Subjects: Library Science，Information Science >> Library Science submitted time 2023-02-11
Abstract：
[Purpose/Significance] Digital literacy is a requisite for citizens to adapt to the digital transformation of society. China's national digital literacy and skills enhancement efforts have been systematically promoted. By exploring the thematic characteristics of U.S. digital literacy policies and analyzing development trends, this paper aims to propose references for the improvement of a localized toolbox for China's digital literacy. [Method/Process] The study sorted the 2015-2022 June U.S. federal government bill and selected 19 samples of digital literacy-related policies. Using Nvivo12 Plus, high-frequency word statistics, co-word analysis, and cluster analysis were conducted. A strategical diagram was drawn to reveal the thematic characteristics and development trends. [Result/Conclusion] This study finds that planning guarantee locates in a strategic position for a long time; financial support-related provisions are more independent and gaining importance in a continuous; resource matching places at the edge of the policy and has a low level of attention. Based on the research results and the Chinese situation, the study points out the enlightenment in three aspects involving coordinated planning of digital literacy strategies, financial support for ICT resource matching, and full coverage of digital literacy education.
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Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To improve the water solubility and biological activity of neoligans (magnolol and honokiol) and test the antitumor activity of the modified compounds. Methods The glycosylated products of magnolol and honokiol were obtained by enzymatic synthesis using a UDP-glycosyltransferase (YjiC) from Bacillus. The products were characterized by high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), and nuclear magnetic resonance (NMR) analysis. MTT assay was used to detect the growth inhibition of 4 human cancer cell lines induced by the compounds. Results We obtained two glucosides of neolignans (magnolol and honokiol) for the first time by enzymatic synthesis using a UDP-glycosyltransferase. Based on the spectroscopic data, the glucosides were identified as magnolol-2- O-β-D-glucopyranoside (1) and honokiol-4'-O-β-D-glucopyranoside (2). Compounds 1-4 exhibited moderate anti-proliferative activities against the 4 human cancer cell lines, with IC 50 values ranging from 9.41 to 111.21 µmol/L. Conclusion The glycoslated products show enhanced water solubility and drug sensitivity against SMMC7721 cells, suggesting their value as potential therapeutic drugs.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-03-31 Cooperative journals: 《中国全科医学》
Abstract： Background Early diagnosis of gastric cancer is essential for patient prognosis. Currently，endoscopic forceps biopsy（EFB） is an important tool for the diagnosis of gastric cancer. However，it has been shown in relevant studies that there are some differences between EFB-based diagnosis and pathological diagnosis after endoscopic submucosal dissection（ESD），resulting in an underestimation of the patient's condition. No related research has been conducted in northern Shaanxi. Objective To calculate the rate of pathological upgrading in gastric mucosal lesions after ESD in five hospitals in northern Shaanxi，and to analyze the factors associated with pathological upgrading. Methods We recruited patients with gastric mucosal lesions who underwent ESD following EFB in five hospitals（Yan'an University Affiliated Hospital，Yan'an People's Hospital，The First Hospital of Yulin，Yan'an Traditional Chinese Medicine Hospital，Zichang People's Hospital） from January 1，2016 to December 30，2021. We classified the pathological results of gastric mucosal lesions into the following categories：chronic gastric inflammatory changes（CIC），low-grade gastric intraepithelial neoplasia（LGIN），high-grade gastric intraepithelial neoplasia（HGIN），early gastric cancer（EGC） and progressive gastric cancer. The difference between EFBbased diagnosis and pathological diagnosis of ESD specimens was analyzed. Pathological upgrading was defined as progression in pathological results. The pathological upgrading in patients with CIC，LGIN or HGIN was counted. The factors associated with pathological upgrading were analyzed. Results A total of 241 patients were included. Seventy-six（31.5%） were found with pathological upgrading after ESD compared with their EFB-based diagnoses. Binary logistic regression analysis showed that endoscopic classification〔 OR=0.134，95%CI（0.029，0.617）〕 and superficial ulceration〔 OR=3.595，95%CI（1.226，10.536）〕 were associated with pathological upgrading in CIC（ P<0.05）. Age〔 OR=3.961，95%CI（1.071，14.650）〕，endoscopic classification〔 OR=0.311，95%CI（0.127，0.765）〕，redness of mucosal surface〔 OR=5.830，95%CI（1.591， 21.355）〕，and number of specimens〔 OR=0.234，95%CI（0.063，0.872）〕 were associated with pathological upgrading in LHIN（ P<0.05）. Lesion size〔 OR=3.143，95%CI （1.003，9.852）〕 was associated with pathological upgrading in HGIN（ P<0.05）.Conclusion Medical workers should be alert to the potential possibility of underestimated pathology in EFB if the lesion is CIC suggested by EFB but is endoscopically classified as flat or concave with surface ulceration. And the potential possibility is also should be considered if there is only one biopsy specimen obtained from a patient aged greater than 60 years，and the lesion is LGIN suggested by EFB，but is endoscopically classified as flat with redness of mucosal surface，and an ESD can be underwent if necessary. Moreover，if a lesion greater than 2 cm in size is HGIN suggested by EFB，which is probably EGC，and an ESD is recommended to verify it.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-01-28 Cooperative journals: 《中国全科医学》
Abstract：
Objective To investigate the pathological upgrading rate of gastric mucosal lesions after endoscopic submucosal dissection in five hospitals in Northern Shaanxi, and to analyze the related factors of pathological upgrading. Methods the data of patients with gastric mucosal lesions who received ESD treatment in five hospitals from January 1, 2016 to December 30, 2021 were retrospectively analyzed, the pathological escalation rate was calculated, and the related factors of pathological escalation were analyzed by statistical methods. Results of the 241 cases collected this time, the pathological escalation rate was 31.54% in ESD group and 32.14% in CIC group，endoscopic classification (OR:0.134, CI:0.029-0.617) and surface ulcer (OR:3.596, CI:1.226-10.536) were related to pathological escalation; The pathological upgrading rate of LGIN group was 32%,age (0R:3.961, CI:1.071-14.650), endoscopic typing (OR:0.331, CI:0.127-0.765), redness of surface (OR:5.830, CI:1.591-21.355) and the number of samples taken (OR:234, CI:0.063-0.872) were related to its pathological upgrading; The pathological upgrading rate of HGIN group was 38.46%, and the size of lesion (OR:3.143, CI:1.003-9.852) was an independent related factor of pathological upgrading. Conclusion If the preoperative biopsy is suggestive of CIC, but the lesions are endoscopically classified as flat or concave with surface ulceration, they should be alert to the possibility that the pathology is underestimated; The preoperative biopsy was suggestive of LGIN, but when the patient was aged > 60 years, the lesion was flat type, the surface of the lesion was red and only 1 block was taken for biopsy, it was not excluded that the preoperative pathology was underestimated and ESD was feasible if necessary; With lesion size > 2cm, the lesion diagnosed as HGIN by preoperative biopsy was likely EGC, and ESD was recommended.
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