Research progress on the mechanism of short-chain fatty acids in neurodegenerative diseases postprint

Abstract: neurodegenerative diseases are a group of diseases caused by the progressive loss of the function or structure of neurons in the central nervous system, although the physical or mental symptoms of neurodegenerative diseases can be alleviated by combined therapy. however, there is no strategy to directly slow down or prevent neurodegenerative diseases. In recent years, studies on the intestinal microbiota-intestine-brain axis have found that intestinal microbiota and their metabolites play an important role in the occurrence and development of nervous system diseases, while short-chain fatty acids, as the main metabolites of intestinal microbiota, is the key transmitter of intestinal-brain communication and has neuroprotective effect on neurodegenerative diseases, but its specific mechanism is not clear. This article mainly reviews the mechanism of short-chain fatty acids on neurodegenerative diseases, in order to provide reference for the treatment of neurodegenerative diseases.