An efficient method for the synthesis of disubstituted thioureas via the reaction of N,N0-di-Boc-substituted thiourea with alkyl and aryl amines under mild conditions

Subjects: Biology >> Biomedical Laboratory Science submitted time 2017-05-10

Biaolin Yin Zhaogui Liu Mingjun Yi Jiancun Zhang

Abstract：An efficient method for the synthesis of disubstituted thioureas via the reaction of N,N0-di-Boc-substituted thiourea 5 with alkyl and aryl amines under mild conditions has been developed. In the presence of NaH as a base, trifluoroacetic anhydride (TFAA) reacted with 5 providing intermediate 6, which then reacted with amines giving thioureas 7 in excellent yields. This reaction conditions tolerated other functional groups such as amide, ester, enol ether and hydroxyl groups.

Peer Review Status:Awaiting Review

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