分类： 核科学技术 >> 裂变堆工程技术 提交时间： 2021-12-31
摘要： Nuclear data are the cornerstones of reactor physics and shielding calculations. Recently, China released CENDL-3.2 in 2020, and the United States released ENDF/B-VIII.0 in 2018. Therefore, it is necessary to comprehensively evaluate the criticality computing performance of these newly released evaluated nuclear libraries. In this study, we used the NJOY2016 code to generate ACE format libraries based on the latest neutron data libraries (including CENDL-3.2, JEFF3.3, ENDF/B-VIII.0, and JENDL4.0). The MCNP code was used to conduct a detailed analysis of fission nuclides, including 235U, 233U, and 239Pu, in different evaluated nuclear data libraries based on 100 benchmarks. The criticality calculation performance of each library was evaluated using three statistical parameters: , , and . Analysis of the parameter showed that CENDL-3.1 and JENDL-4.0 both had >10 benchmarks that exceeded 3σ, whereas CENDL-3.2, ENDFB-VIII.0, and JEFF-3.3 had, 7, 5, and 4 benchmarks, respectively, exceeding 3σ. The ENDF/B-VII.1 library performed best, with only two benchmarks exceeding 3σ. Compared with CENDL-3.1, CENDL-3.2 offers an improvement in criticality calculations. Compared with the JEFF-3.3 and ENDF/B-VIII.0 libraries, CENDL3.2 performs better in the calculation of the 233U assemblies, but it performs poorly in the pusl11 series case calculation of the 239Pu assemblies, and thus further improvement is needed.
分类： 生物学 >> 生物物理学 >> 肿瘤学 提交时间： 2016-05-11
Wang, Fei
Yang, Li
Gao, Qun
Huang, Lan
Zhang, Yi
Wang, Fei
Zhang, Yi
Gao, Qun
Wang, Liping
Zhang, Yi
Wang, Jing
Wang, Shengdian
Zhang, Bin
摘要： Malignant pleural effusion (MPE) is a common complication caused by malignant diseases. However, subjectivity, poor sensitivity, and substantial false-negative rates of cytology assay hamper accurate MPE diagnosis. The aim of this study was to assess whether CD163+CD14+ tumor-associated macrophages (TAMs) could be used as a biomarker for enabling sensitive and specific MPE diagnosis. Pleural effusion samples and peripheral blood samples were collected from 50 MPE patients and 50 non-malignant pleural effusion (NMPE) patients, respectively. Flow cytometry was performed to analyze cell phenotypes, and RT-qPCR was used to detect cytokine expression in these monocytes and macrophages. A blinded validation study (n = 40) was subsequently performed to confirm the significance of CD163+CD14+ TAMs in MPE diagnosis. Student's t test, rank sum test, and receiver operating characteristic curve analysis were used for statistical analysis. Notably, CD163+CD14+ cell frequency in MPE was remarkably higher than that in NMPE (P < 0.001). In a blinded validation study, a sensitivity of 78.9 % and a specificity of 100 % were obtained with CD163+CD14+ TAMs as a MPE biomarker. In total (n = 140), by using a cutoff level of 3.65 %, CD163+CD14+ cells had a sensitivity of 81.2 % and a specificity of 100 % for MPE diagnosis. Notably, MPE diagnosis by estimating CD163+CD14+ cells in pleural effusion could be obtained one week earlier than that obtained by cytological examination. CD163+CD14+ macrophages could be potentially used as an immune diagnostic marker for MPE and has better assay sensitivity than that of cytological analysis.
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