Subjects: Agriculture, Forestry,Livestock & Aquatic Products Science >> Other Disciplines of Agriculture, Forestry,Livestock & Aquatic Products Science submitted time 2023-05-15 Cooperative journals: 《智慧农业（中英文）》
Abstract： To achieve rapid on-site detection of aflatoxin B1 (AFB1) in agricultural and sideline products, a portable detection system based on differential pulse voltammetry (DPV) and STM32F103ZET6 as the core processor was designed. The system consists of two main parts: hardware detection devices and a mobile App, which are connected through Wi-Fi communication. The hardware detection equipment includes a DPV waveform generation circuit, constant potential circuit, and micro current detection module. The upper computer App was developed in an Android environment and completed tasks such as signal acquisition and data storage. After completing the design, experiments were conducted to verify the accuracy of the constant potential circuit and micro current detection module. The constant potential circuit accurately applied the voltage set by the program to the electrode, with a maximum error of 4 mV. The micro current detection module converts the current into a voltage signal according to the theoretical formula and amplifies it according to the theoretical amplification factor. The laboratory-made AFB1 sensor was used to effectively detect AFB1 in the range of 0.1 fg/ml to 100 pg/ml. The maximum relative error between the test results in the standard solution and the electrochemical workstation CHI760e was 7.37%. Furthermore, peanut oil samples with different concentrations of AFB1 were tested, and the results were compared to the CHI760e detection results as the standard, with a recovery rate of 96.8%~106.0%. Peanut samples with different degrees of mold were also tested and compared with CHI760e, with a maximum relative error of 7.10%.The system's portability allows it to be easily transported to different locations for on-site testing, making it an ideal solution for testing in remote or rural areas where laboratory facilities may be limited. Furthermore, the use of a mobile App for data acquisition and storage makes it easy to track and manage testing results. In summary, this portable detection system has great potential for widespread application in the rapid on-site detection of AFB1 in agricultural and sideline products.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-28 Cooperative journals: 《中国科学院院刊》
Abstract： Intellectual property (IP) is a key in strengthening the integration of sci-tech and financing for the aim of innovation-driven development. Sci-tech activities are a type of investment in nature. Innovative entities can attract investment with high-quality IP, and investors can profit from innovation by investing in IP. This study analyzes the investment nature of sci-tech activities from two periods of research & development and transformation of sci-tech achievements, and analyzes the role of IP in the two periods. Based on practical foundations, the main considerations are put forward from the aspects of national needs, industry characteristics, endowment difference, and target orientation to promote the integration of sci-tech and financing through IP. Furthermore, it is suggested that to take measures from the aspects of IP system establishment, IP storage, IP-based market mode, and IP-related policy.
Subjects: Psychology >> Developmental Psychology submitted time 2023-03-28 Cooperative journals: 《心理科学进展》
Abstract： Impulsivity is a type of risky behavior or tendency of carrying out such behavior without sufficient consideration of its consequences. It could be represented by impulsive behavior-related personality traits and also delaying discounting or proponent response inhibition. A large number of researches have indicated that the impulsive behavior is implicated in the stages of initiation, maintenance, and relapse of drug-seeking behaviors that are involved in drug addiction. However, how impulsivity influence and facilitate the process of drug addiction is yet to be clarified. Analyzing the impulsivity of the different stages of addiction may lead to further understanding. At the beginning stage of drug use, impulsive personality trait plays a role of motivation to facilitate the drug use behavior. Then continuous operant condition learning leads drug users to enter the goal-oriented stage and presents impulsive selection tendency. At the third stage, classical conditional learning promotes the matching of related cues and drug effects, forming a conditioned reflex. Addicts enter the stage of habitual drug use and show stop impulsivity.
