Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2024-03-26 Cooperative journals: 《中国全科医学》
Abstract： Background Dapagliflozin is an effective drug for the treatment of type 2 diabetes mellitus（T2DM），which can also reduce the risk of nephropathy progression，decrease urinary protein and protect the heart. However，whether dapagliflozin can reduce the incidence of contrast-induced nephropathy（CIN）after percutaneous coronary intervention（PCI）in T2DM patients remain unclear. Objective To investigate the impact of dapagliflozin on the incidence of CIN in patients with T2DM underwent PCI. Methods According to the principle of 1:1 propensity matching based on the use of dapagliflozin，a total of 484 T2DM patients who underwent PCI in the Department of Cardiology，Tianjin Chest Hospital from January 2021 to December 2023 were retrospectively consecutively enrolled in the study，of which 242 cases were in the dapagliflozin group and 242 cases were in the control group. The pre-PCI clinical data of the two groups were collected and compared，and the renal functions of the two groups were recorded before PCI，48 hours after PCI and 1 week after PCI，including blood urea nitrogen（BUN），serum creatinine（Scr），creatinine clearance rate（Ccr），cystatin C（Cys-C），β-2 microglobulin（β2-MG），and neutrophil gelatinase associated apolipoprotein（NGAL）. The primary study endpoint was the incidence of CIN，and the secondary study endpoint was the change in renal function during the perioperative period of PCI. Multivariate Logistic regression was used to analyze the effect of dapagliflozin on the incidence of CIN after PCI in patients with T2DM. Results The incidence of CIN in patients in the dapagliflozin group was 6.2% lower than that in patients in the control group（12.0%）. The difference was statistically significant（χ2 =4.900，P=0.039）. The CIN risk score and B-type natriuretic peptide of patients in the dapagliflozin group were higher than those in the control group（P<0.05）. There was no statistically significant difference in BUN，Scr，Ccr，Cys-C，β2-MG，and NGAL levels between 2 groups before and 1 week after PCI（P>0.05）. At 48 hours after PCI，the levels of Cys-C，β2-MG，and NGAL in the dapagliflozin group were lower than those in the control group（P<0.05）. Multivariate Logistic regression analysis showed that high CIN risk score（OR=1.213，95%CI=1.085~1.358，P=0.001）and B-type natriuretic peptide levels（OR=0.338，95%CI=1.479~10.494，P=0.006）were independent risk factors for CIN after PCI in patients with T2DM，and the use of dapagliflozin （OR=0.338，95%CI=0.159~0.717，P=0.005） was an independent protective factor for the development of CIN after PCI in patients with T2DM. Conclusion The use of dapagliflozin is an independent protective factor against the development of CIN after PCI in patients with T2DM，and dapagliflozin does not increase the risk of developing acute kidney injury（AKI）after PCI in patients with T2DM and may reduce the incidence of CIN.
Subjects: Physics >> Nuclear Physics submitted time 2024-02-16
LIU Yinshen
YANG Xiaofei
ZHANG Peng
HU Hanrui
BAI Shiwei
WANG Shujing
LIU Yongchao
GUO Yangfan
LIN Zheyang
YAN Zhou
MEI Wencon
CHEN Shaojie
NI Xinyue
XIE Bingqi
YE Yanlin
LI Qite
LI Hongwei
HE Chuangye
YANG Jie
LIU Zuoye
Abstract： The basic properties of atomic nuclei including spins, magnetic moments, electric quadrupole moments and charge radii, are sensitive probes to different aspects of exotic nuclear structure, and are also important to investigate the unrevealed nature of interaction between nucleons. Based on multidiscipline, laser spectroscopy is a unique tool to precisely measure the basic nuclear properties mentioned above in a nuclear-model independent way by measuring the hyperfine structure of atoms, ions, or molecules, which has played an important role in the study of exotic nuclear structures across the different regions of the nuclear chart. Basic principles of laser spectroscopy and various types of experimental devices are expounded after the brief history of the hyperfine structure. Furthermore, advantages of utilizing laser spectroscopy in the study of nuclear structure are briefly introduced by taking the radioactive neutron-deficient Pb region as an illustration. In addition, current condition of collinear laser spectroscopy setup has been systematically reviewed, together with the latest progress on collinear resonance ionization spectroscopy offline devices at Peking University. Finally, the developing status and ongoing plan of laser spectroscopy devices for current and future radioactive ion beam facilities in China have been put forward, and the broad prospects of laser spectroscopy in unstable nuclear properties and the fundamental symmetries based on molecular spectroscopy are interpreted.
