分类: 核科学技术 >> 辐射物理与技术 提交时间: 2024-05-30
摘要: DD4hep serves as a generic detector de Conversely, Filmbox~(FBX) stands out as a widely used 3D modeling file format within the 3D software industry.In this paper, we introduce a novel method that can automatically convert complex HEP detector geometries from DD4hep de The feasibility of this method was demonstrated by its application to the DD4hep de The automatic DD4hep--FBX detector conversion interface provides convenience for further development of applications, such as detector design, simulation, visualization, data monitoring, and outreach, in HEP experiments.
分类: 生物学 >> 生物物理学 提交时间: 2016-05-12
摘要: The participation of large-conductance Ca2+ activated K+ channels (BKs) in chloroquine (chloro)-induced relaxation of precontracted airway smooth muscle (ASM) is currently undefined. In this study we found that iberiotoxin (IbTx, a selective inhibitor of BKs) and chloro both completely blocked spontaneous transient outward currents (STOCs) in single mouse tracheal smooth muscle cells, which suggests that chloro might block BKs. We further found that chloro inhibited Ca2+ sparks and caffeine-induced global Ca2+ increases. Moreover, chloro can directly block single BK currents completely from the intracellular side and partially from the extracellular side. All these data indicate that the chloro-induced inhibition of STOCs is due to the blockade of chloro on both BKs and ryanodine receptors (RyRs). We also found that low concentrations of chloro resulted in additional contractions in tracheal rings that were precontracted by acetylcholine (ACH). Increases in chloro concentration reversed the contractile actions to relaxations. In the presence of IbTx or paxilline (pax), BK blockers, chloro-induced contractions were inhibited, although the high concentrations of chloro-induced relaxations were not affected. Taken together, our results indicate that chloro blocks BKs and RyRs, resulting in abolishment of STOCs and occurrence of contraction, the latter will counteract the relaxations induced by high concentrations of chloro.