Subjects: Psychology >> Social Psychology submitted time 2023-03-27 Cooperative journals: 《心理学报》
Abstract： Impulsivity is a typical characteristic of drug addiction. In addition to the problems of inhibition and executive control, the driving force from multiple dimensions is also an important reason for impulsive drug use. The psychological drive stems from a variety of sources, including reward effect, S-R related cue response through conditioning. Low levels of inhibition are insufficient to resist the effects of the drive. This leads to an unbalanced state, which results in habitual behavior tendency. Impulsivity has both a behavioral and neural basis. Although impulsivity may be a precursor of drug use, long-term use may also damage brain structures and functions related to the inhibition of impulsive behavior. There is an open question about whether these structures and functions recover after withdrawal. In this research we used multiple imaging methods to study the extent of recovery in heroin addicts who had been abstinent for several years on average. Thirty-five abstinent heroin addicts (26 males; average period of abstinence = 43.55 months) and 26 healthy controls (26 males) were recruited using advertisements in the community. The heroin group and the healthy control group were compared on multiple measures of brain structure and function related to inhibition using the imaging methods of voxel-based morphometry (VBM), amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo). Based on the amplitude of low-frequency fluctuation (ALFF), right inferior frontal gyrus (15, 60, -6) was selected as the region of interest in which to study functional connectivity (FC). Heroin addicts showed damage in inhibition-related brain structures and functions an average of 44 months after withdrawal, and the extent of damage was correlated with lifetime dose. (1) Compared to the healthy control group, the heroin group had significantly (a) lower gray matter volume (p = 0.03) and lower whole-brain volume (p = 0.05); (b) lower gray matter in the right superior frontal gyrus (pAlphaSim < 0.01); (c) higher regional homogeneity in right posterior central gyrus and lower regional homogeneity in right middle frontal gyrus of the orbitofrontal cortex (pAlphaSim < 0.01); (d) lower amplitude of low-frequency fluctuation in right inferior frontal gyrus of the orbitofrontal cortex and left hippocampus (pAlphaSim < 0.01); (e) higher functional connectivity between right inferior frontal gyrus of the orbitofrontal cortex and the right caudate, and lower functional connectivity between the right inferior frontal gyrus and right middle temporal gyrus as well left precentral gyrus (pAlphaSim < 0.01). (2) Within the heroin group, higher lifetime dose of heroin was significantly associated with lower gray matter volume in the right middle temporal gyrus and left middle cingulate (pAlphaSim < 0.01). The results showed that compared to healthy controls, heroin addicts had significant damage in brain structure and functions related to impulsivity even after an average period of 44 months of abstinence. In addition, the extent of damage was correlated with the lifetime dose of heroin. These results suggest that heroin addicts could continue to show impulsive behavior even after several years of abstinence, perhaps explaining the high rate of relapse in this population. Future research could test this conclusion by examining correlations between brain damage in areas related to inhibition and behavioral measures of impulsivity after a period of abstinence. The current evidence underscores the need to take impulsivity into account in relapse prevention programs for heroin addicts.
Subjects: Psychology >> Social Psychology submitted time 2023-03-27 Cooperative journals: 《心理学报》
Abstract： Under relevant cues, people who are addicted tend to use drugs with little attention, purpose or cognitive effort, conforming to an automated “habitual” response behavior. When the substance is not available, this habitual response behavior will be transformed into psychological craving. A common goal of addiction treatment is to reduce cue-induced reactivity that has automatic and unconscious features. Based on previous research, this study used a self-report questionnaire, two behavioral experiments, and measures of Event-Related Potentials (ERPs) to explore the characteristics and neural mechanisms of cue-induced reactivity in heroin addicts under drug-related cues. On this basis, a training program using Virtual Reality (VR) technology and an Approach-Avoidance task (AAT) was designed to weaken the association between drug-related cues and automatic drug use behavior. In Study 1, the participants (N= 38) were men who were addicted to heroin (n=19) and a matched sample of healthy controls (n = 19). The Visual Analog Craving Scale (VAS) was used to investigate cue-induced reactivity by self-report. We then assessed ERPs to explore the nature and neural mechanism of cue-induced reactivity. We hypothesized that compared to the healthy controls, the participants who were addicted to heroin would show more cue-induced reactivity in the form of automatic response outside of awareness. Corroborating our hypotheses in Study 1, we proceeded to Study 2. N= 60 men who were addicted to heroin were equally divided into a treatment group (n= 30) and a no-treatment group (n= 30). The treatment was VR-AAT training for 10 sessions over the course of two months, with the goal of reducing or eliminating cue-induced reactivity. Before and after the treatment, VR-AAT and the Craving Automatized Scale-Substances (CAS-S) questionnaire were used to test the difference between the two groups. The results showed that 1) In between-group comparisons, VAS scores were higher in the addicts than in the control group. And in Study 2, the within-group analyses showed that self-reports of drug use behavior being “unconscious” and “involuntary” were significantly correlated with the duration of addiction. 2) In within-group analyses, N1 amplitude was smaller, latency was shorter, and reaction time was longer in response to drug-related cues versus neutral cues. Other between-group analyses of the ERP data, addicts demonstrated smaller N1 amplitude and longer reaction time in response to drug-related cues compared to the healthy controls, and these differences were concentrated in the central regions of the brain (i.e., the parietal lobe). 3) After the VR-AAT training, the physiological index (based on temperature, diastolic pressure and systolic pressure) decreased significantly, and the coefficient of approach bias of AAT [(Avoid behavior RTs drug-related- Approach behavior RTs drug-related) - (Avoid behavior RTs neutral- Approach behavior RTs neutral)] was significantly smaller than before training. The results were the same at a two-month follow-up. Our findings revealed that cue-induced reactivity showed characteristics of being automatic and unconscious, with greater N1 reactivity in sensorimotor and related brain areas. The VR-AAT training was effective in reducing cue-induced reactions among men addicted to heroin, suggesting that this method has potential applied value in treating heroin addiction and in designing relapse prevention programs. This research contributes to the addiction literature in two ways. First, AAT training has been used in the treatment of alcohol addiction, but not for other forms of addiction. This is the first research to use AAT training to treat heroin addiction. Second, the treatment in the current study is the first one to combine AAT with virtual reality technology. The VR-AAT method might also be a feasible approach for other substance abuse treatments, although more experimental evidence would be needed to support this. One limitation of this study was that the basis of automatic drug use behavior and automatic refusing drug use behavior cannot be distinguished. This issue can be investigated in future research.
