摘要：It has been demonstrated that visual attention is guided by information actively maintained in working memory (WM). However, it remains unknown whether other operations (e.g. inhibition) on WM contents influence selective attention. This issue was investigated in a visual search task where WM contents with either operation (maintenance or inhibition) appeared as distractors in the search display. Behavioral results showed that search performance was slowed down for presenting the maintained contents, but speeded up for the inhibited contents. These results suggested an operation-directed selection of WM contents that visual attention was distinctively influenced by contents with different operation. These observations were further confirmed by the indexes of event-related potentials (ERPs). The inhibited WM contents were suppressed at sensory gating stage (i.e., suppressed P1 amplitude), while the maintained WM contents guided visual attention (i.e., enhanced N2pc amplitude). It seems that results from ERPs and behavior are integrated. The maintained contents guided visual attention that hindered performance of searching a target, while the inhibited contents screened attention that facilitated target searching in the other space. Besides, P3 component indexing updating of WM, which revealed comparable latency both for the maintained and the inhibited WM contents, but with longer latency than the neutral contents. These results suggested that the WM contents with distinct operations were expelled from the focus of executive attention after the onset of the search task, which might be necessary for the WM contents influencing selective attention. The current study reveals that operations of WM contents distinctively affect early selective attention to the matching contents, which sheds some light on the interaction between WM and visual attention.
摘要： Abstract: To face the challenges of keeping healthy in increasing population sizes of both ageing and developing people in China, a fundamental request from the public health is the development of lifespan normative trajectories of brain and behavior. This paper introduces the Chinese Color Nest Project (CCNP 2013–2022), a large-scale tenyear program of modeling brain and behavioral trajectories for human lifespan (6–85 years old). We plan to gradually collect the behavioral and brain imaging data at ages across the lifespan on nationwide and depict the normal trajectory of Chinese brain development across the lifespan, based on the accelerated longitudinal design in the coming next 10 years starting at 2013. Various psychiatric disorders have been demonstrated highly relevant to abnormal events during the neurodevelopment regarding their onset ages of first episodes. Therefore, delineation of normative growth curves of brain and cognition in typically developing children is extremely useful for monitoring, early detecting and intervention of various neurodevelopmental disorders. In this paper, we detailed the developing part of CCNP, devCCNP. It tracked 192 healthy children and adolescents (6–18 years old) in Beibei district of Chongqing for the first 5 years of the full CCNP cohort (2013–2017). To demonstrate the feasibility of implementing the longterm follow-up of CCNP, we here comprehensively document devCCNP in terms of its experimental design, sample strategies, data acquisition and storage as well as some preliminary results and data sharing roadmap for future. Specifically, we first describe the accelerated longitudinal sampling design as well as its exact ratio of sample dropping off during the data collection. Second, we present several initial findings such as canonical growth curves of cortical surface areas of a set of well-established large-scale functional networks of the human brain. Finally, together with records generated by many psychological and behavioral tests, we will provide an individual growing-up report for each family participating the program, initiating the potential guidance on the individual academic and social development. The resources introduced in the current work can provide first-hand data for a series of coming Chinese brain development studies, such as Chinese Standard MRI Brain Templates, Normative Growth Curves of Chinese Brain and Cognition as well as Mapping of Language Areas in Chinese Developing Brain. These would not only offer normative references of the atypical brain and cognition development for Chinese population but also serve as a strong force on accelerating the pace of integrating Chinese brain development into the national brain program or Chinese Brain Project.