Koisio Technology-Produced Water Significantly Increased the Abundance of Beneficial Gut Bacterium and Decreased the Abundance of Harmful Gut Bacterium of Mice

摘要: Increasing evidence has indicated that gut microbiota plays crucial roles in multiple important biological processes such as energy metabolism and immunological functions. Alterations of gut microbiota also contribute significantly to the pathogenesis of a number of diseases. Our previous study has reported that Koisio technology-produced water (KW) led to significantly decreased inflammation and oxidative stress in both cell culture studies and animal studies. In this study we investigated the effects of KW drinking on the gut microbiota of mice, obtaining the following findings: First, KW drinking significantly increased the abundance of several beneficial genera of the gut bacterium including Akkermansia, Faecalibaculum, Ligilactobacillus, Lachnospiraceae and Roseburia; second, KW drinking significantly decreased the abundance of several harmful genera of the gut bacterium including Clostridioides, Escherichia-Shigella, and Enterococcus; and third, KW drinking significantly increased the abundance of Verrocomicrobiota, while it significantly decreased the abundance of Proteobacteria of the gut microbiota.  Moreover, drinking of KW significantly increased the diversity and richness of the gut microbiota.  Collectively, our study has obtained novel findings that KW is capable of not only increasing significantly the abundance of beneficial gut bacterium and decreasing significantly the abundance of harmful gut bacterium, but also increasing the diversity and richness of the gut microbiota of mice.