Subjects: Computer Science >> Integration Theory of Computer Science submitted time 2018-04-19 Cooperative journals: 《计算机应用研究》
Abstract： As a new kind of heuristic swarm intelligence algorithm, the Bird Swarm Algorithm (BSA) easily falls into problems about local optimal, slow convergence speed and low resolution accuracy. Considering the fact that the original Bird Swarm Algorithm is not sufficient to solve the issue in terms of optimization, this paper proposes an optimization algorithm, Dynamic Inertia Weight-Bird Swarm Algorithm (DBSA) . The algorithm corrects birds flying interval by introducing nonlinear dynamic inertia weight, balancing the abilities of population global search and local search; this paper introduces the parameter of levy flight in the process of simulation of the foraging birds producer, advancing algorithm’s vitality and effectiveness via replacing the original algorithm producers foraging strategies. As a result, experiments show that the modified algorithm improves the convergence speed and optimization accuracy effectively.
Subjects: Psychology >> Social Psychology submitted time 2023-03-28 Cooperative journals: 《心理科学进展》
Abstract： As for the conceptualization of mental disorders, the traditional DSM-ICD classification diagnostic system, i.e., Diagnostic and Statistical Manual of Mental Disorders(DSM) and International Classification of Diseases(ICD), as well as the Research Domain Criteria (RDoC) proposed by National Institute of Mental Health(NIMH) are both based on the latent variable perspective, assuming that the symptoms of mental disorders have an underlying common cause(the disorder entity or dysfunction in different potential dimensions). However, such latent variable perspective requires local independency between variables, thus both views ignore the interaction between symptoms. In 2008, Borsboom put forward the psychopathological network theory, a new perspective different from the categorical and dimensional views of the conceptualization of mental disorders. This theory focuses on the interaction between symptoms, assuming that mental disorders are directly composed of symptoms and dynamic causal relationship between them. Based on this theory, network methods mainly estimate the partial correlation network of symptoms using the glasso algorithm with EBIC, and examine the different characteristics of mental disorder symptoms using indicators such as node centrality and network connectivity. In recent years, many new network models have emerged, such as Bayesian networks and relative importance networks that can perform causality inferences. With the increasing number of studies that applied psychopathological network theory and methods, this theory and method has clearly become one of the mainstream research theories and methods in the field of current mental health and psychopathological and psychometrics related research. But at the same time, researchers also found some remaining challenges for psychopathological network methods with respect to causality inference of symptoms, identification of central symptoms, and also reliability and replicability of network structures. Accordingly, this review briefly introduced the core idea and basic principles of psychopathology network theory, as well as the most commonly used psychopathology network analysis methods so far, and summarized important applications and values of psychopathology network theory and methods, then synthesized the main challenges that psychopathological network analysis method were currently facing. Finally, corresponding possible solutions were proposed. After reviewing a wide range of related publishments in theories, methods, and empirical since psychopathology network theory was put forward, we provided unique insights into the possible agendas for future research on psychopathological network methods, hoping the challenges and progress in the methodology could also bring new opportunities for the further improvement of psychopathological network theory.
Subjects: Psychology >> Statistics in Psychology submitted time 2021-04-03
Abstract： "
Peer Review Status:
Awaiting Review
Subjects: Other Disciplines >> Synthetic discipline submitted time 2016-11-26 Cooperative journals: 《中国科学院院刊》
Abstract：心理健康是当今国人最关心的话题之一，人民的心身健康，社会稳定、和谐与可持续发展，都需要以国民心理健康为基础。心理健康是一种高效而满意的心理状态，然而受机体自身和周围环境的影响，心理状态的失衡会引起各种心理健康问题。围绕心理健康问题的发生发展机制及干预策略，国内外已经开展了大量研究。文章主要从心理健康问题识别的角度，系统综述生物-心理-环境等影响因素作用机制，并讨论了新近发展起来的心理健康问题识别和干预新技术。通过对心理健康问题的阐述，希望为系统认识心理健康问题、开展相应评估方法和干预措施提供参考
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-19 Cooperative journals: 《中国科学院院刊》
Abstract： Synthetic biology is an interdisciplinary field that combines life science and engineering to study the mechanism of life, and addresses a wide range of industry sectors and types of applications, such as energy, chemicals, medicine, environment and agriculture. It will also relate public policy issues range across R&D investment and commercialization, education and training, biosafety and biosecurity, intellectual property issues, and public perception. This paper reviews the policies for the development and application of synthetic biology, proposes suggestions for strategic planning, enacting the technical and market standards, the professional training and education，risk assessment and science communication platform, to established innovative policy and governance system.
