Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2022-07-20 Cooperative journals: 《中国全科医学》
Abstract： Background Hyperthyroidism is associated with the development of mental diseases, and the neuropathophysiological mechanism is unknown. Objective In this study, resting state functional magnetic resonance imaging (rs-FMRI) was used to analyze the abnormal patterns of spontaneous brain activity in patients with hyperthyroidism, and to explore the neuroimaging characteristics of brain damage in patients with hyperthyroidism. Methods 25 patients with hyperthyroidism were enrolled as the hyperthyroidism group and 28 healthy volunteers with no significant difference in gender, age and education level were enrolled as the control group. All subjects underwent RS-FMRI, which measured fractional low-frequency amplitude of the whole brain ratio (fALFF) to reflect local spontaneous brain activity. The mental health of the subjects was assessed using SCL-90. Correlation method was used to analyze the relationship between mfALFF value and clinical variables and psychological symptoms. Results Compared with the control group, the hyperthyroidism group right cerebellar vermis region 7 (MNI: 3,-75,-27;t=4.3807), left thalamus (MNI: -6,-6,0;t=3.5448), right thalamus (MNI: 6,-3,3;t=4.3559), the left posterior cerebellar lobe (MNI: -39,-81,-27;t=-3.4015), left orbital middle frontal gyrus (MNI: -9,57,0;t=-5.2534) and left inferior frontal gyrus (MNI: -51,15,18;t=-3.7407) reduced the mfALFF value; Correlation analysis showed that mfALFF value of right cerebellar vermis region 7 was negatively correlated with anxiety (P=0.037,r=-0.419) and hostility (P=0.046,r=-0.402) factor scores. Conclusion Abnormal spontaneous activity in the vermis of the right cerebellum may be an important imaging marker of brain damage in patients with hyperthyroidism.
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