分类: 核科学技术 >> 核材料与工艺技术 提交时间: 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要: To detect the prognostic significance of interim 18F-FDG PET/CT SUV (standard uptake value) reduction (SUVmax) associated with Ki67 in patients with diffuse large B cell lymphoma (DLBCL). 47 DLBCL patients underwent PET/CT before initiation and after 24 cycles of chemotherapy were included. The SUVmax of the dominant lesions were calculated. Ki67 positive indices were provided by enzyme-labeled immuno-histochemistry. SPSS17.0 was used for statistical analysis. SUVmax of different groups were compared by t test. Receiver-operator characteristic analysis was performed to determine the optimal cutoff values. Kaplan-Meier analyses of PFS (Progression-free survival) were compared using log-rank test. The average of SUVmax and SUVmax% were 11.53 and 69.10%, respectively. The optimal cutoff values of SUVmax and SUVmax% were 11.45 and 82.92%, respectively. Higher SUVmax and SUVmax% indicated longer PFS (p55% was revealed to be an indicator of shorter PFS (p=0.019). Either SUVmax11.45 or Ki67>55% was defined as an indicator to poor outcome and scored 1 point. The PFS rate was 100% in patients scored 0 point, yet 0% in patients scored 2 points. PFS tended to be shorter along with the score getting higher (p=0.006). SUVmax and Ki67 positive index were both of significance in DLBCL prognosis. The prognostic value may be confirmed when SUVmax was accordant with Ki67.
分类: 物理学 >> 核物理学 提交时间: 2016-09-14
摘要: In order to improve the particle identification capability of the Beijing Spectrometer III (BESIII),t is proposed to upgrade the current endcap time-of-flight (ETOF) detector with multi-gap resistive plate chamber (MRPC) technology. Aiming at extending ETOF overall time resolution better than 100ps, the whole system including MRPC detectors, new-designed Front End Electronics (FEE), CLOCK module, fast control boards and time to digital modules (TDIG), was built up and operated online 3 months under the cosmic ray. The main purposes of cosmic ray test are checking the detectors' construction quality, testing the joint operation of all instruments and guaranteeing the performance of the system. The results imply MRPC time resolution better than 100ps, efficiency is about 98%燼nd the noise rate of strip is lower than 1Hz/(scm2) at normal threshold range, the details are discussed and analyzed specifically in this paper. The test indicates that the whole ETOF system would work well and satisfy the requirements of upgrade.