Subjects: Geosciences >> Atmospheric Sciences submitted time 2023-02-27 Cooperative journals: 《干旱区地理》
Abstract： Solar radiation is the primary energy source of the earth’s system and is closely related to human life. By selecting the monthly sunshine hour data of 50 meteorological observation stations in the Qinghai Plateau of China from 1961 to 2020, the spatiotemporal variation characteristics of sunshine hours in the Qinghai Plateau as a whole, different latitudes, and different altitudes were analyzed. The results are as follows: (1) The annual sunshine hours in the Qinghai Plateau exhibit a significant downward trend from 1961 to 2020, and a sudden decrease occurred in 2004. From the perspective of spatial distribution, the annual sunshine hours in other regions showed a significant decreasing trend except that the sunshine hours in some southern stations is flat or slightly increased. And the decreasing trend is most significant in Qaidam area and eastern agricultural area. (2) The decreasing trend of sunshine hours in high-latitude areas is significantly greater than that in low-latitude areas of the Qinghai Plateau. The variation trend of sunshine hours at different latitudes in spring is small. In summer and winter, the decreasing trend of sunshine hours at relatively high latitudes is significantly greater than that at low latitudes, and in autumn, the decreasing trend of sunshine hours at low and high latitudes is significantly greater than that at middle latitudes. (3) The decreasing trend of annual sunshine hours in relatively low-altitude areas of the Qinghai Plateau is significantly greater than that in relatively high-altitude areas. The change trend of sunshine hours at different altitudes in spring is small, flat, or slightly reduced. The decreasing trend of sunshine hours at relatively low altitudes is significantly greater than that at higher altitudes in summer and winter. The sunshine hours at different altitudes in autumn exhibit a decreasing trend, but there is a significant difference in the decreasing trend.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2018-01-25 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To study the effect of rutin on body weight and obesity-induced reproductive impairment in male mice. Methods Twenty-four male mice were randomized equally into normal control group, high-fat diet group (HFD group), and HFD+rutininterventiongroup(HRUgroup).After28daysoftreatments,thetestesandepididymisofthemicewerecollected for detection of total cholesterol (TC) and triglycerides (TG) levels and for pathological examinations with HE staining. The expressions of related genes was detected with real-time PCR, and Western blotting was used to detect the expression of Ucp1 protein in the samples. Results After 28 days of treatments, the mean body weight was lower in mice with rutin intervention than in those in HFD group. The mice in HFD group showed significantly higher TG levels in the testis and epididymis and higher TC levels in the epididymis than those in the control and HRU groups. In HFD group, the testis and the epididymis displayed loosened structures with abnormalcell structure, and the number ofmature spermatozoa in the lumen was decreased and the mobility of the sperms was reduced; all these changes were significantly alleviated in HRU group. The expression levels of Ucp1 mRNA and protein increased (P<0.05) and the expressions of Mcp1 and TNF-α decreased significantly in the mice after rutin treatment (P<0.05). Conclusion Rutin can effectively inhibit rapid increase of body weight and protect against obesity-inducedreproductiveimpairmentinobesemice.
Subjects: Materials Science >> Materials Science (General) submitted time 2023-03-31 Cooperative journals: 《腐蚀科学与防护技术》
Abstract： Surface aluminized layer was prepared on a Ti2AlNb alloy by double- glow discharge plasma surface technique. The kinetic data of oxidation mass gain were measured for the alloys with and without aluminized layer at 650, 750 and 850 ℃ respectively, and the oxidation rate constants at different temperatures were determined by the relevant linear fitting. The microstructure and phase composition of the formed oxide scale were analyzed by XRD and SEM. It was found that aluminized layer consisted of compact deposited layer and Al-Ti-Nb diffusion layer. At each temperature, the aluminized alloy exhibited parabolic oxidation kinetics and the oxidation rate constant was lower than that of the blank ones. The aluminized layer significantly improved oxidation resistance of Ti2AlNb alloy due to the formation of a dense and continuous Al2O3-rich scale. The inter-diffusion layer provided protection for the substrate from high temperature oxidation and intergranular embrittlement.
