Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-01-09
Abstract： Objective: To observe the feasibility and effects of the incremental peritoneal dialysis in patients receiving urgent-start peritoneal dialysis. Methods: This is a single-center retrospective study. ESRD patients who received urgent-start peritoneal dialysis from August 1st2018 through July 31st2021 at the first affiliated hospital of Xi'an Jiaotong University were enrolled to this study. The estimated glomerular filtration rate (eGFR) of all patients was between 4 ~ 6ml/min/1.73m2.According to the difference in the initial dialysis dose, recruited patients were divided into an incremental PD group: initial dialysis dose less than or equal to 6000mlper day, with the dialysis dose being adjusted according to the RRF and dialysis adequacy, and a full-dose PD group: dialysis dose more than or equal to 8000ml per day. Patients were followed-up for 1 year. Clinical biochemical indices, dialysis dose, dialysis adequacy, urine volume, dialysis ultra-filtration volume, residual renal function and peritoneal dialysis-related complications were recorded when peritoneal dialysis was performed at 1,3, and 6-months and 1year. Results: 1. This study examined 169 patients, of which, 111 patients with a mean age of 45.01±12.84 years were in the incremental PD group and 58 patients with a mean age of 43.5±15.62 years were in the full-dose PD group. The demographics, the clinical biochemical indices and residual renal function of both groups before peritoneal dialysis were similar(P＞0.05). 2. During follow-up, the dialysis dose in the full-dose PD group exceeded that of the incremental PD group (P<0.05). However, the total Kt/V for both groups exceeded 1.7, and the total Ccr was greater than 50L. At 1 and 6 months, the urine Kt/V in the incremental PD group was higher than that found in the full-dose PD group (P<0.05). 3.During the whole follow-up period, blood pressure control, correction of anemia, and correction of hypocalcemia were also similar for both groups (P>0.05).The correction of hyperphosphatemia in both groups reached the standard.4. During the follow-up period, the residual renal function in both group were similar (P>0.05). The dialysis ultra-filtration volume in the full-dose PD group exceeded that of the incremental PD group, but the differences were not statistically significant (P>0.05).The urine volume of the incremental PD group were significantly higher than that of the full-dose PD group, especially at 1 month and 6 months of dialysis(P<0.05). 5. During the entire follow-up, no patient died in either group. The peritoneal dialysis-related infection, mechanical complications and technical survival rate were similar between groups (P>0.05). Conclusions: The dialysis effect and complications from incremental PD, were similar to full-dose peritoneal dialysis. Incremental PD did not cause a rapid decline of residual renal function in USPD patients. Therefore, USPD patients can be treated by incremental peritoneal dialysis.
Peer Review Status:
Awaiting Review
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-12-30
Abstract： Objective: To observe the feasibility and effects of the incremental peritoneal dialysis in patients receiving urgent-start peritoneal dialysis. Methods: This is a single-center retrospective study. ESRD patients who received urgent-start peritoneal dialysis from August 1st2018 through July 31st2021 at the first affiliated hospital of Xi'an Jiaotong University were enrolled to this study. The estimated glomerular filtration rate (eGFR) of all patients was between 4 ~ 6ml/min/1.73m2.According to the difference in the initial dialysis dose, recruited patients were divided into an incremental PD group: initial dialysis dose less than or equal to 6000mlper day, with the dialysis dose being adjusted according to the RRF and dialysis adequacy, and a full-dose PD group: dialysis dose more than or equal to 8000ml per day. Patients were followed-up for 1 year. Clinical biochemical indices, dialysis dose, dialysis adequacy, urine volume, dialysis ultra-filtration volume, residual renal function and peritoneal dialysis-related complications were recorded when peritoneal dialysis was performed at 1,3, and 6-months and 1year. Results: 1. This study examined 169 patients, of which, 111 patients with a mean age of 45.01±12.84 years were in the incremental PD group and 58 patients with a mean age of 43.5±15.62 years were in the full-dose PD group. The demographics, the clinical biochemical indices and residual renal function of both groups before peritoneal dialysis were similar(P＞0.05). 2. During follow-up, the dialysis dose in the full-dose PD group exceeded that of the incremental PD group (P<0.05). However, the total Kt/V for both groups exceeded 1.7, and the total Ccr was greater than 50L. At 1 and 6 months, the urine Kt/V in the incremental PD group was higher than that found in the full-dose PD group (P<0.05). 3.During the whole follow-up period, blood pressure control, correction of anemia, and correction of hypocalcemia were also similar for both groups (P>0.05).The correction of hyperphosphatemia in both groups reached the standard.4. During the follow-up period, the residual renal function in both group were similar (P>0.05). The dialysis ultra-filtration volume in the full-dose PD group exceeded that of the incremental PD group, but the differences were not statistically significant (P>0.05).The urine volume of the incremental PD group were significantly higher than that of the full-dose PD group, especially at 1 month and 6 months of dialysis(P<0.05). 5. During the entire follow-up, no patient died in either group. The peritoneal dialysis-related infection, mechanical complications and technical survival rate were similar between groups (P>0.05). Conclusions: The dialysis effect and complications from incremental PD, were similar to full-dose peritoneal dialysis. Incremental PD did not cause a rapid decline of residual renal function in USPD patients. Therefore, USPD patients can be treated by incremental peritoneal dialysis.
