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1. chinaXiv:202003.00008 [pdf]

Germline Polymorphisms and Length of Survival of Nasopharyngeal Carcinoma: An Exome-Wide Association Study in Multiple Cohorts

Yun-Miao Guo; Jie-Rong Chen; Yan-Chun Feng; Chua, Melvin L. K. ; Zeng, Yanni ; Edwin Pun Hui; Allen K. C. Chan; Lin-Quan Tang; Lin Wang; Qian Cui; Hui-Qiong Han; Chun-Ling Luo; Guo-Wang Lin; Yan Liang; Yang Liu; Zhong-Lian He; Yu-Xiang Liu; Pan-Pan Wei; Chu-Jun Liu; Wan Peng
Subjects: Medicine, Pharmacy >> Clinical Medicine
Subjects: Biology >> Genetics

Germline polymorphisms have been linked with differential survival outcomes in cancers but have not been well studied in nasopharyngeal carcinoma (NPC). Here, two-phase association study is conducted to discover germline polymorphisms that are associated with the prognosis of NPC. The discovery phase includes two consecutive hospital cohorts of patients with NPC from Southern China. Exome-wide genotypes at 246,173 single nucleotide polymorphisms (SNPs) are determined, followed by survival analysis for each SNP under Cox proportional hazards regression model. Candidate SNP is replicated in another two independent cohorts from Southern China and Singapore. Meta-analysis of all samples (n = 5,553) confirm that the presence of rs1131636-T, located in the 3′-UTR of RPA1, confers an inferior overall survival (HR = 1.33, 95% CI = 1.20-1.47, P = 6.31 × 10-8). Bioinformatics and biological assays show that rs1131636 has regulatory effects on upstream RPA1. Functional studies further demonstrate that RPA1 promoted the growth, invasion, migration, and radioresistance of NPC cells. Additionally, miR-1253 has been identified as a suppressor for RPA1 expression, likely through regulation of its binding affinity to rs1131636 locus. Collectively, these findings provide a promising biomarker aiding in stratifying patients with poor survival, as well as a potential drug target for NPC.

submitted time 2020-03-06 Hits42161Downloads2935 Comment 0

2. chinaXiv:202002.00062 [pdf]

Furin, a potential therapeutic target for COVID-19

Hua Li; Canrong Wu; Yueying Yang; Yang Liu; Peng Zhang; Yali Wang; Qiqi Wang; Yang Xu; Mingxue Li; Mengzhu Zheng; Lixia Chen
Subjects: Medicine, Pharmacy >> Pharmacology

A novel coronavirus (SARS-CoV-2) infectious disease has broken out in Wuhan, Hubei Province since December 2019, and spread rapidly from Wuhan to other areas, which has been listed as an international concerning public health emergency. We compared the Spike proteins from four sources, SARS-CoV-2, SARS-CoV, MERS-CoV and Bat-CoVRaTG13, and found that the SARS-CoV-2 virus sequence had redundant PRRA sequences. Through a series of analyses, we propose the reason why SARS-CoV-2is more infectious than other coronaviruses. And through structure based virtual ligand screening, we foundpotentialfurin inhibitors, which might be used in the treatment of new coronary pneumonia.

submitted time 2020-02-23 Hits175042Downloads25718 Comment 0

3. chinaXiv:201711.02259 [pdf]

Probing Primordial Gravitational Waves: Ali CMB Polarization Telescope

Hong Li; Si-Yu Li; Yang Liu; Yong-Ping Li; Yifu Cai; Mingzhe Li; Gong-Bo Zhao; Cong-Zhan Liu; Zheng-Wei Li; He Xu; Di Wu; Yong-Jie Zhang; Zu-Hui Fan; Yong-Qiang Yao; Chao-Lin Kuo; Fang-Jun Lu; Xinmin Zhang
Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.

In this paper, we will give a general introduction to the project of Ali CMB Polarization Tele-scope (AliCPT), which is a Sino-US joint project led by the Institute of High Energy Physics (IHEP) and has involved many di erent institutes in China. It is the rst ground-based cosmic microwave background (CMB) polarization experiment in China and an integral part of China's Gravitational Waves Program. The main scienti c goal of AliCPT project is to probe the primor-dial gravitational waves (PGWs) originated from the very early Universe. The AliCPT project includes two stages. The rst stage referred to as AliCPT-1, is to build a telescope in the Ali region of Tibet with an altitude of 5,250 meters. Once completed, it will be the worldwide highest ground-based CMB observatory and open a new window for probing PGWs in northern hemisphere. AliCPT-1 telescope is designed to have about 7,000 TES detectors at 90GHz and 150GHz. The second stage is to have a more sensitive telescope (AliCPT-2) with the number of detectors more than 20,000. Our simulations show that AliCPT will improve the current constraint on the tensor-to-scalar ratio r by one order of magnitude with 3 years' observation. Besides the PGWs, the AliCPT will also enable a precise measurement on the CMB rotation angle and provide a precise test on the CPT symmetry. We show 3 years' observation will improve the current limit by two order of magnitude.

submitted time 2017-11-10 Hits2660Downloads1582 Comment 0

4. chinaXiv:201609.01065 [pdf]

Cosmic Reionization Study : Principle Component Analysis After Planck

Yang Liu; Hong Li; Si-Yu Li; Yong-Ping Li; Xinmin Zhang
Subjects: Physics >> Nuclear Physics

The study of reionization history plays an important role in understanding the evolution of our universe. It is commonly believed that the intergalactic medium (IGM) in our universe are fully ionized today, however the reionizing process remains to be mysterious. A simple instantaneous reionization process is usually adopted in modern cosmology without direct observational evidence. However, the history of ionization fraction,?xe(z)?will influence cosmic microwave background (CMB) observables and constraints on optical depth?τ. With the mocked future data sets based on featured reionization model, we find the bias on?τ?introduced by instantaneous model can not be neglected. In this paper, we study the cosmic reionization history in a model independent way, the so called principle component analysis (PCA) method, and reconstruct?xe(z)?at different redshift?z?with the data sets of Planck, WMAP 9 years temperature and polarization power spectra, combining with the baryon acoustic oscillation (BAO) from galaxy survey and type Ia supernovae (SN) Union 2.1 sample respectively. The results show that reconstructed?xe(z)?is consistent with instantaneous behavior, however, there exists slight deviation from this behavior at some epoch. With PCA method, after abandoning the noisy modes, we get stronger constraints, and the hints for featured?xe(z)?evolution could become a little more obvious.

submitted time 2016-09-19 Hits3166Downloads1420 Comment 0

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