Complete Genomics刷新全球基因测序通量记录，实现价格新低

2023年2月7日，在AGBT（Advances in Genome Biology and Technology，基因组生物学技术进展会）上，华大智造旗下公司Complete Genomics重磅发布两款新的测序仪DNBSEQ-T20×2和DNBSEQ-G99，以及一款stLFR试剂盒。

1. DNBSEQ-T20×2作为超高通量测序仪，每年可完成5万例人全基因组测序，创造了全球基因测序仪通量的新纪录，并且单例测序成本低于100美元，实现了最佳的规模成本，为行业构筑了一款超强生产规模的“超级测序工厂”。
2. DNBSEQ-G99 作为G 系列的最新型号，是一款超高速基因测序仪，提供中低范围的通量，使其成为靶向基因测序和小型基因组测序的最佳选择。
3. stLFR (single tube long fragment reads，单管长片段序列)，可为大规模并行测序（MPS）和下一代测序（NGS）的DNA打上了条形码，stLFR 试剂盒与 PCR-free WGS 相结合，能够以实惠的价格提供更完整、更准确的单倍型定相基因组，从而为研究和临床应用制定新的 WGS 标准。

大会期间，Complete Genomics还宣布了其已上市的旗舰测序仪DNBSEQ-T7将以1.5美元/Gb的价格发售，用户以150 美元的价格即可获得高质量的 DNBSEQ 基因组。

转载自：

https://www.prnewswire.com/news-releases/complete-genomics-drops-genome-sequencing-price-to-sub-100-at-agbt-general-meeting-301740723.html）

相关论文推荐阅读（来源ChinaXiv-Global）：

http://global.chinaxiv.org/#/browse/browseList?seachword=DESIGNING%20OF%20CUSTOM%20BARCODES%20FOR%20SEQUENCING%20ON%20THE%20MGI%20PLATFORM

DESIGNING OF CUSTOM BARCODES FOR SEQUENCING ON THE MGI PLATFORM

Keywords: genomics

DOI: 10.1101/2022.09.07.506907

Source: biorxiv

Submit Date:2022-09-08

The recently launched MGI platform (DNBSEQ-G50, -G400 and -T7 sequencers)has been gaining popularity for next-generation sequencing. However, the barcode set for library preparation provided by the manufacturer has certain limitations on the number of samples that can be sequenced at a time and the compatibility of barcodes from different or incomplete sets as well as a ratio between the samples. In this paper, we present a protocol for designing custom barcodes expanding the pre-existing barcode set and demonstrate its performance on the MGI Tech Co. Ltd. (China) machines. We developed a universal "quad method" which allows for simultaneous sequencing of any number of samples up to 252 per lane which is multiple of 4 or 4n+2. Here, we describe this method, its analysis, verification, and integration into the sequencing as well as its validation for sequencing using the DNBSEQ G-400 machine.