Peer Review Status:Awaiting Review
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-06-08 Cooperative journals: 《中国全科医学》
Abstract： Background The number of depression patients has exceeded 300 million worldwide，and its high disability rate has attracted global attention. However，the relationship between temperature-humidity index（Humidex） and depression remains to be explored. Objective To explore the relationship between Humidex of the twenty-four solar terms and depression. Methods Outpatient data of depression patients admitted to the psychology department，Mental Health Center of Jiading District from 2016-10-08 to 2019-10-07 were collected，including gender，age，time of treatment，number of outpatient visits and specialist visits. The data of daily mean temperature，relative humidity，rainfall，air pressure and mean wind speed in Jiading District from 2016-10-08 to 2019-10-07 published by Shanghai Meteorological Bureau were collected to calculate Humidex. The included patients were divided into the groups of ≤ 18 years（n=157），19-44 years（n=3 099），45-59 years（n=4 848），60-74 years（n=6 270）and ≥ 75 years（n=3 915）according to different ages. The relationship between Humidex of twenty-four solar terms and depression was estimated by using the combination of nonhomogeneous Poisson distribution and distributed-lag nonlinear model. Correlation between Humidex and meteorological variables was calculated using Pearson correlation analysis. Relative risk rates（RR）of Humidex and depression were calculated of twenty-four solar terms using median Humidex as control. Results A total of 18 289 patients with depression were included from 2016-10-08 to 2019-10-07，including 6 900 males and 11 389 females. The Lesser Cold solar term corresponded to the lowest average Humidex and highest number of depression patients，the Great Heat solar term corresponded corresponded to the highest average Humidex and lowest number of depression patients from 2016-10-08 to 2017-10-07. The Great Cold solar term corresponded to the lowest average Humidex and highest number of depression patients，the Great Heat solar term corresponded to the highest average Humidex and lowest number of depression patients from 2017-10-08 to 2018-10-07. The Great Cold solar term corresponded to the lowest average Humidex and highest number of depression patients，the Great Heat corresponded to the highest average Humidex and lowest number of depression patients from 2018-10-08 to 2019-10-07. Humidex in 24 solar terms showed a nonlinear relationship with the overall population risk of depression. The top two solar terms corresponding to Humidex of depression risk distribution for total population，male，female， ≤ 18 years，19-44 years，45-59 years，60-74 years，and ≥ 75 years were the Great Cold and Beginning of Spring solar terms，Great Heat solar term corresponded to the lowest depression risk distribution. The maximum lag effect was observed on the 10th day of the Great Cold and Beginning of Spring solar terms〔RR=1.020，95%CI（1.001，1.040）〕，and the lag effect was observed on the 8th day of Great Heat solar term and lasted to the 9th day. The lag effect was observed on the 7th day after the Great Cold and Beginning of Spring and the maximum lag effect was observed on the 9th day〔RR=1.054，95%CI（1.007，1.104）〕，which lasted until the 11th day in the 60-74 years group. The lag effect was observed on the 1st day and 8th day after the Great Heat，and lasted to the 2nd day and 10th day，respectively，with the maximum lag effect on the 10th day〔RR=0.952，95%CI（0.911，0.994）〕in male depression patients. The lag effect was observed on the 8th day after the Great Heat solar term and lasted to the 9th day in the 60-74 years group. Conclusion Humidex in the Great Cold and Beginning of Spring solar terms are risk factors for depression，and high Humidex in the Great Heat solar term is a protective factor for depression. Clinically，accurate diagnosis and treatment should be provided for different depression patients according to Humidex in different solar terms，and individualized intervention programs should be formulated.
Subjects: Geosciences >> Other Disciplines of Geosciences submitted time 2019-09-11 Cooperative journals: 《干旱区研究》
Abstract：研究大气水汽的反演及了解其时空变化，对有效评估大气生态服务功能具有重要现实意义。基于石家庄地区CE-318观测的大气水汽数据，结合探空水汽数据和地面水汽压数据，运用传统回归分析、改进型回归分析、分段反演等方法，构建传统回归模型、基于CE-318的大气水汽改进型模型和分季节模型3种大气水汽反演模型，并经过精度对比评估选出适用于研究区的大气水汽最优反演模型。检验结果表明，基于CE-318的大气水汽改进型反演模型的各项精度检验指标均为3个模型中的最佳值，是该地区最优的大气水汽反演模型。
Subjects: Computer Science >> Integration Theory of Computer Science submitted time 2018-11-29 Cooperative journals: 《计算机应用研究》
Abstract： Recommender systems (RS) help users to find interesting information in plenty of data resources, and provide accurate personalized recommendation. While the recommendation algorithm based on information core can greatly reduce the time cost in the recommendation process. Aiming at the scalability problem in collaborative filtering recommendation algorithm, On the basis of the original information core extraction method based on frequency (frequency-based, FB) and ranking (rank-based, RB) , this paper proposes an improved extraction information core method IFB (IFrequency-based) and IRB(IRank-based) . When in search of the most similar neighbors, we proposed a concept : optimization set, and found the most similar neighbors for each user on this set. The experimental results showed that this method can get more accurate recommendation results, and reduce the mean average absolute error(MAE) effectively. At the same time, it has higher precision and recall, so it has better recommendation effect.
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