Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-03-27 Cooperative journals: 《中国全科医学》
Abstract： Background Pulmonary hypertension（PH）associated with left heart disease（PH-LHD）is the most common form of PH. Studies have shown that serum sodium is associated with the severity and poor prognosis of group 1 PH， but the effect of serum sodium on PH-LHD has rarely been reported. Objective To investigate the relationship between serum sodium and N-terminal pro-brain natriuretic peptide（NT-proBNP）and echocardiographic indexes in PH-LHD patients，and evaluate the effect of serum sodium on the severity and length of stay of PH-LHD，so as to provide theoretical basis for clinical diagnosis and treatment of PH-LHD patients and improvement of hospital turnover. Methods The clinical data of 360 adult inpatients diagnosed with PH-LHD in the First Hospital of Shanxi Medical University from January 2020 to February 2022 were collected. According to the median serum sodium of 139 mmol/L（serum sodium <135 mmol/L is hyposodium），the patients were divided into 3 groups：<135 mmol/L group（n=50），135-139 mmol/L（n=136）and 140-145 mmol/L（n=174）. Spearman correlation analysis was used to explore the correlation of serum sodium level with length of hospital stay，NT-proBNP and echocardiographic indicators. Kaplan-Meier was used to compare the length of hospital stay of PH-LHD patients with different serum sodium levels. Binary Logistic regression analysis was used to investigate the effect of serum sodium levels on the length of hospital stay in PH-LHD patients. Results Age，length of stay，NT-proBNP，left atrial diameter ，right atrium area ，left ventricular ejection fraction and shortening fraction of PH-LHD patients in 3 groups were compared，and the differences were statistically significant（P<0.05）. The length of hospitalization and NT-proBNP of patients in the serum sodium 140-145 mmol/ L group were lower than those in the serum sodium <135 mmol/L group and the serum sodium 135-139 mmol/L group（P<0.05）. Spearman correlation analysis showed that serum sodium level was negatively correlated with length of stay（r=-0.176），NT#2;proBNP（r=-0.135），right ventricular diameter（r=-0.110）and pulmonary artery systolic pressure（r=-0.105）in PH-LHD patients（P<0.05）. The Kaplan-Meier survival showed that there were statistically significant differences between the length of hospital stay among the three groups of PH-LHD patients with different serum sodium levels. Binary Logistic regression analysis showed that increased serum sodium level was a protective factor for longer hospital stay in PH-LHD patients after correcting each control variable（OR=0.916，95%CI=0.859-0.977，P=0.008）. The risk of prolonged hospitalization was elevated in patients with serum sodium <135 mmol/L and those with serum sodium 135-139 mmol/L compared with patients with serum sodium 140- 145 mmol/L. Conclusion Serum sodium level is closely related to the severity of PH-LHD，and decreased serum sodium level is an independent risk factor for the length of hospital stay in PH-LHD patients. It is a potential therapeutic consideration，providing new strategies for the diagnosis and treatment of PH-LHD and hospital turnover.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-07-05 Cooperative journals: 《中国全科医学》
GUO Yunting
HOU Xiaomin
BAI Jianying
CHANG Mingyang
ZHAO Xu
SUN Lin
ZHENG Zhifa
SHI Yiwei
QIN Xiaojiang
Abstract： Background Pulmonary hypertension（PH） is often caused by left heart disease（group 2 PH），which is difficult to diagnose early and with a high mortality rate. Potassium channel dysfunction is a marker of PH，however，the epidemiological data of the disease and the effect of potassium ions on PH still remain unclear. Objective To investigate the correlation of serum potassium level with myocardial markers，echocardiographic indicators and length of hospital stay in patients with group 2 PH，and evaluate the predictive value of serum potassium levels for the severity of group 2 PH，so as to provide the oretical basis for clinical diagnosis and treatment. Methods The clinical data of 400 adult inpatients diagnosed with group 2 PH in the First Hospital of Shanxi Medical University from January 2020 to December 2021 were retrospectively collected as follows：（1） general data：gender，age，body mass index（BMI），length of hospital stay，smoking status，smoking index（SI）and drinking history；（2）underlying diseases（diabetes mellitus，hypertension）；（3） laboratory