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1. chinaXiv:202009.00010 [pdf]

情绪预测偏差的成因及干预

孙琳; 段涛; 陈宁
Subjects: Psychology >> Applied Psychology

情绪预测偏差是一种对未来事件发生时情绪反应的预测和实际体验之间的分离现象。梳理该领域最近十年(2009~2019年)研究文献可知,热点研究主题涉及偏差的现象、成因和干预,相应呈现为三点主要发现:情绪预测偏差十分普遍,情绪预测偏差成因多源,情绪预测偏差可以干预。未来研究应着力关注情绪预测偏差的发生模式和心理机制,着力揭示具体偏差的神经心理机制,并从进化和文化视角综合考察偏差的发生机制。

submitted time 2020-09-07 Hits1325Downloads88 Comment 0

2. chinaXiv:201907.00014 [pdf]

Remedial dosing recommendations for delayed or missed doses of valproic acid in patients with epilepsy based on Monte Carlo simulations

Chenyu,Wang; Jun-jie Ding; Zheng Jiao; Er-qian Yu; Guo-xing Zhu
Subjects: Medicine, Pharmacy >> Clinical Medicine

Objective: Delayed or missed doses are unavoidable in the pharmacotherapy of epilepsy and significantly compromise the efficacy of antiepileptic drug treatment. An inappropriate remedial regimen can cause seizure relapse or serious adverse events. This study investigated the effect of delayed or missed doses on the pharmacokinetics (PK) of valproic acid (VPA) in patients with epilepsy and established remedial dosing recommendations for nonadherent patients. Methods: Monte Carlo simulations are based on all previous population pharmacokinetic models for pediatric, adult and elderly patients with epilepsy. The following four remedial strategies were investigated for each delayed dose: A) A partial dose or a regular dose is taken immediately; a regular dose is taken at the next scheduled time. B) The delayed dose was administered immediately, followed by a partial dose at the next scheduled time. C) The delayed dose and a partial dose are taken; the next scheduled time is skipped, and the regular regimen is resumed. D) Double doses are taken when missed one dose or two doses, and the regular regimen at the subsequent scheduled time is resumed. Results: The recommended remedial dose was related to the delay duration and daily dose. Remedial dosing strategies A and B were almost equivalent, whereas Strategy C was recommended when the delayed dose was close to the next scheduled dose. Strategy D was only suggested for delayed two doses. Conclusion: Simulations provide quantitative insight into the remedial regimens for nonadherent patients, and clinicians should select the optimal regimen for each patient based on the individual's status.

submitted time 2020-09-07 Hits17653Downloads768 Comment 1

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