分类: 核科学技术 >> 核材料与工艺技术 提交时间: 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要: To detect the prognostic significance of interim 18F-FDG PET/CT SUV (standard uptake value) reduction (SUVmax) associated with Ki67 in patients with diffuse large B cell lymphoma (DLBCL). 47 DLBCL patients underwent PET/CT before initiation and after 24 cycles of chemotherapy were included. The SUVmax of the dominant lesions were calculated. Ki67 positive indices were provided by enzyme-labeled immuno-histochemistry. SPSS17.0 was used for statistical analysis. SUVmax of different groups were compared by t test. Receiver-operator characteristic analysis was performed to determine the optimal cutoff values. Kaplan-Meier analyses of PFS (Progression-free survival) were compared using log-rank test. The average of SUVmax and SUVmax% were 11.53 and 69.10%, respectively. The optimal cutoff values of SUVmax and SUVmax% were 11.45 and 82.92%, respectively. Higher SUVmax and SUVmax% indicated longer PFS (p55% was revealed to be an indicator of shorter PFS (p=0.019). Either SUVmax11.45 or Ki67>55% was defined as an indicator to poor outcome and scored 1 point. The PFS rate was 100% in patients scored 0 point, yet 0% in patients scored 2 points. PFS tended to be shorter along with the score getting higher (p=0.006). SUVmax and Ki67 positive index were both of significance in DLBCL prognosis. The prognostic value may be confirmed when SUVmax was accordant with Ki67.
分类: 物理学 >> 核物理学 提交时间: 2016-08-30
摘要: A new tuner control system of spoke superconducting radio frequency (SRF) cavity has been developed and applied to cryomodule I (CM1) of C-ADS injector I at IHEP. We have successfully implemented the tuner controllerfor the first time and achieved a cavity tuning phase error of 0.7degrees (about 4 Hz peak to peak) in the presence of electromechanical coupled resonance. This paper will present the preliminary experimental results based on the new tuner controller under proton beam commissioning.
分类: 生物学 >> 生物物理学 提交时间: 2016-05-11
摘要: CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently mutated tumour-suppressor gene that functions in a context-dependent manner. Here we show that both targeted mutation and short hairpin RNA (shRNA) silencing of CD24 retard the growth, progression and metastasis of prostate cancer. CD24 competitively inhibits ARF binding to NPM, resulting in decreased ARF, increase MDM2 and decrease levels of p53 and the p53 target p21/CDKN1A. CD24 silencing prevents functional inactivation of p53 by both somatic mutation and viral oncogenes, including the SV40 large T antigen and human papilloma virus 16 E6-antigen. In support of the functional interaction between CD24 and p53, in silico analyses reveal that TP53 mutates at a higher rate among glioma and prostate cancer samples with higher CD24 mRNA levels. These data provide a general mechanism for functional inactivation of ARF and reveal an important cellular context for genetic and viral inactivation of TP53.