Subjects: Other Disciplines >> Synthetic discipline submitted time 2023-03-19 Cooperative journals: 《中国科学院院刊》
Abstract： In the field of medical applications, synthetic biology researchers design genetic circuits to modify human cells, or to modify synthetic organisms such as bacteria and viruses and make them interact with the human body. These artificially designed organisms are capable of perceiving disease-specific signals or artificial signals, targeting abnormal cells and foci, expressing reporter molecules or releasing therapeutic drugs, thus enabling the monitoring of human physiological conditions and the diagnosis and treatment of typical diseases such as tumors, metabolic diseases, and drug-resistant bacteria infections. This article will comprehensively describe some recent research progress.
Subjects: Psychology >> Social Psychology submitted time 2023-03-28 Cooperative journals: 《心理科学进展》
Abstract： Post-traumatic stress disorder (PTSD) is a mental disorder with complex etiologies that usually occurs after people are exposed to traumatic events. In the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the criteria for PTSD included symptoms of intrusion, avoidance, negative alterations in cognitions and mood, and alterations in arousal and reactivity. The World Mental Health Surveys on Trauma and PTSD showed that more than 70% of individuals would experience traumatic events at least once in lifetime, while only a few would develop PTSD, suggesting individual differences in the genesis and development of PTSD. Previous studies have proved that both genetic and environmental factors could influence the risk of PTSD, thus epigenetics, as a discipline investigating the interaction between environment and genes, has attracted the attention of researchers. Among the epigenetic mechanisms, histone modification has received widespread attention and has been researched in depth. Modification of histones by adding one or more chemical groups (such as acetyl group, methyl group, etc.) can lead to changes in chromatin structure and gene transcriptional activity, consequently regulating the level of gene expression. In recent years, histone modification has been implicated as an essential part in the pathogenesis of PTSD for the following reason: the development of PTSD is usually related to the maladaptation of fear memory induced by traumatic events, and histone modification plays an important role in the consolidation and extinction of fear memory correspondingly. At present, techniques commonly used for the measurement of histone modification are Western Blotting and chromatin immunoprecipitation (ChIP), both based on the antibody technology. By combining ChIP with quantitative PCR (qPCR) technology, DNA microarray (also known as gene chip) technology or deep sequencing (Seq) technology, researchers can study the relationship between various types of histone modification and gene expression. What’s more, animal models are the main methods to explore the association between histone modification and PTSD, using electric shocks (e.g., inescapable foot shock, tail shock, and tone shock), social stress (e.g., predator exposure), and single prolonged stress (SPS) to simulate symptoms of PTSD in the laboratory. We systematically searched and screened the literatures of histone modification in PTSD through PubMed (http://www.ncbi.nlm.nih.gov/pubmed/), PsychINFO (http://psycnet.apa.org/), and PsychArticles (http://psycnet.apa.org/), with finally 16 literatures selected for detailed integration and discussion. In spite of the nonnegligible heterogeneity among these studies, they proved the overall effect of histone modification was closely associated with the development of PTSD. Histone modification that enriched in the promoter regions of candidate genes like the Bdnf and Cdk5, could significantly increase the risk of PTSD. Alterations in levels of histone acetylation and methylation in hippocampus, amygdala, and prefrontal cortex are associated with PTSD, playing key roles in the consolidation, reconsolidation, and extinction of fear memory in PTSD-like animals. It is worth noting that histone modification is mainly involved in the regulation of the immune system, the serotonergic system, the neuropeptide Y-ergic system, and the NMDA receptor-related pathways. In addition, histone modification can be regulated by a variety of enzymes, leading to flexible regulation of PTSD, making drugs that target histone modification good choices for clinical treatment of PTSD. Studying the neurobiological mechanisms of PTSD in human patients has been blocked by many factors; moreover, applying the results of animal models of PTSD to clinical research is a long way off. Therefore, using animal models to investigate the role of histone modification in the etiology of PTSD will remain a mainstream approach for some time to come.
