摘要：In this study, we theoretically investigate the feasibility of using laser-wakefield accelerated (LWFA) electrons for the photonuclear measurement of nuclear isomers according to the characteristics of the electrons obtained from LWFA experiments conducted at the Compact Laser Plasma Accelerator (CLAPA) laboratory. The experiments at the CLAPA show that a stable electron beam with an energy of 78–135 MeV and a charge of 300-600 pC can be obtained. The bremsstrahlung spectra were simulated using Geant4, which suggests that a bremsstrahlung source with a peak intensity of 1019 photons/s can be generated. Theoretical calculations of isomer production cross-sections from the photonuclear reactions on six target nuclei, 197Au, 180Hf, 159Tb, 115In, 103Rh, and 90Zr were performed and compared with the available experimental data in EXFOR, which suggest that further experiments are required for a series of photonuclear reaction channels. Flux-averaged cross-sections and isomer ratios (IR) resulting from such bremsstrahlung sources are theoretically deduced. The results suggest that IR measurements can be used to constrain nuclear components, such as γ strength function and optical model potential. In addition, the detection of the decay characteristics was evaluated with Geant4 simulations. The use of the LWFA electron beam and its bremsstrahlung for photonuclear studies involving nuclear isomers is anticipated.