分类: 生物学 >> 生物医药 提交时间: 2017-03-30
摘要: Lung cancer is one of the leading causes of death with one of the lowest survival rates. However, a subset of lung cancer patients who are of Asian origin and carry somatic mutations in epidermal growth factor receptor or EGFR have responded remarkable well to two tyrosine kinase inhibitors, gefitinib and erlotinib. While EGFR mutation profiles have been reported from Japan, South Korea, and Taiwan, there is no such report from mainland of China where the largest pool of patients reside. In this report, we identified ten somatic mutations from a total of 41 lung cancer patients in China. Among them, seven mutations were found in 17 adenocarcinomas. In contrast to previous reports, eight of these mutations are deletions in exon 19 and two of these deletions are homozygous. These results suggest that a large portion of Chinese adenocarcinoma patients could benefit from gefitinib or erlotinib. This unique mutation profile provides a rationale to develop the next generation of EGFR inhibitors more suitable for the Chinese population.
分类: 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间: 2017-05-02
摘要: We report a screen-printing fabrication process for large area electrowetting display (EWD) devices using polyimide-based materials. The poly(imide siloxane) was selected as hydrophobic insulator layer, and relatively hydrophilic polyimide as grids material. EWD devices that use poly(imide siloxane) as hydro- phobic insulator fabricated with conventional methods showed good and reversible electrowetting per- formance on both single droplet level and device level, which showed its potential application in EWDs. The compatibility of polyimide-based materials (hydrophobic poly(imide siloxane) and hydrophilic poly- imide) guarantee the good adhesion between two layers and the capability of printable fabrication. To this end, the hydrophilic grids have been successfully built on hydrophobic layer by screen-printing directly. The resulting EWD devices showed good switch performance and relatively high yield. Com- pared to conventional method, the polyimide-based materials and method offer the advantages of simple, cheap and fast fabrication, and are especially suitable for large area display fabrication.