Subjects: Biology >> Biochemistry Subjects: Biology >> Molecular Biology submitted time 2024-01-02
Abstract： Objective: Comparison of urine proteome between obese people and normal people.
Methods: Urine samples from obese and normal people were collected and identified by non-label quantitative proteomics using high performance liquid chromatography tandem mass spectrometry (LC-MS/MS). The difference proteins of urine proteome between obese and normal people were screened for protein function and biological pathway analysis. The urine proteome of obese individuals was compared with that of normal people, and the common differential proteins were counted to analyze the protein function and biological pathways. Reported biomarkers of obesity were searched in the urine proteome of obese individuals.
Results: 38 different proteins can be identified in the urine proteome of obese people compared with normal people, some of which have been reported to be related to metabolism and obesity, and the biological processes of differential proteins are also related to metabolism and other processes. 8 common differential proteins in the urine proteome of obese individuals and normal people, among which some proteins have been reported to be related to metabolism and obesity, and the biological processes of differential proteins are also related to metabolism and other processes. Among the differential proteins in the urine proteome of obese individuals compared with the normal people, the reported obesity biomarkers can be matched.
Conclusions: The urine proteome can distinguish the obese people, and the differential proteins in the urine proteome have key proteins that are known to be related to obesity and metabolism, and the biological processes of differential proteins also related biological processes such as nutrition and metabolism. Urine proteome has the potential to explore the pathogenesis of obesity and provide personalized treatment.
Peer Review Status:
Awaiting Review
Subjects: Biology >> Biochemistry Subjects: Biology >> Molecular Biology submitted time 2023-11-16
Abstract： Objective: To compare urine proteome changes in the first two days after mating behavior in male rats.
Methods: The urine samples of Sprague-Dawley rats on the day of mating and the day after mating were collected and analyzed by non-label quantitative proteomics by high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS), and the differential proteins (FC > 1.5 or < 0.67) in the urine proteome were screened. P<0.050) protein function and biological pathways were analyzed.
Results: 43 different proteins were identified in the urine proteome between the day after mating and the day after mating. By searching the Uniprot database and Pubmed database and related literature reports, nearly two-thirds of the differential proteins were associated with spermatogenesis.
Conclusions: The urine proteome changed the day after mating compared to the day after mating, and some of the known functions of the changed proteins were associated with spermatogenesis.
Peer Review Status:Awaiting Review
Subjects: Digital Publishing >> New Media submitted time 2023-10-08 Cooperative journals: 《中国传媒科技》
Abstract：【目的】当前社会正处在5G网络基础设施建设和应用培育的重要时期。站在5G发展的节点和路口展望6G技术，借由深度媒介化的视角，能够为当前乃至今后一段时间的智能媒介化实践提供参考和探索的思路。【方法】文章通过总结5G和6G时代的技术特性、应用前景和社会重塑意义，畅想6G技术形塑下的崭新生态图景：【结果】6G技术赋能下，社会的深度媒介化进程将不断加速，媒介的定义将被改写，媒介的内容更加融合，媒介的边界更加弥散，媒介的网络联结更加互联互通、智能立体，Web3.0和AIGC内容广泛渗透于媒介场景之中。【结论】媒介技术将成为一种底层的“操作系统”，深度改写人的社会性连接、交往、认知与决策行为，媒介技术将更加深刻地介入社会管理与协同、社会生产与消费，实现对社会场景的全方位深层次重塑。
Subjects: Psychology >> Social Psychology submitted time 2023-08-28
Abstract： Marriage is the most stable and lasting traditional form of sexual union in human society and an important part of human culture. Marriage satisfaction is a main indicator for measuring marital success. Marriage satisfaction is affected by social, family, individual and other factors and changes in response to society, family and individuals. Thus, changes in marital satisfaction reflect continuous changes in society. Exploring the relationship between marital satisfaction and social change has important reference significance for understanding psychological changes in Chinese society and individuals.
This cross-temporal meta-analysis assessed 92 studies (59122 husbands and wives) published between 2000 and 2021 that used the Evaluating & Nurturing Relationship Issues, Communication, Happiness (enrich), the Marital Adjustment Test (MAT) and the Quality of Marriage Index (QMI) to measure the marital satisfaction of Chinese couples. The China Comprehensive Social Survey (CGSS) analysis was used to discuss the relationship between social indicators and marital satisfaction based on Bronfenbrenner’s ecosystem theory.
The findings are as follows: (1) the marital satisfaction of Chinese couples significantly positively correlates with the year; (2) at the macro level, improving people's quality of life and reducing the household size will increase marriage satisfaction; while, increasing marital satisfaction will promote the pursuit of a better life among couples and maintain family stability and (3) at the micro level, regarding the association between marital satisfaction and social change, the length of marriage, gender, number of children, and the matching degree of education level do not affect marital satisfaction; however, changes due to the presence of children and the degree of education do. In the model of the relationship between social change and marital satisfaction, macro system factors, micro system factors and era changes interact and jointly affect marital satisfaction. Moreover, marital satisfaction will also react to macrosystem factors and promote the harmonious and stable development of society.
