Mitochondria Transplantation for the Treatment of Sarcopenia

Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-09-21

李伟 尹洪涛 孙永晨 徐卫娟 孙金玲 金晓东

Abstract： Sarcopenia is a comprehensive disease of aging induced decline in skeletal muscle mass and strength and represents a major health challenge for the elderly. Accumulating evidence suggests that mitochondrial dysfunction plays a key role in the pathogenesis of sarcopenia. Lifestyle interventions, such as exercise, nutrition, and medications for sarcopenia are limited, and solutions to maintain and improve skeletal muscle health are urgently proposed. Mitochondrial transplantation (MTP) is an emerging therapeutic tool for the treatment of tissue damage due to mitochondrial dysfunction. Given the role of mitochondria in skeletal muscle function and metabolism, mitochondrial transplantation may be a novel strategy for the treatment of sarcopenia. In this review, we summarize the mitochondrial related molecular mechanisms leading to sarcopenia, discussing mitochondrial transplantation as a possible therapeutic option.

Peer Review Status:Awaiting Review

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