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1. chinaXiv:201711.02416 [pdf]

Toll-like?receptor?2?costimulation?potentiates?the?antitumor?efficacy?of?CAR?T?Cells.

Lai, Y; Weng, J; Wei, X; Qin, L; Lai, P; Zhao, R; Jiang, Z; Li, B; Lin, S; Wang, S; Wu, Q; Tang, Z; Liu, P; Pei, D; Yao, Y; Du, X; Li, P
Subjects: Biology >> Ecology

Chimeric antigen receptor (CAR) T-cell immunotherapies have shown unprecedented success in treating leukemia but limited clinical efficacy in solid tumors. Here, we generated 1928zT2 and m28zT2, targeting CD19 and mesothelin, respectively, by introducing the Toll/interleukin-1 receptor domain of Toll-like receptor 2 (TLR2) to 1928z and m28z. T cells expressing 1928zT2 or m28zT2 showed improved expansion, persistency and effector function against CD19+ leukemia or mesothelin+ solid tumors respectively in vitro and in vivo. In a patient with relapsed B-cell acute lymphoblastic leukemia, a single dose of 5 * 104/kg 1928zT2 T cells resulted in robust expansion and leukemia eradication and led to complete remission. Hence, our results demonstrate that TLR2 signaling can contribute to the efficacy of CAR T cells. Further clinical trials are warranted to establish the safety and efficacy of this approach.Leukemia advance online publication, 25 August 2017; doi:10.1038/leu.2017.249.

submitted time 2017-11-17 Hits1644Downloads1012 Comment 0

2. chinaXiv:201704.00068 [pdf]

Chlorobenzene vapor assistant annealing method for fabricating high quality perovskite films

He, Y; Hu, ZW; Ren, MD; Ding, CK; Chen, P; Gu, Q; Wu, Q

In this study, chlorobenzene (CB) vapor assistant annealing (VAA) method is employed to make high quality perovskite films and produce high efficiency CH3NH3PbI3-xClx perovskite solar cells. The perovskite films made by this method present several advanta

submitted time 2017-04-06 Hits1038Downloads663 Comment 0

3. chinaXiv:201704.00067 [pdf]

Evaluation of PHBHHx and PHBV/PLA fibers used as medical sutures

He, Y; Hu, ZW; Ren, MD; Ding, CK; Chen, P; Gu, Q; Wu, Q
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

Two types of fibers were prepared by using bio-based materials: a mono-filament made from poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and a multi-filament made from poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and polylactic acid (PLA) b

submitted time 2017-04-06 Hits1148Downloads678 Comment 0

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