Subjects: Physics >> General Physics: Statistical and Quantum Mechanics, Quantum Information, etc. submitted time 2023-07-04 Cooperative journals: 《中国全科医学》
Abstract： Background Patients with liver cirrhosis complicated by gastroesophageal variceal and rupture hemorrhage have a certain probability of rebleeding events after endoscopic treatment，and the bleeding volume of rebleeding events is greater with higher risk，which seriously affects the survival rates of patients. Objective To investigate the independent risk factorsof rebleeding events within 3 years after endoscopic treatment in cirrhotic patients with gastroesophageal variceal hemorrhage，construct a nomogram risk prediction model and validate it internally. Methods Four hundred and three patients who underwent endoscopic treatment for liver cirrhosis associated gastroesophageal varices at the Tangdu Hospital and Xijing Hospital，Air Force Medical University from 2011-2022 were retrospectively collected and divided into the rebleeding group（n=252） and control group（n=151） based on the presence of rebleeding within 3 years. The general data and auxiliary examination results of the patients between both groups were compared，and the statistically significant factors were included in the multivariate Logistic regression analysis to analyze the independent risk factors. These data were then input into the R language software to construct a nomogram risk prediction model by using a specific program package. Results Multivariate Logistic regression analysis showed that smoking〔OR=2.499，95%CI（1.232，5.066），P=0.011〕，portal vein internal diameter〔OR=1.047，95%CI（1.028，1.066），P<0.001〕，serum sodium concentration〔OR=0.649，95%CI（0.562，0.750），P<0.001〕 and endoscopic red sign〔OR=3.023，95%CI（1.341，6.814），P=0.008〕 were influencing factors of rebleeding events within 3 years after endoscopic treatment in cirrhotic patients with gastroesophageal variceal hemorrhage. A nomogram prediction model for rebleeding within 3 years after endoscopic treatment was subsequently constructed，and the area under the receiver operating characteristic（ROC） curve was 0.900〔95%CI（0.876，0.929）〕 with sensitivity and specificity of 0.927 and 0.750，respectively. Conclusion Serum sodium level，positive endoscopic red sign，smoking，and enlarged portal vein internal diameter are independent risk factors for rebleeding events within three years after endoscopic treatment in cirrhotic patients with gastroesophageal variceal hemorrhage. The nomogram prediction model exhibited a good fit with an area under the ROC curve of 0.900，showing its high-quality predictive value.
Subjects: Psychology >> Developmental Psychology submitted time 2021-04-28
Abstract： Abstract：Since the 1980s, narcissism has become more and more popular in research. Narcissism may be important for developing self-consciousness and guiding the future. Temperament is the basis for the formation and development of personality, and an important susceptibility factor for the formation of narcissistic personality. Numerous studies have explored the relationship between narcissism and BIS/BAS. However, these results are far from consistency. Therefore, this meta-analysis was conducted to explore the relation between narcissism and BIS/BAS and investigate the moderating effects of measurement tools of narcissism, participant types, age and gender. Through literature retrieval, 25 independent effect sizes together with 7702 participants which met the inclusion criteria of meta-analysis were selected. Homogeneity test indicated that random effects model was appropriate for the meta-analysis. The results of funnel plot and Egger’s intercept illustrated no publication bias. Main-effect test indicated a significant negative correlation between narcissism and BIS (r = –0.27, 95%CI = [–0.34, –0.21]). Further moderation analysis revealed that the association between narcissism and BIS was moderated by measurement tools of narcissism; Main-effect test indicated a significant positive correlation between narcissism and BAS (r = 0.46, 95%CI = [0.40, 0.52]). Further moderation analysis revealed that the association between narcissism and BAS was moderated by participant types. The results supported the agency model of narcissism and the revised reinforcement sensitivity theory of personality. "
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