Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-05-08 Cooperative journals: 《中国全科医学》
Abstract： Background The serum reverse triiodothyronine（rT3）values of heart failure patients who died during hospitalization were found significantly higher than the upper limit of the biological reference interval in the clinical work of the author. The prediction of thyroid hormones，especially rT3，on death during hospitalization of heart failure patients was rare reported in the previous studies，it is of great clinical significance to explore the indicators with predictive value for death during hospitalization in patients with heart failure. Objective To investigate the relationship between serum thyroid hormones and prognosis during hospitalization in patients with heart failure. Method A total of 197 patients with heart failure admitted to Dongzhimen Hospital of Beijing University of Chinese Medicine from April 2019 to April 2022 were included in the study. Baseline data of the study subjects were collected by the electronic medical record system. Fasting venous blood of all subjects was collected within 24 h after admission for total triiodothyronine（TT3），total thyroxine（TT4），free triiodothyronine（FT3），free thyroxine（FT4），thyroid stimulating hormone（TSH），rT3 and N-terminal brain natriuretic peptide precursor（NT#2;pro-BNP）. Subjects were divided into death group（n=18）and non-death group（n=179）according to the occurrence of death during hospitalization. Multivariate logistic regression analysis was used to investigate the influencing factors of death during hospitalization in patients with heart failure. Receiver operating curve（ROC curve）was plotted to evaluate the predictive value of related indicators on death during hospitalization in patients with heart failure，and the area under curve（AUC）of each indicator was calculated and compared by Delong test. Result The age and rT3 of death group were higher than those of non-death group，while FT3，TT3 and TSH of death group were lower than those of non-death group，with statistically significant differences（P<0.05）. In the non-death group，66 patients had normal thyroid function，87 patients had low T3 syndrome，15 patients had high FT4 alone，3 patients had high TT4 alone，5 patients had both high TT4 and FT4，1 patient had low TT4 alone，1 patient had high TT3 alone，and 1 patient had high FT3 alone. In the death group，1 patient had normal thyroid function，14 patients had low T3 syndrome，and 3 patients had high FT4 alone. There was significant difference in the incidence of low T3 syndrome between the 2 groups（P<0.05）. The results of multivariate Logistic regression analysis showed that rT3 was an influencing factor for death during hospitalization in patients with heart failure（P<0.05）. ROC curve results showed that the AUC of rT3 was 0.914〔95%CI（0.865，0.962）〕，which was higher than that of age（Z=3.137，P=0.002），FT3（Z=2.389，P=0.017），TT3（Z=2.123，P=0.034）and TSH（Z=3.056，P=0.002）. Conclusion Low T3 syndrome is a risk factor for death during hospitalization in patients with heart failure. Serum rT3 is of high predictive value for the prognostic evaluation of patients with heart failure during hospitalization，which need more attention in clinical work.
Subjects: Biology >> Botany submitted time 2022-03-28 Cooperative journals: 《干旱区研究》
Abstract：短命植物是荒漠生态系统重要的植物类群，其具有多样化的生境，且很多种类还具有异时萌发特性。植物生物量积累和分配能体现其对环境的响应与适应性特征，因此，研究不同环境条件下短命植物生物量分配格局有助于进一步了解短命植物的生存策略。以裸沙春萌（Bare Sand-Spring Germination，BS）、藻结皮春萌（Algal-Spring Germination，AS）、地衣结皮春萌（Lichen-Spring Germination，LS）3种自然结皮生境中萌发的尖喙牻牛儿苗春萌株及裸沙区夏季萌发（Summer Germination in Bare Sand，SG）的尖喙牻牛儿苗夏萌株为研究对象，采用全株挖掘法获取地上和地下生物量，系统对比分析了4个类型间植株生物量分配及异速生长关系的差异性，以探究其资源分配策略的变异性和保守型。结果表明：（1）尖喙牻牛儿苗单株地上、地下及总生物量总体表现为BS>AS>LS=SG的格局，其根冠比则呈SG=LS=AS>BS的特征。（2）BS和SG类型植株地上与地下生物量间为等速生长关系，而AS和LS生境为异速生长关系，但4个类型具有共同的异速生长指数（0.8843）。（3）AS和LS生境尖喙牻牛儿苗根冠比随个体增大均呈异速减小趋势，而BS和SG类型植株根冠比则保持相对恒定。可见，尖喙牻牛儿苗生物量分配会受到外界环境及个体发育的影响，并呈现明显的可塑性，在一定程度上反映了其资源分配的保守性与可塑性的权衡。
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