分类: 物理学 >> 核物理学 提交时间: 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要: Bio-nanosensors (Bio-NSs) have attracted much attention recently due to their unique properties. Among all of the bio-NSs, the intracellular proton sensor is significant for biomedicine studies and clinic diagnosis. Proton nanosensors (PNSs) with different pH sensitive ranges could satisfy different research requirements. Here we report a facile method to build a PNS with a neutral to basic pH sensitive range, in which the commercial pH indicator, fluoresceinamine (FA), was covalently coupled to the carboxylic-rich amphiphilic polymer (AP) coated gold nanoparticles (AuNPs).