2019-novel coronavirus (2019-nCoV) infections trigger an exaggerated cytokine response aggravating lung injury

• 作者： Yingxia Liu ¹ Cong Zhang ^2,3 Fengming Huang ³ Yang Yang ¹ Fuxiang Wang ¹ Jing Yuan ¹ Zheng Zhang ¹ Yuhao Qin ³ Xiaoyun Li ³ Dandan Zhao ³ Shunwang Li ³ Shuguang Tan ⁴ Zhaoqin Wang ¹ Jinxiu Li ¹ Chenguang Shen ¹ Jianming Li ¹ Ling Peng ¹ Weibo Wu ¹ Mengli Cao ¹ Li Xing ¹ Zhixiang Xu ¹ Li Chen ¹ Congzhao Zhou ² William J. Liu ⁴ Lei Liu ¹ Chengyu Jiang ³
• 作者单位：
  1.  Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
  2.  Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, China.
  3.  The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry, Peking Union Medical College, Beijing, China.
  4.  The NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China
• 通讯作者： William J. Liu  Email:liujun@ivdc.chinacdc.cn Lei Liu  Email:liulei3322@aliyun.com Chengyu Jiang  Email:jiang@pumc.edu.cn
• 提交时间：2020-02-12

摘要: 最近，在中国武汉爆发了肺炎病例，由一种名为2019-CoV的新型冠状病毒引起。我们之前的研究中，根据中国深圳的12例2019-nCoV感染患者的临床特征，所有病例均患有肺炎，一半病例发展为急性呼吸窘迫综合征（ARDS）。本文中，我们针对这12例患者的血浆因子表达谱进行了研究。我们测试了2019-nCoV感染患者血浆中的48个因子的表达，其中38个因子与健康个体相比显着升高；2019-nCoV感染的重症患者血浆中的高细胞因子血症水平显著低于A型流感病毒H7N9感染患者，而略高于细菌感染患者。在这38个细胞因子中，有17个与2019-CoV病毒载量相关，其中的15个（M-CSF，IL-10，IFN-α2，IL-17，IL-4，IP-10，IL-7，IL-1受体拮抗剂，G-CSF，IL-12 （p40），IFN-γ，IL-1α，IL-2，HGF和PDGF-BB）与肺损伤Murray评分高度相关，可用来预测2019-nCoV感染患者的疾病严重程度。我们的研究结果表明，这15种高细胞因子可能是衡量2019-nCoV感染患者疾病严重程度的潜在生物标志物，影响这些信号传递介质的因子可能是针对新型2019-nCoV大流行的潜在药物。

Abstract: A recent outbreak of pneumonia in Wuhan, China was caused by 2019 novel coronavirus (2019-nCoV). Here we reported 12 patients with 2019-nCoV infections in Shenzhen, China; all of them developed pneumonia and half developed acute respiratory distress syndrome (ARDS). We demonstrated the plasma cytokine profiles of these 12 patients. Thirty-eight out of 48 cytokines measured in the plasmas of 2019-nCoV infected patients were significantly elevated compared to healthy individuals. Seventeen cytokines were linked to 2019-nCoV load. Fifteen cytokines, M-CSF, IL-10, IFN-2, IL-17, IL-4, IP-10, IL-7, IL-1ra, G-CSF, IL-12, IFN-γ, IL-1, IL-2, HGF, and PDGF-BB, were strongly associated with lung injury Murray score, and could predict disease severity of 2019-nCoV infections according to area under the curve (AUC) of the receiver-operating characteristics (ROC) calculations. Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines, some of these cytokines could be potential biomarkers of disease severity of 2019-nCoV infections. These findings improve our understanding of the immunopathologic mechanisms of this emerging and still evolving disease and suggest that modulators of cytokine responses could play a therapeutic role in combating the disease. " "

• 来自： 蒋澄宇
• 分类： 生物学 >> 生物化学
• 引用： ChinaXiv:202002.00018 (或此版本 ChinaXiv:202002.00018V1)
  doi:10.12074/202002.00018
  CSTR:32003.36.ChinaXiv.202002.00018.V1
• 推荐引用方式： Yingxia Liu,Cong Zhang,Fengming Huang,Yang Yang,Fuxiang Wang,Jing Yuan,Zheng Zhang,Yuhao Qin,Xiaoyun Li,Dandan Zhao,Shunwang Li,Shuguang Tan,Zhaoqin Wang,Jinxiu Li,Chenguang Shen,Jianming Li,Ling Peng,Weibo Wu,Mengli Cao,Li Xing,Zhixiang Xu,Li Chen,Congzhao Zhou,William J. Liu,Lei Liu,Chengyu Jiang.(2020).2019-novel coronavirus (2019-nCoV) infections trigger an exaggerated cytokine response aggravating lung injury.中国科学院科技论文预发布平台.[ChinaXiv:202002.00018] (点此复制)