分类： 核科学技术 >> 核材料与工艺技术 提交时间： 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要： In this paper, the safety and efficacy of 131I-labeled mouse/human chimeric monoclonal antibody (131I-chTNT)-mediated radioimmunotherapy are evaluated because the patients have non-uptaking 131I pulmonary metastases from differentiated thyroid carcinoma (DTC). The 16 patients were injected intravenously by 29.63.7 MBqkg1 using 131I-chTNT. The chest computer tomography was performed before treatment, as well as 28 and 70 days after treatment. Responses and safety were assessed during the treatment. The results show that the 131I-chTNT infusion was well tolerated with the 12.5% complete response, 18.8% partial response, 25.0% progressive disease, and the 43.8% stable disease, indicating that most treatment-related adverse effects are mild transient and reversible. The 131I-chTNT is promising for patients with non-uptaking the 131I pulmonary metastases from DTC.
分类： 地球科学 >> 地理学 提交时间： 2021-06-04 合作期刊: 《干旱区科学》
Nirmal M DAHAL
XIONG Donghong
Nilhari NEUPANE
Belayneh YIGEZ
ZHANG Baojun
YUAN Yong
Saroj KOIRALA
LIU Lin
FANG Yiping
摘要： Drought is an inevitable condition with negative impacts in the agricultural and climatic sectors, especially in developing countries. This study attempts to examine the spatial and temporal characteristics of drought and its trends in the Koshi River Basin (KRB) in Nepal, using the standardized precipitation evapotranspiration index (SPEI) over the period from 1987 to 2017. The Mann-Kendall test was used to explore the trends of the SPEI values. The study illustrated the increasing annual and seasonal drought trends in the KRB over the study period. Spatially, the hill region of the KRB showed substantial increasing drought trends at the annual and seasonal scales, especially in summer and winter. The mountain region also showed a significant increasing drought trend in winter. The drought characteristic analysis indicated that the maximum duration, intensity, and severity of drought events were observed in the KRB after 2000. The Terai region presented the highest drought frequency and intensity, while the hill region presented the longest maximum drought duration. Moreover, the spatial extent of drought showed a significant increasing trend in the hill region at the monthly (drought station proportion of 7.6%/10a in August), seasonal (drought station proportion of 7.2%/10a in summer), and annual (drought station proportion of 6.7%/10a) scales. The findings of this study can assist local governments, planners, and project implementers in understanding drought and developing appropriate mitigation strategies to cope with its impacts.
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