is put forward in the paper.

submitted time 2021-04-19 Hits714Downloads454 Comment 0

2. chinaXiv:202001.00046 [pdf]

A general self-consistent framework for studying cumulative displacement damage in nanostructured metals based on parameter passing and structural feedback between atomic and coarse-grained techniques

Xiangyan Li; Yange Zhang; Yichun Xu; Xuebang Wu; Xianping Wang; B.C. Pan; C.S. Liu; Q.F. Fang; Jun-Ling Chen; G.-N. Luo; Zhiguang Wang; X. Liu
Subjects: Materials Science >> Materials Science (General)

Nano-crystalline metals (NCs) exhibit radiation-tolerance due to the sink of grain boundaries (GBs) for radiation-induced defects such as self-interstitial atoms (SIAs) and vacancies (Vs). However, the relevant mechanisms for the radiation damage accumulation and GB structural relaxation under high radiation field in NCs are still not well understood due to the lack of self-consistent across-scale techniques for simulating radiation-induced microstructures evolution. In this article, by combining coarse-grained and atomistic simulations, we proposed a coupling method to investigate the evolution of the microstructure and SIA/V-GB interaction under cumulative irradiation in NC iron. The SIA overloaded effect was revealed in iron GBs at a high radiation dose rate and/or low temperature. Two types of GB structural response were observed to cumulative irradiation. With the SIA accumulated at the GB, the new GB phase formed and then a critical concentration of the SIA at the GB transited to the small quantity of the V during the GB structural recovery, accompanied by the local GB motion. Consequently, the GB’s role for Vs nearby alternated between the trapping and annihilation center with radiation dose. Alternatively, GB developed to a disordered structure after trapping abundant SIAs. The GB response pattern to cumulative irradiation that is related to the SIA formation energy at the GB or the GB thermal stability is well manifested in the cumulative distribution function of the defects formation energy and its energy level density. The present work reveals the dynamic healing picture for radiation damage near the GB under cumulative irradiation.

submitted time 2020-01-07 Hits24145Downloads1496 Comment 0

3. chinaXiv:201711.02427 [pdf]

Discovery of multiple lead compounds as M2 inhibitors through the screening of a focused library of scaffold-hops

Wenhui Hu; Shaogao Zeng; Chufang Li; Zhiyuan Li; Ling Chen
Subjects: Biology >> Ecology

It is urgent to discover new anti-influenza drugs considering the threat of so called swine flu and Spanish flu. Though Adamantane derivatives are the only M2 inhibitors as anti-influenza virus A drugs, they are limited to use in the US due to drug resistant. Herein we reported that multiple lead compounds as M2 inhibitors were rapidly generated through the screening of focused library designed with scaffold-hopping strategy based on Amantadine.

submitted time 2017-11-17 Hits1630Downloads897 Comment 0

4. chinaXiv:201711.02428 [pdf]

Discovery of Multiple Lead Compounds as M2 Inhibitors through the Focused Screening of a Small Primary Amine Library

Wenhui Hu; Shaogao Zeng; Chufang Li; Yanling Jie; Zhiyuan L; Ling Chen
Subjects: Biology >> Ecology

The discovery of new anti-influenza drugs is urgent, particularly considering the recent threat of swine flu. Although amantadine derivatives are the only M2 drugs for influenza virus A, their use is limited in the US due to drug resistance. Here we report the discovery of multiple M2 inhibitor lead compounds that were rapidly generated through focused screening of a small primary amine library which was designed using a scaffold-hopping strategy based on amantadine.

submitted time 2017-11-17 Hits1679Downloads946 Comment 0

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