分类: 核科学技术 >> 粒子加速器 提交时间: 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要: Induced radioactivity is one of the essential problems in the radiation protection field of proton accelerators. Research on the induced radioactivity of low-energy proton accelerators is highly limited. Given such context, this study investigates the cross section of 63Cu (p, n) 63Zn and 65Cu (p, n) 65Zn in Cu targets at 11 MeV proton accelerators through an activation experiment. The uncertainties of the results are analyzed in detail. Results show that the cross section of the reaction of 65Cu (p, n) 65Zn in the experiment is only 1.36% lower than that of the FLUKA simulation, whereas the reaction of 63Cu (p, n) 63Zn in the experiment is 25.4% higher than that of the FLUKA simulation. Given that the benchmark for the FLUKA code of low-energy proton accelerators is very limited, this study provides a reference in this field.
分类: 生物学 >> 生物物理学 提交时间: 2016-05-11
摘要: Class Ila histone deacetylases (HDACs), such as HDAC4, HDAC5, and HDAC7, provide critical mechanisms for regulating glucose homeostasis. Here we report that HDAC9, another class Ila HDAC, regulates hepatic gluconeogenesis via deacetylation of a Forkhead box 0 (FoxO) family transcription factor, FoxO1, together with HDAC3. Specifically, HDAC9 expression can be strongly induced upon hepatitis C virus (HCV) infection. HCV-induced HDAC9 upregulation enhances gluconeogenesis by promoting the expression of gluconeogenic genes, including phosphoenolpyruvate carboxykinase and glucose-6-phosphatase, indicating a major role for HDAC9 in the development of HCV-associated exaggerated gluconeogenic responses. Moreover, HDAC9 expression levels and gluconeogenic activities were elevated in livers from HCV-infected patients and persistent HCV-infected mice, emphasizing the clinical relevance of these results. Our results suggest HDAC9 is involved in glucose metabolism, HCV-induced abnormal glucose homeostasis, and type 2 diabetes.