Subjects: Management Science >> Management Engineering submitted time 2023-08-10
Abstract： Abstract:[Objective] To comprehensively construct a new pattern for the root-out of migrant workers' wage arrears and multiply the capacity and effectiveness of smart governance for wage arrears. [Methods] The current situation of wage arrears governance and the "regulatory dilemma" in smart governance for wage arrears are analyzed. Under the framework of social co-governance, domain knowledge engineering model is used as the top-level design method. [Conclusions] An overall layout for the top-level design of smart governance for wage arrears for migrant workers is proposed, including two systems, one goal, two capabilities, three foundations, and one platform.
Peer Review Status:Awaiting Review
Subjects: Biology >> Biochemistry submitted time 2022-04-24
Abstract：
[Objective] To explore the effect of traditional Chinese medicine on the urine proteome of healthy rats.
[Methods] In this study, Intragastric administration rat models were established by two traditional Chinese medicines (Compound Danshen Dropping Pills and Huoxiangzhengqi Oral Liquid). Urine samples were collected from rats before and after intragastric administration. Liquid chromatography-mass spectrometry (LC-MS/MS) was used to screen the urine differential proteins of rats before and after intragastric administration and analyze the biological pathway of differential proteins.
[Results] Urine proteome can reflect the changes before and after 14 days of intragastric administration of Compound Danshen Dropping Pills, and the biological pathways enriched by differential proteins are related to their mechanism of action in the treatment of cardiovascular diseases, such as glycolysis, lipid metabolism.
[Conclusions] Urine proteomics can directly and systematically reflect the overall impact of traditional Chinese medicine on the body, and provides a new method to study the efficacy of traditional Chinese medicine.
Peer Review Status:Awaiting Review
Subjects: Psychology >> Management Psychology submitted time 2022-02-22
Abstract：
With a further deepening of globalization, an increasing number of business leaders now have multicultural experiences. Multicultural experiences refer to an individual’s direct or indirect experiences of encountering or interacting with elements of foreign cultures and/or foreigners. This study aims to explore the impact of multicultural experiences on leaders’ capabilities and development from two levels—leader development and leadership development. First, we investigate the impact of multicultural experiences on leader development (including the individual-level, relational-level and collective-level capabilities) and the underlying mechanisms. Second, we investigate the effects of multicultural experiences on leadership development (including leadership emergence, leadership selection, and leadership effectiveness) and the underlying mechanisms. The results will not just enrich theories relating to leaders’ capabilities and development but also provide implications for global management and international talent fostering practices.
Peer Review Status:Awaiting Review
Subjects: Psychology >> Statistics in Psychology submitted time 2020-10-21
Abstract： Mediation and moderation analyses are commonly used methods for studying the relationship between an independent variable (X) and a dependent variable (Y) in conducting empirical research. To better understand the relationships among variables, there is an increasing demand for a more general theoretical framework that combines moderation and mediation analyses. Recently, statistical analysis of mediated moderation (meMO) effects has become a powerful tool for scientists to investigate complex processes. However, the traditional meMO model is formulated based on the homoscedasticity assumption, which is most likely to be violated when moderation effects exist. In addition, routinely reporting effect sizes has been recommended as the primary solution to the issue of overemphasis on significance testing. Appropriate effect sizes (ES) for measuring meMO effects are very important in reporting and interpreting inferential results. However, there does not exist an effective measure that allows us to answer the question regarding the extent to which a variable Z moderates the effect of X on Y via the mediator variable (M) in the meMO model. The article is organized as follows. First, the two-level moderated regression model proposed by Yuan, Cheng, & Maxwell (2014) was extended to a two-level mediated moderation (2meMO) model with single-level data, the statistical path diagram was structured according to the conceptual model and the equations. Second, several effect sizes were developed for the 2meMO effect by decomposing the total variance of the moderation effect. Third, to estimate the parameters of the 2meMO model and the ES measures of the meMO effects, we developed a Bayesian estimation method to estimate the parameters of the 2meMO model. Fourth, a Monte Carlo simulation study was conducted to evaluate the performance of the 2meMO model and the proposed ES measures against those with the meMO model. Finally, we illustrate the application of the new model and measures with a real data example. The simulation results indicate that the size of bias and MSE for parameter estimates are small under both meMO and 2meMO models whether the homoscedasticity assumption hold or not. The results of the coverage rate of the 95% CI for 〖dif〗_moME following 2meMO is comparable to those following meMO when the variance of moderation error is zero, which is the assumption the meMO model is based. However, when the moderation-error variance is nonzero, 2meMO yields more accurate estimates for 〖dif〗_meMO than meMO does, the advantages of 2meMO over meMO become more obvious as the moderation-error variance increases. The results of Type I error rate indicate that 2meMO controls Type I error rather well, and the rates are close to 0.05 or below 0.05 under all the conditions. However, the Type I error rates of meMO tend to be higher than 0.05 when the moderation-error variance is nonzero. The power rates following the meMO and 2meMO models are comparable for the medium or large sample size, or when there is a large difference in meMO effects. While the value of power following 2meMO is slightly lower than that following meMO at small sample size, this result is mostly due to the inflated Type I error rate of meMO, and larger sample sizes and the smaller moderation-error variances correspond to more accurate estimates of ϕ_meMO^((f)). The results also indicate that, when the homoscedasticity assumption of the meMO model is satisfied, the effect size estimates following the two models are about the same. However, when the moderation-error variance is not zero, the results following 2meMO are more accurate than those following meMO. In summary, the article developed a 2meMO model with single-level data and proposed several measures to evaluate the size of the meMO effect explained by moderator variables in total, directly, or indirectly. The performance of the 2meMO model is compared against that of the traditional meMO model via Monte Carlo simulations. Results indicate that, when the assumption of homoscedasticity holds, 2meMO yields comparable results with those under meMO. When the homoscedasticity assumption is violated, estimates under 2meMO are more accurate than those under meMO. More importantly, the measures of the size of the meMO effect proposed in this article can be used as a supplement to the test of meMO effects and will meet the needs for reporting ES in practice. Consequently, the 2meMO model is recommended for the analysis of mediated moderation, and the effect sizes (ESs) for the interpretation of the effect according to the questions of interest are better reported.
