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1. chinaXiv:201711.02416 [pdf]

Toll-like?receptor?2?costimulation?potentiates?the?antitumor?efficacy?of?CAR?T?Cells.

Lai, Y; Weng, J; Wei, X; Qin, L; Lai, P; Zhao, R; Jiang, Z; Li, B; Lin, S; Wang, S; Wu, Q; Tang, Z; Liu, P; Pei, D; Yao, Y; Du, X; Li, P
Subjects: Biology >> Ecology

Chimeric antigen receptor (CAR) T-cell immunotherapies have shown unprecedented success in treating leukemia but limited clinical efficacy in solid tumors. Here, we generated 1928zT2 and m28zT2, targeting CD19 and mesothelin, respectively, by introducing the Toll/interleukin-1 receptor domain of Toll-like receptor 2 (TLR2) to 1928z and m28z. T cells expressing 1928zT2 or m28zT2 showed improved expansion, persistency and effector function against CD19+ leukemia or mesothelin+ solid tumors respectively in vitro and in vivo. In a patient with relapsed B-cell acute lymphoblastic leukemia, a single dose of 5 * 104/kg 1928zT2 T cells resulted in robust expansion and leukemia eradication and led to complete remission. Hence, our results demonstrate that TLR2 signaling can contribute to the efficacy of CAR T cells. Further clinical trials are warranted to establish the safety and efficacy of this approach.Leukemia advance online publication, 25 August 2017; doi:10.1038/leu.2017.249.

submitted time 2017-11-17 Hits1570Downloads961 Comment 0

2. chinaXiv:201705.00533 [pdf]

Silicon Oxycarbide/Carbon Nanohybrids with Tiny Silicon Oxycarbide Particles Embedded in Free Carbon Matrix Based on Photoactive Dental Methacrylates

Wang, MM [Wang, Meimei][ 1,2 ]; Xia, YG [Xia, Yonggao][ 1 ]; Wang, XY [Wang, Xiaoyan][ 1,3 ]; Xiao, Y [Xiao, Ying][ 1 ]; Liu, R [Liu, Rui][ 4,5 ]; Wu, Q [Wu, Qiang][ 6 ]; Qiu, B [Qiu, Bao][ 1 ]; Metwalli, E [Metwalli, Ezzeldin][ 7 ]; Xia, SL [Xia, Senlin][ 7 ]; Yao, Y [Yao, Yuan][ 7 ]; Chen, GX [Chen, Guoxin][ 1 ]; Liu, Y [Liu, Yan][ 1 ]; Liu, ZP [Liu, Zhaoping][ 1 ]; Meng, JQ [Meng, Jian-Qjang][ 3 ]; Yang, ZH [Yang, Zhaohui][ 6 ]; Sun, LD [Sun, Ling-Dong][ 4,5 ]; Yan, CH [Yan, Chun-Hua][ 4,5 ]; Muller-Buschbaum, P [Mueller-Buschbaum, Peter][ 7 ]; Pan, J [Pan, Jing][ 2 ]; Cheng, YJ [Cheng, Ya-Jun][ 1 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

A new facile scalable method has been developed to synthesize silicon oxycarbide (SiOC)/carbon nanohybrids using difunctional dental methacrylate monomers as solvent and carbon source and the silane coupling agent as the precursor for SiOC. The content (from 100% to 40% by mass) and structure (ratio of disor- dered carbon over ordered carbon) of the free carbon matrix have been systematically tuned by varying the mass ratio of methacryloxy- propyltrimethoxysilane (MPTMS) over the total mass of the resin monomers from 0.0 to 6.0. Compared to the bare carbon anode, the introduction of MPTMS significantly improves the electrochemical performance as a lithium-ion battery anode. The initial and cycled discharge/charge capacities of the SiOC/C nanohybrid anodes reach maximum with the MPTMS ratio of 0.50, which displays very good rate performance as well. Detailed structures and electrochemical performance as lithium-ion battery anodes have been systematically investigated. The structure?property correlation and corresponding mechanism have been discussed.

submitted time 2017-05-02 Hits1008Downloads624 Comment 0

3. chinaXiv:201705.00046 [pdf]

Evaluation of PHBHHx and PHBV/PLA fibers used as medical sutures

He, Y [He, Yu][ 1 ]; Hu, ZW [Hu, Zhiwei][ 2 ]; Ren, MD [Ren, Mengda][ 1 ]; Ding, CK [Ding, Changkun][ 3 ]; Chen, P [Chen, Peng][ 4 ]; Gu, Q [Gu, Qun][ 4 ]; Wu, Q [Wu, Qiong][ 1,5,6 ]
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

Two types of fibers were prepared by using bio- based materials: a mono-filament made from poly(3- hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and a multi-filament made from poly(3-hydroxybutyrate-co-3- hydroxyvalerate) (PHBV) and polylactic acid (PLA) blend. The two fibers were evaluated for mechanical properties, biocompatibility and degradability for the potential appli- cation as medical sutures. The PHBHHx fiber showed remarkable biocompatibility by H.E. Stainning, with very little impact to the surrounding tissues. The degradation of the fiber was observed by SEM after implantation for 36 weeks, and the major degradation product was detected after 96 weeks. Consistently, the PHBHHx fiber main- tained more than half of the mechanical properties after 96 weeks. The other fiber was prepared by twisting PHBV/PLA blend strands to a bunch, and showed high biocom- patibility and relatively high degradability. The bunched structure loosed after 36 weeks of implantation. These low- cost and easily prepared fibers have great potential in medical applications, since they could avoid the formation of fibrous capsule, reduce the size of scar, and degrade into non-toxic and even beneficial products.

submitted time 2017-05-02 Hits1450Downloads836 Comment 0

4. chinaXiv:201704.00068 [pdf]

Chlorobenzene vapor assistant annealing method for fabricating high quality perovskite films

He, Y; Hu, ZW; Ren, MD; Ding, CK; Chen, P; Gu, Q; Wu, Q

In this study, chlorobenzene (CB) vapor assistant annealing (VAA) method is employed to make high quality perovskite films and produce high efficiency CH3NH3PbI3-xClx perovskite solar cells. The perovskite films made by this method present several advanta

submitted time 2017-04-06 Hits1011Downloads647 Comment 0

5. chinaXiv:201704.00067 [pdf]

Evaluation of PHBHHx and PHBV/PLA fibers used as medical sutures

He, Y; Hu, ZW; Ren, MD; Ding, CK; Chen, P; Gu, Q; Wu, Q
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

Two types of fibers were prepared by using bio-based materials: a mono-filament made from poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and a multi-filament made from poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and polylactic acid (PLA) b

submitted time 2017-04-06 Hits1116Downloads667 Comment 0

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