Subjects: Psychology >> Applied Psychology Subjects: Biology >> Other Disciplines of Biology submitted time 2021-08-11
Abstract： " " "
Peer Review Status:Awaiting Review
Subjects: Agriculture, Forestry,Livestock & Aquatic Products Science >> Plant Protection submitted time 2018-06-22 Cooperative journals: 《广西植物》
Abstract： Three-dimensional printing (3D Printing) is a technique to manufacture objectives layer by layer with the powder metal or plastic adhesive materials based on the digital model. Due to its flexibility and accuracy, 3D printing has played an important role in military, aerospace and other manufacturing industries. Because of the unique advantages of 3D printing, the application of three-dimensional printing technology in plant reproductive ecology is promising, but is still in an initial stage. This paper summarizes the development of 3D printing technology and floral traits evolution in plant reproductive ecology, and reviews the latest applications of 3D printing technology in researches of plant productive ecology. We also discuss the potential application and direction in the future researches of plant reproductive ecology.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To screen and identify the proteins related with tumor metastasis of gastric cancer in a nude mouse model bearing orthotopic transplanted tumor. Methods Zinc finger protein 139 (ZNF139)-specific siRNA was synthesized and transfected into gastric cancer cell line SGC7901, which was then screened by 6418. ZNF139-siRNA-transfected cells, negative plasmid-transfected cells and untreated SGC7901 cells were orthotopically transplanted separately on the stomach wall of BALB/c nude mice. The primary tumors and metastatic lymph nodes were harvested to separate the proteins by 2-D fluorescence difference gel electrophoresis (2-D DIGE); after gel digestion, the differential proteins were subjected to liquid chromatography-mass spectrometry (LC-MS) for identification and their functions were analyzed. Western blotting was performed to verify the identified proteins. Results ZNF139 expression was effectively inhibited in siRNA-transfected SGC7901 cells. ZNF139-siRNA-transfected cells showed obviously suppressed tumor growth with a lowered lymph node metastasis rate in nude mice compared with untreated cells and the negative control cells (P<0.05). Proteomic study with 2-D DIGE showed that fascin and hnRNPA2/B1 were down-regulated while ANXA1 was up-regulated in the primary tumors, and ANXA5 was down-regulated in the metastatic lymph nodes in ZNF139-siRNA-transfected group. Western blotting confirmed the results of proteomic analysis. Conclusion ZNF139 gene may promote lymph node metastasis of gastric cancer by regulating fascin, hnRNPA2/B1, ANXA1, and ANXA5.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-27 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To investigate the impact of heart valve calcification (HVC) on cardiovascular outcomes in patients on maintenance hemodialysis (MHD). Methods We enrolled 302 Chinese patients on MHD between 2009 and 2011 including 99 with HVC identified by echocardiography screening. All the patients were followed up for 2 years and survival analysis was performed with all-cause mortality, cardiovascular mortality and new onset cardiovascular events as the endpoints. Cox regression analysis was used for analyzing the impact of heart valve calcification on the cardiovascular outcomes of the patients. Results The mean age of the total patients was 58.2�5.0 years when receiving the initial MHD, and 53.6% were male patients. The overall mortality, cardiovascular mortality and new on-set cardiovascular events in HVC and non-HVC groups were 30.3% vs 16.3% , 22.2% vs 6.9% , and 48.5% vs 25.6% , respectively (P<0.05). Kaplan-Meier survival analysis showed a significant difference in all-cause mortality (P=0.006), cardiovascular mortality (P<0.001) and new-onset cardiovascular events (P<0.001) between HVC and non-HVC groups. After adjustment, Cox regression analysis identified HVC as a risk factor for increased all-cause mortality (HR=1.88; 95% CI: 1.11-3.19), cardiovascular mortality (HR=3.47, 95% CI: 1.76-6.84) and cardiovascular events (HR=1.64, 95% CI: 1.09-2.47). Conclusions HVC is an independent risk factor for increased cardiovascular mortality and new cardiovascular events in patients on MHD.
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