反馈相关负波：一种抑郁症的生物标记物 postprint

Abstract: Feedback-related negativity (FRN) is an Electroencephalogram (EEG) component that reflects an individual’s reward sensitivity. Depression is usually characterized by decreased reward sensitivity. Several cross-sectional studies have found abnormal FRN in patients with major depressive disorder (MDD) and in those at risk of depression. Moreover, longitudinal studies have found that abnormal FRN can predict the onset of adolescent depression and the development of depressive symptoms; in this process, stress and sleep are two essential moderators. This suggests that FRN may have potential value in the diagnosis and classification of depression and the screening and intervention of high-risk groups of depression. Presently, some controversies regarding the psychological function of FRN still exist. In future research, the function and measurement of FRN should be further clarified, and the effects of heterogeneity and comorbidities of depression on FRN should be further examined. We should also focus on the relationship between FRN and depression in the elderly.