Peer Review Status:Awaiting Review
Subjects: Psychology >> Cognitive Psychology submitted time 2020-08-16
Abstract： By reviewing both behavioral and neuroimaging research, the present article illustrates how processing of information from different sources (i.e., the target event/stimulus, internal cognitive schemas, and external interference) and at different stages (i.e., the encoding, storage, re-activation/reconsolidation and retrieval stages) contributes to false memory. We conclude that false memory may arise from three mechanisms: (1) The lack of distinctive item-specific memory representations that makes it difficult to distinguish targets from related lures; (2) The engagement of cognitive schemas strengthens the memory representations of non-target information (including related lures) in the schemas; and (3) Re-activated memory representations of targets are distorted and modified by external interference. Future research may use updated approaches, e.g., multivariate pattern analysis (MVPA), to further investigate the brain regions responsible for representing item-specific details, the way different types of schema (e.g., event-based script) promote the representations of related lures, and the way re-activation of schema during memory retrieval influences false memory.
Peer Review Status:Awaiting Review
Subjects: Psychology >> Cognitive Psychology submitted time 2020-07-04
Abstract： "
Subjects: Psychology >> Educational Psychology submitted time 2020-02-13
Abstract： " Abstract: Character recognition and dictation are two important skills for literacy at the word level. Because Chinese is a logographic script and characters are visually complex, reading and spelling character are more difficult than learning alphabet language. The development of character recognition and dictation in Chinese has unique characteristics. Many cross-sectional researches investigated how morphological awareness contributed to logographic and alphabet language learning, and its influence on the development of character recognition and dictation. However, few studies explored the relationship between morphological awareness and the development of character recognition and dictation over time. The present four-wave longitudinal research was conducted in two Mandarin Chinese primary schools for two years, with a sample consisting of 127 first grader students. A battery of measures, including nonverbal IQ, phonological awareness, orthographic awareness, morphological awareness (homophone awareness, compound word production) were administered in order to investigate the influential factors of character recognition and dictation development in children. The analysis included an unconditional latent growth model to examine the growth trajectory of character recognition and dictation, and a conditional latent growth model to examine the contribution of morphological awareness to the growth of character recognition and dictation The results of the unconditional latent growth model showed that: (1) the developmental trajectory of character recognition showed linear growth it grew at a constant speed. The developmental trajectory of dictation showed non-linear growth, and the growth took place at a fast pace in the beginning and at a slower pace in the latter half of the development trend. Instead of Matthew effect, a compensation effect existed in both character recognition and dictation development, and the standardized correlation coefficients of intercept and slope for character recognition was -0.33 significantly, and for dictation was -0.89 significantly. (2) Homophone awareness and compound word production predicted significantly the children’s initial level(β=0.40, p＜0.001; β=0.14, p＜0.05 respectively) and the growth rate of character recognition (β=0.28, p＜0.001; β=0.25, p＜0.001 respectively), but not the growth rate in dictation. These results suggest that the growth trajectories were different for character recognition and dictation, and the later growth rates of character recognition and dictation were not decided by initial growth levels. The role of morphological awareness was more significant on the development of character recognition than on the development of dictation from Grade 1 to Grade 2.
Subjects: Library Science，Information Science >> Information Science submitted time 2017-07-13 Cooperative journals: 《智库理论与实践》
Abstract：[目的 /意义]国际化是中国特色新型智库建设的重要任务之一。中国智库作为国际化后来者,有必要学习和借鉴外国智库先行者的国际化成功经验。[方法 /过程]选取国际上不同发展阶段,不同成长模式的10家智库进行深度个案研究,研究资料均来源于各家智库的官方网站。通过资料收集、整理和分析形成单个案例。再在单个案例研究基础上,归纳总结出各类智库国际化成功经验。[结果 /结论]在战略定位上,智库国际化需要全球化视野和布局,需要发挥核心作用的领导人,需要在政府沟通与独立研究之间取得平衡;在运营模式上,智库国际化需要充足的研究经费、高水平的研究人员、高质量的研究成果,以及多种方式的国际合作。
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