Subjects: Agriculture, Forestry,Livestock & Aquatic Products Science >> Other Disciplines of Agriculture, Forestry,Livestock & Aquatic Products Science submitted time 2023-02-17 Cooperative journals: 《智慧农业（中英文）》
Abstract： In view of the uneven distribution of airflow inside the multi-air-duct sprayer, the air flow caused by the air outlet is disturbed and the droplet can not be evenly deposited on the fruit tree canopy. In this research, the length parameter of the inner baffle plate of the multi-duct sprayer was optimized. The Computational Fluid Dynamics (CFD) was used to simulate and analyze the internal airflow of the air supply system of the multi-duct sprayer based on Star-CCM+ software. The standard deviations of the wind speed of the wind outlet 1~6 at different guide plates were 0.7468, 0.6776, 1.4441, 5.1305, 4.5768 and 0.8209, respectively. Among them, the standard deviations of wind speed value at Point 1, Point 2 and Point 6 were less than 1, indicating that the change of deflector length has little impact on the speed change. The standard deviations of wind speed value at Point 3, Point 4 and Point 5 were large, indicating that with the change of deflector length, the wind speed at Air outlet 3, Air outlet 4, Air outlet 5 were greatly affected. On this basis, through the response surface analysis of Air outlet 3, Air outlet 4 and Air outlet 5, it was determined that, the length of Deflector 1 as 200 mm, the length of Deflector 2 as 60 mm and the length of Deflector 3 as 50 mm, was the optimal parameter combination. Under the optimal combination parameters, the wind speed values of symmetrical Air outlet 3 and Air outlet 6 were 39.135 and 41.320 m/s, respectively, with a relative deviations of 5.58%. The wind speed values of air outlet 4 and air outlet 5 were 33.022 and 34.328 m/s, respectively, with a relative deviation of 3.95%, which meeting the design requirements of sprayer. The indoor wind speed test results showed that the average wind speed of the upper layer was 15.75 m/s, the average wind speed of the middle layer was 20.83 m/s, and the average wind speed of the lower layer was 28.27 m/s, which met the end speed principle. The wind field was distributed according to the shape of the fruit tree canopy. The wind field of the left and right sides of the sprayer was symmetrical distributed and the air distribution was uniform. The work can provide a reference for the design of multi-duct sprayer.
Subjects: Psychology >> Applied Psychology submitted time 2022-04-13
Abstract：
Under relevant cues, people who are addicted tend to use drugs with little attention, purpose or cognitive effort, conforming to an automated "habitual" response behavior. When the substance is not available, this habitual response behavior will be transformed into psychological craving.
A common goal of addiction treatment is to reduce cue-induced reactivity that has automatic and unconscious features. Based on previous research, this study used a self-report questionnaire, two behavioral experiments, and measures of Event-Related Potentials (ERPs) to explore the characteristics and neural mechanisms of cue-induced reactivity in heroin addicts under drug-related cues. On this basis, a training program using Virtual Reality (VR) technology and an Approach-Avoidance task (AAT) was designed to weaken the association between drug-related cues and automatic drug use behavior.
In Study 1, the participants (N = 38) were men who were addicted to heroin (n =19) and a matched sample of healthy controls (n = 19). The Visual Analog Craving Scale (VAS) was used to investigate cue-induced reactivity by self-report. We then assessed ERPs to explore the nature and neural mechanism of cue-induced reactivity. We hypothesized that compared to the healthy controls, the participants who were addicted to heroin would show more cue-induced reactivity in the form of automatic response outside of awareness.