data：serum potassium level，myocardial markers〔procalcitonin，N-terminal pro-brain natriuretic peptide（NT-proBNP），cardiac troponin I，cardiac troponin T，creatine kinase-MB〕，echocardiographic indicators（left atrial diameter，right ventricular diameter，right atrial area，left ventricular ejection fraction，shortening fraction，peak tricuspid regurgitation velocity，pulmonary artery systolic pressure）. The patients were divided into <3.5 mmol/L group（n=57），3.5-5.5 mmol/L group（n=340）and >5.5 mmol/L group（n=3）according to the serum potassium level.Spearman correlation analysis was used to explore the correlation of serum potassium level with myocardial markers and echocardiographic indicators. Log-rank （Mantel-Cox） test was used to compare the discharge rate of patients with different serum potassium levels. Receiver operating characteristic curve （ROC curve） was plotted to evaluate the predictive value of serum potassium level for the severity of group 2 PH. Results Procalcitonin and NT#2;proBNP levels of patients in the hyperkalemia group were significantly higher than the hypokalemia group（P<0.05）. Correlation analysis showed that serum potassium level was positively correlated with NT-proBNP（rs=0.133），peak tricuspid regurgitation velocity（rs=0.017） and pulmonary artery systolic pressure （PASP）（rs=0.126）（P<0.05）. Serum potassium level was further classified as <3.5 mmol/L，3.0-3.5 mmol/L，4.0-4.9 mmol/L，5.0-5.5 mmol/L，and>5.5 mmol/L to investigate its relationship with length of hospital stay in depth. Log-rank （Mantel-Cox） testresults showed that for group 2 PH patients greater than average hospitalization levels，there was a significant difference in cumulative hospitalization rates among patients with different serum potassium levels（<3.5 mmol/L，3.5-3.9 mmol/L，4.0-4.9 mmol/L，5.0-5.5 mmol/L，>5.5 mmol/L）（P=0.022）. ROC analysis showed that the diagnostic value of serum potassium level for non-mild PH（AUC=0.577，cut-off value=3.91 mmol/L，sensitivity=64.7%，specificity=52.5%） was similar to that of NT-proBNP（AUC=0.585，cut-off value=1 070.69 pg/mL，sensitivity=78.1%，specificity=39.6%），which can effectively predict the severity of group 2 PH. Conclusion Serum potassium level can predict the severity of group 2 PH and the length of hospital stay. Intervention of serum potassium levels may be one of the new approach to prevent and treat PH.
Subjects: Psychology >> Developmental Psychology submitted time 2023-03-28 Cooperative journals: 《心理科学进展》
Abstract： Affective forecasting bias is a type of separation phenomenon between affective forecasting and affective experience. According to the literature from the past decade (2009~2019), the popular research topics involve bias phenomena, causes, and interventions. Accordingly, three main findings are presented: Affective forecasting bias is very common, the causes of bias are extensive, and interventions can be conducted. Future research should especially focus on revealing the mechanism of affective forecasting bias, such as the psychological mechanism of specific biases and neuropsychological mechanism of biases and its evolutionary and cultural mechanisms.
Subjects: Psychology >> Social Psychology submitted time 2023-03-27 Cooperative journals: 《心理学报》
Abstract： Human beings have affective forecasting biases. Dispositional mindfulness may weaken the narrow focus of attention by promoting the expansion of the scope of attention and the association of emotional experience, to better simulate future emotions. For adolescents, schoolwork is an important developmental task as well as an arena for their emotion generation. In the present study, we propose the following hypotheses: Middle school students have academic affective forecasting biases (H1); dispositional mindfulness affects the forecasting bias (H2); and dispositional mindfulness reduces affective forecasting biases by weakening attentional focus (H3). To test these hypotheses, three experiments including field and laboratory situational experiments were conducted.In the first experiment, 267 middle school students completed the Five Factor Mindfulness Questionnaire (FFMQ), and were invited to predict their feelings on achieving or not achieving their goals in the forthcoming midterm exam. After the midterm exam, they were asked to report their actual emotional experience at the moment they were informed of their final scores. In the second experiment, 70 middle school