Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-10-24 Cooperative journals: 《中国全科医学》
Abstract： Background H-type hypertension seriously affects people's health and quality of life. Currently，the clinical treatment of hypertension mainly selects drugs based on the experience，and the antihypertensive effect is not ideal. It is urgent to explore the pharmacogenetic polymorphisms of antihypertensive drugs and provide individualized medication guidance for hypertensive patients. Objective To investigate pharmacogenetic polymorphisms and the intervention effects of folic acid combined with vitamin D in patients with H-type hypertension in Jinan community，and provide reference for the implementation of integrated precision medicine for hypertension. Methods From June 2020 to June 2022，200 hypertensive patients with poorly controlled blood pressure in 20 community health service centers of Huaiyin District，Jinan City，Shandong Province were randomly selected as the research objects. Before treatment，the gene polymorphisms of five commonly used individualized antihypertensive drugs，including diuretics，β-blockers，angiotensin-converting enzyme inhibitors（ACEI），calcium channel inhibitors（CCB），angiotensin- Ⅱ receptor antagonists（ARB），were detected. Patients were randomly divided into the gene-directed treatment group（genome group）and gene-directed synergistic folic acid and vitamin D treatment group （gene-directed group），with 100 cases in each group. The genome group adjusted the drug according to the characteristics of the detected hypertension gene loci；the gene-directed group received folic acid and vitamin D in addition to the genomic therapy regimen. Sitting systolic and diastolic blood pressures in the morning without antihypertensive drugs were collected from patients at the initial intervention （M0），3 months of intervention （M3），and 6 months of intervention （M6）. Case status， adverse reactions and stroke were recorded，gene sequencing was performed，and serum homocysteine（Hcy）concentration was detected. Pearson correlation analysis or Spearman's rank correlation analysis were used to explore the correlation between sex，age，systolic blood pressure，diastolic blood pressure and Hcy. Results Gender（rs=-0.463），systolic blood pressure（r=0.181） and diastolic blood pressure（r=0.188）were correlated with Hcy level（P<0.05）. Among the 5 antihypertensive drug genes， CYP3A5（A6986G），CYP2C9（c.1075A>C），CYP2D6（c.100C>T）were associated with polymorphism loci of drug metabolism enzyme genes，respectively. ADRB1，ACEI（I/D），AGTR1 and NPPA were associated with the polymorphic loci of drug target sensitivity genes. Genome A6986G:CYP3A5*1/*1（AA），ACEI（I/D）:D/D，C.100 C>T:CYP2D6*1/*1（CC）patients at M3 and M6 had lower diastolic blood pressure than M0，A6986G:CYP3A5a1/a3（AG），ADRB1 C.1165 G>C:GG，c.1075A>C:CYP2C9*1/*3（AC），c.1075A>c:CYP2C9*3/*3（CC）patients at M6 had lower systolic and diastolic blood pressure than M0，A6986G:CYP3A5*3/*3（GG），ADRB1 C.1165 G>C:CC，ACEI（I/D）:I/I，c.1075A>C:CYP2C9*1/*1（AA），AGTR1 C.1166A>c:AA，NPPA T2238C:TT，c.100 C>T:CYP2D6*10/*10（TT）patients at M3 and M6 had lower systolic and diastolic blood pressure than M0，ADRB1 C.1165 G>C:GC，ACEI（I/D）:I/D，c.100 C>T:CYP2D6*1/*10（CT）patients at M6 had lower systolic blood pressure than M0，and lower diastolic blood pressure than M0，the difference was statistically significant（P<0.05）. The results of intergroup comparison of Hcy levels showed that the Hcy level at M3 and M6 in the genome group was lower than the genome group，and the difference was statistically significant（P<0.05）. The results of intra-group comparison showed that Hcy level in the genome group at M6 was lower than M0，Hcy level in the gene-directed group at M3 and M6 was lower than M0，and Hcy level at M6 was lower than M3，the differences was statistically significant（P<0.05）. The results of inter-group comparison of systolic and diastolic blood pressure showed that systolic and diastolic blood pressure of M3 and M6 gene-directed group were lower than the genome group，and the difference was statistically significant（P<0.05）. The results of intra-group comparison showed that systolic and diastolic blood pressure at M6 in the genome group and gene-directed group were lower than M0，and the systolic blood pressure at M6 was lower than M3，and the difference was statistically significant（P<0.05）. Conclusion There are differential expression of hypertension drug-related gene polymorphisms in community#2;based H-hypertensive patients，and the effect of individualized medication is remarkable. And combination therapy of folic acid and vitamin D can significantly reduce the level of H-hypertension.
Subjects: Materials Science >> Materials Science (General) submitted time 2023-03-31 Cooperative journals: 《中国腐蚀与防护学报》
Abstract： The corrosion behavior of pure aluminum A1060 in tropic marine environment was simulated by cyclic immersion test, while the correlation of the corresponding results of indoor cyclic immersion test and outdoor marine atmospheric corrosion test of A1060 was comparatively studied in terms of its corrosion morphology, corrosion products and corrosion kinetics by means of weight loss measurement scanning, electron microscope (SEM), energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD). The results showed that the corrosion morphologies and phase constituents compositions of corrosion products after cyclic immersion test agreed fairly well with those after the real atmospheric test. Thereafter, a prediction model for the C corrosion prediction model of aluminum 1060 in two kinds of marine atmospheric environments, which aims to simulate the atmospheric environments at Wanning and Xisha areas in the South China Sea, was estab-lished built combined with Grey correlation method, while the corresponding arithmetic expressions could be described as follows i.e. TWN=146.7t 1.29 and TXS=862.3t 0.85 respectively.
Subjects: Materials Science >> Materials Science (General) submitted time 2023-03-31 Cooperative journals: 《腐蚀科学与防护技术》
Abstract： Effect of biofilms on corrosion behavior of 5083 Al-alloy (5083AA) in natural seawater was investigated by means of epifluorescence microscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy as well as measurements of open circuit potential, electrochemical impedance spectroscopy and pothentiodynamic polarization curves. Results showed that biofilms could form on the surface of 5083AA in natural seawater and acted as a protective layer for the substrate; moreover, in comparison with those in sterile seawater, the open circuit potential of the alloy was lower and the electron charge resistance (Rct) of the alloy was higher in natural seawater, which may be related with the reduction of cathodic reaction and microbiological corrosion inhibition on the alloy surface respectively. The microbiological corrosion inhibition may be due to the oxygen consumption by bacteria respiration and the existence of protective biofilms. On the other hand, the corrosion of 5083AA alloy could be inhibited in sterile medium to a certain extant, and this may be due to the formation of corrosion products on the alloy surface.
Subjects: Materials Science >> Materials Science (General) Subjects: Geosciences >> Marine Sciences submitted time 2016-11-07 Cooperative journals: 《中国腐蚀与防护学报》
Abstract：摘 要：采用周浸试验模拟了纯铝A1060在我国万宁、西沙两种海洋大气环境的腐蚀行为，用扫描电镜(SEM)、能谱(EDS)、X射线衍射（XRD）、失重法等方法对比了A1060纯铝在室内模拟大气环境和户外实际大气环境中的腐蚀形貌、腐蚀产物、腐蚀动力学之间的相关性。试验结果表明，周浸试验后A1060的腐蚀形貌、腐蚀产物组成、腐蚀动力学规律与实际热带海洋大气环境暴露试验结果相关性较好。结合灰关联法建立了A1060在两种海洋大气环境下的腐蚀寿命预测模型：T_wn=146.7t^1.29，T_xs=862.3t^0.85。
Hits
Hits
Downloads
Comment