Corroborating our hypotheses in Study 1, we proceeded to Study 2. N = 60 men who were addicted to heroin were equally divided into a treatment group (n = 30) and a no-treatment group (n = 30). The treatment was VR-AAT training for 10 sessions over the course of two months, with the goal of reducing or eliminating cue-induced reactivity. Before and after the treatment, VR-AAT and the Craving Automatized Scale-Substances (CAS-S) questionnaire were used to test the difference between the two groups.
The results showed that 1) In between-group comparisons, VAS scores were higher in the addicts than in the control group. And in Study 2, the within-group analyses showed that self-reports of drug use behavior being "unconscious" and "involuntary" were significantly correlated with the duration of addiction. 2) In within-group analyses, N1 amplitude was smaller, latency was shorter, and reaction time was longer in response to drug-related cues versus neutral cues. Other between-group analyses of the ERP data, addicts demonstrated smaller N1 amplitude and longer reaction time in response to drug-related cues compared to the healthy controls, and these differences were concentrated in the central regions of the brain (i.e., the parietal lobe). 3) After the VR-AAT training, the physiological index (based on temperature, diastolic pressure and systolic pressure) decreased significantly, and the coefficient of approach bias of AAT [(Avoid behavior RTs drug-related -Approach behavior RTs drug-related) - (Avoid behavior RTs neutral - Approach behavior RTs neutral)] was significantly smaller than before training. The results were the same at a two-month follow-up.
Our findings revealed that cue-induced reactivity showed characteristics of being automatic and unconscious, with greater N1 reactivity in sensorimotor and related brain areas. The VR-AAT training was effective in reducing cue-induced reactions among men addicted to heroin, suggesting that this method has potential applied value in treating heroin addiction and in designing relapse prevention programs. This research contributes to the addiction literature in two ways. First, AAT training has been used in the treatment of alcohol addiction, but not for other forms of addiction. This is the first research to use AAT training to treat heroin addiction. Second, the treatment in the current study is the first one to combine AAT with virtual reality technology. The VR-AAT method might also be a feasible approach for other substance abuse treatments, although more experimental evidence would be needed to support this. One limitation of this study was that the basis of automatic drug use behavior and automatic refusing drug use behavior cannot be distinguished. This issue can be investigated in future research.
Peer Review Status:
Awaiting Review
Subjects: Psychology >> Applied Psychology Subjects: Psychology >> Clinical and Counseling Psychology submitted time 2021-03-26
Abstract： "
Peer Review Status:Awaiting Review
Subjects: Psychology >> Physiological Psychology submitted time 2019-11-08
Abstract： Persons who are addicted are known to show cue-induced responses (such as psychological craving) to drug-related cues. Previous research showed that both tool-related (e.g., syringe) and action-related (e.g., use of the syringe) drug cues can elicit craving. However, whether the two types of drug related cues can elicit the same brain reactivity and similar degree of disinhibition is still unclear, especially because of the scarcity of ERP studies on this topic. Using a behavioral task and the ERP technique, the present study investigated the behavior reactivity and EEG characteristics shown by men addicted to heroin and healthy controls in response to tool-related and action-related drug cues. Participants were 36 men, 19 of whom were addicted to heroin and 17 of whom were healthy non-drug users, matched on age and years of education. Participants engaged in the two-choice Oddball task, which included two conditions: A. the tool condition, with a picture of a “cup” serving as the standard stimulus and pictures of drug-use tools serving as deviant stimuli; B. the action condition, with a picture of “drinking water” serving as the standard stimulus and pictures of drug-use actions serving as deviant stimuli. In this experiment, the probabilities of standard stimuli and deviant stimuli were 70% and 30%. Participants were asked to press different keys on the keyboard in response to standard stimuli and deviant stimuli as rapidly and accurately as possible. Behavioral results indicated that in men who were addicted to heroin, greater disinhibition was seen in a longer reaction time in response to action cues than tool cues. Between-group analyses of the ERP data showed that compared to the healthy controls, men who were addicted to heroin demonstrated a smaller N2 and larger P3 amplitude in response to drug related cues. Moreover, action cues elicited a smaller N2 amplitude in the heroin addicted group than the control group, especially in the frontal, central and central-parietal areas of the brain, and a larger P3 amplitude, especially in the central and parietal areas of the brain. Within-group analyses in just the heroin addicted group showed that the N2 was smaller in response to action cues versus tool cues. Meanwhile, the action cues elicited a larger amplitude of P3 than the tool cues, especially in the central, central-parietal and parietal regions of the brain. These findings provide behavioral and ERP evidence for the hypothesis that different types of drug-related cues produce different cue-induced reactivity. More specifically, drug use action stimuli, which appear to trigger greater disinhibition and greater ERP reactivity in the brain areas associated with motor resonance, should be considered in the treatment of addiction and in relapse prevention.
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