students were divided into two groups—high/low dispositional mindfulness groups—and invited to predict their emotions if they were to succeed or fail in the Word Combination Test (WCT). The test involved randomly giving participants positive or negative feedback. After the test, the participants were asked to report their real emotional experience of the success or failure. In the third experiment, 136 middle school students participated in a field experiment of achievement score feedback. Participants completed the FFMQ and attention focus questionnaires first, and then predicted their emotions regarding the result of the WCT. After completing the WCT, the participants were asked to answer the questionnaire about their emotional experiences.In sum, the results of the three experiments congruently prove the existence of academic affective forecasting biases in adolescents. In addition, the influence of dispositional mindfulness on affective forecasting biases was as follows: whether it was a positive or negative situation, adolescents with higher dispositional mindfulness had relatively smaller affective forecasting biases, while adolescents with lower dispositional mindfulness had relatively larger forecasting biases, but the tendency of overestimating and underestimating the emotional experience was not significant. To confirm this, we conducted a meta-analysis combining the three experimental data. The results showed that the mean effect size of dispositional mindfulness in positive situations (achievement of test goals, success feedback) was d = 0.56, Z = 4.31, p < 0.001; and the mean effect size of dispositional mindfulness in negative situations (unfulfilled test goal, failure feedback) was d = 0.42, Z = 3.47, p < 0.001. Further, dispositional mindfulness reduces the cross-context robustness of academic affective forecasting biases. In addition, in the third experiment, we found that attentional focus played a mediating role in the effect of dispositional mindfulness on affective forecasting biases.This study has two theoretical implications. First, it confirms the existence of affective forecasting biases in middle school students regarding their academics. Second, it reveals the effect of dispositional mindfulness on reducing biases of affective forecasting and its possible mechanism, which could be the amplification-bonding mechanism of mindfulness. In terms of practical implications, the real examination and simulated achievement feedback situations presented in this study are a reflection of real school educational activities and, therefore, have stronger ecological validity.
Subjects: Psychology >> Applied Psychology submitted time 2020-09-07
Abstract： Affective forecasting bias is a type of separation phenomenon between affective forecasting and affective experience. According to the literature from the past decade (2009～2019), the popular research topics involve bias phenomena, causes, and interventions. Accordingly, three main findings are presented: Affective forecasting bias is very common, the causes of bias are extensive, and interventions can be conducted. Future research should especially focus on revealing the mechanism of affective forecasting bias, such as the psychological mechanism of specific biases and neuropsychological mechanism of biases and its evolutionary and cultural mechanisms. "
Peer Review Status:
Awaiting Review
Subjects: Biology >> Bioengineering submitted time 2017-11-26 Cooperative journals: 《中国生物工程杂志》
Abstract：基于嵌合抗原受体-T细胞（CAR-T）的免疫疗法已经成为了一种有效治疗恶性肿瘤的全新疗法。本文通过检索并分析CAR-T领域的专利申请文件，从中获得了国内外专利申请发展趋势、主要专利申请人、专利地区分布情况等信息，分析了该领域中涉及的主要技术分支，并重点综述了获美国FDA批准的首个CAR-T 疗法的所属公司——诺华公司CAR-T技术的研发路线，以及国内主要研究机构的专利布局申请情况。
Subjects: Biology >> Bioengineering submitted time 2017-11-26 Cooperative journals: 《中国生物工程杂志》
Abstract：基于嵌合抗原受体-T细胞（CAR-T）的免疫疗法已经成为了一种有效治疗恶性肿瘤的全新疗法。本文通过检索并分析CAR-T领域的专利申请文件，从中获得了国内外专利申请发展趋势、主要专利申请人、专利地区分布情况等信息，分析了该领域中涉及的主要技术分支，并重点综述了获美国FDA批准的首个CAR-T 疗法的所属公司——诺华公司CAR-T技术的研发路线，以及国内主要研究机构的专利布局申请情况。
Subjects: Materials Science >> Materials Science (General) submitted time 2017-03-31 Cooperative journals: 《腐蚀科学与防护技术》
Abstract：通过对比商业化的抑制剂颜料铬酸锶和改性多聚磷酸锶铝，研究了新型绿色抑制剂颜料-肉桂酸铈对轨道交通用7XXX铝合金的腐蚀抑制行为和含肉桂酸铈环氧涂层的腐蚀防护行为。浸泡实验的结果表明，肉桂酸铈和铬酸锶对铝合金的腐蚀具有优秀的抑制作用。极化曲线（PDS）的结果表明，改性多聚磷酸锶铝在浸泡初期对铝合金具有较强的腐蚀抑制能力，而这种腐蚀抑制能力在浸泡后期弱于肉桂酸铈和铬酸锶。研究了含有1%（wt.%）以上三种抑制剂颜料环氧漆的腐蚀行为，电化学交流阻抗谱（EIS）结果表明，含有1%肉桂酸铈的环氧涂层具有优秀的腐蚀防护能力。
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