分类： 生物学 >> 分子生物学 提交时间： 2024-05-24
摘要： Differential and even opposing functions of two major antioxidant transcription factors Nrf1 and Nrf2 (encoded by Nfe2l1 and Nfe2l2, respectively) are determined by distinctions in their tempospatial positioning, topological repartitioning, proteolytic processing, and biochemical modification, as well as in their shared evolutionary origin. As a matter of fact, the allelopathic potentials of Nrf1 and Nrf2 (both resembling two entangled ‘Yin-Yang’ quanta that comply with a dialectic law of the unity of opposites) are fulfilled to coordinately control redox physiological homeostasis so as to be maintained within the presetting thresholds. By putative exponential curves of redox stress and intrinsic anti-redox capability, there is inferable to exist a set point at approaching zero with the ‘Golden Mean’ for the healthy survival (i.e., dubbed the ‘zero theory’). A bulk of the hitherto accumulating evidence demonstrates that the set point of redox homeostasis is dictated selectively by multi-hierarchical threshold settings, in which the living fossil-like Nrf1 acts as a robust indispensable determinon, whereas Nrf2 serves as a versatile chameleon-like master regulon, in governing the redox homeodynamic ranges. This is attributable to the facts that Nrf2 has exerted certain ‘double-edged sword’ effects on life process, whereas Nrf1 executes its essential physiobiological functions, along with unique pathophysiological phenotypes, by integrating its ‘three-in-one’ roles elicited as a specific triplet of direct sensor, transducer and effector within multi-hierarchical stress responsive signaling to redox metabolism and target gene reprogramming. Here, we also critically reviewed redox regulation of physio-pathological functions from the eco-evo-devo perspectives, through those coding rules (redox code, stress-coping code, and topogenetic code). The evolving concepts on stress and redox stress were also further revisited by scientific principles of physics and chemistry, apart from two novel concepts of ‘oncoprotists’ and ‘reverse central dogma’ being introduced in this interdisciplinary and synthetic review.
分类： 光学 >> 量子光学 提交时间： 2023-02-19
摘要： We demonstrate a blind zone-suppressed and flash-emitting solid-state Lidar based on lens-assisted beam steering (LABS) technology. As a proof-of-concept demonstration, with a design of subwavelength-gap one-dimensional (1D) long-emitter array and multi-wavelength flash beam emitting, the device was measured to have 5%-blind zone suppression, 0.06{\deg}/point-deflection step and 4.2 microsecond-scanning speed. In time-of-flight (TOF) ranging experiments, Lidar systems have field of view of 11.3{\deg}* 8.1{\deg} (normal device) or 0.9{\deg}*8.1{\deg} (blind-zone suppressed device), far-field number of resolved points of 192 and a detection distance of 10 m. This work demonstrates the possibility that a new integrated beam-steering technology can be implemented in a Lidar without sacrificing other performance.
分类： 光学 >> 量子光学 提交时间： 2023-02-19
摘要： Erbium-doped lithium niobate on insulator (Er:LNOI) is a promising platform for photonic integrated circuits as it adds gain to the LNOI system and enables on-chip lasers and amplifiers. A challenge for Er:LNOI laser is to increase its output power while maintaining single-frequency and single (-transverse)-mode operation. In this work, we demonstrate that single-frequency and single-mode operation can be achieved even in a single multi-mode Er:LNOI microring by introducing mode-dependent loss and gain competition. In a single microring with a free spectral range of 192 GHz, we have achieved single-mode lasing with an output power of 2.1 microwatt, a side-mode suppression of 35.5 dB, and a linewidth of 1.27 MHz.
分类： 光学 >> 量子光学 提交时间： 2023-02-19
摘要： Erbium-doped lithium niobate on insulator (Er:LNOI) has attracted enormous interest as it provides gain and enables integrated amplifiers and lasers on the lithium niobate on insulator (LNOI) platform. We demonstrate a highly efficient waveguide amplifier on Er:LNOI. The 2.58-cm long amplifier can achieve 27.94 dB signal enhancement, 16.0 dB internal net gain (6.20 dB/cm), -8.84 dBm saturation power, 4.59 dB/mW power conversion efficiency, and 4.49 dB noise figure at 1531.6 nm. Besides, thorough investigation on the pumping wavelength, pumping scheme, output power and noise figure have been performed to provide a comprehensive understanding on this novel waveguide amplifier. This work will benefit the development of a powerful gain platform and can pave the way for a fully integrated photonic system on LNOI platform.
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