Subjects: Digital Publishing >> New Media submitted time 2023-10-08 Cooperative journals: 《中国传媒科技》
Abstract：本文以《木材工业》杂志为例，基于中国知网数据库，系统分析了该刊2006—2020年间刊载的104篇高被引学术论文的被引频次、下载次数、主要作者、合作程度、发文机构、文献类型、关键词，以及下载频次与被引频次的相关性等主要特征，并探讨了高被引论文分析结果在期刊运营中的应用模式，以期为期刊选题策划提供参考，提升期刊学术影响力。
Subjects: Digital Publishing >> New Media submitted time 2023-10-08 Cooperative journals: 《中国传媒科技》
Abstract：随着数字广播电视技术的不断创新发展,数字电视已经完成了由标清到4k技术的过渡。新一代4k技术电视想要实现播放实践一体化,必须依托互联网对播放实践系进行优化改进。本文就4k技术电视播放实践一体化的设计与实现进行分析研究。
Subjects: Digital Publishing >> New Media submitted time 2023-10-08 Cooperative journals: 《中国传媒科技》
Abstract：
Subjects: Materials Science >> Materials Science (General) submitted time 2023-03-18 Cooperative journals: 《材料研究学报》
Abstract： Magnetic characteristics of the as-quenched fully and partially amorphous Al85Ni5Y4Fe2Co2 alloy were measured by VSM (vibrating sample magnetometer). The results show that the magnetization curves of the two alloys pass the origin of coordinates and extend through the first and the third quadrants, no remanence and coercivity were observed. The magnetism of the fully and partially amorphous alloys is all a combination of paramagnetism and diamagnetism. The magnetic susceptibility of the fully amorphous alloy is 2.41×10- 4 and that of the partially amorphous alloy is 2.73×10- 4. The magnetisms of the alloys annealed at 330℃and 390℃ were also tested respectively. The magnetic susceptibility of the linear portion of the magnetization curve increases from 2.53×10-4 to 2.81×10-4 as the annealing temperature rises from 330℃ to 390℃. The hybrid microstructures of the alloys may account for the evolution of the corresponding magnetisms.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-01-30 Cooperative journals: 《中国全科医学》
Abstract：
Background Hyperuricemia (HUA) caused by elevated serum uric acid (SUA) has been proven to be an independent risk factor for the development and progression of chronic kidney disease (CKD). However, there are few cohort studies on the correlation between SUA level and the development and progression of CKD in the Chinese elderly. Objective To investigate the association between baseline SUA level, changes in SUA levels, the risk of chronic kidney disease (CKD), and estimated glomerular filtration rate (eGFR) in the elderly in longevity areas in China. Methods Based on Healthy Aging and Biomarkers Cohort Study (HABCS), a sub cohort of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), the elderly who underwent physical examination and provided biomedical indicators from 2012 to 2014 were selected as the study subjects. The age, gender, height, weight, waist circumference, calf circumference, blood pressure, blood lipid, blood glucose, blood routine examination, urine routine examination, and other medical indicators were collected at baseline and follow-up period. Cox proportional hazards regression model was used to analyze the association between different SUA levels and the risk of CKD. Pearson linear correlation and linear regression were used to analyze the association between changes in SUA level and changes in eGFR in the elderly. Results A total of 981 subjects were included in the study, with an average age of 80.1±11.9 years. The prevalence of HUA was 6.83%. The cumulative follow-up of 2029 person-years (median 2.05 years) showed 179 new cases of CKD, the cumulative incidence rate of CKD during the follow-up was 18.25% (95%CI: 15.88-20.81%), and the incidence density was 88.22/1000 person-years (95%CI: 76.24-101.41 person-years). After multivariate adjustment, compared with the lowest quartile group of baseline SUA level (Q1: < 223 μmol/L), the HR values of CKD risk in other three high quartile groups (Q2: 223-270 μmol/L, Q3: 271-326 μmol/L, and Q4 ≥ 326 μmol/L) were 1.19 (95%CI: 0.74, 1.94; P=0.474)，1.27 (95%CI: 0.76, 2.10; P=0.362), and 2.08 (95%CI: 1.27, 3.41; P=0.004; Ptrend=0.003), respectively. And a per 10 μmol/L increase in baseline SUA level, the risk of CKD increased by 4% (95%CI: 2%, 7%; P<0.001). The risk of CKD in the elderly with HUA at baseline was 2.00 times (95%CI: 1.20, 3.24; P=0.007) higher than that in the elderly without HUA. The results of Pearson linear correlation analysis showed that changes in eGFR in the elderly (r = -0.355, P<0.001) decreased with the increase of change in SUA level. Multivariate adjusted linear regression analysis result showed that for per 10 μmol/L increase change in SUA level, change in eGFR decreased by 1.03 (95%CI: -1.23, -0.83; P<0.001) ml/min/1.73m2. Conclusion Elevated SUA level are associated with an increased risk of CKD and a decline in eGFR in an elderly Chinese population.
Subjects: Medicine, Pharmacy >> Clinical Medicine submitted time 2023-01-03 Cooperative journals: 《中国全科医学》
Abstract：
Background The chronic kidney disease (CKD) seriously harms the health and the life span of the elderly. Hypertension is closely related to CKD. However, there are few cohort studies focusing on the blood pressure levels and CKD in the older adults. Objective To investigate the relationship between blood pressure and the risk of chronic kidney disease in the elderly aged 65 years and older. Methods Based on the "Chinese Longitudinal Healthy Longevity Survey (CLHLS)", 989 elderly people who underwent physical examination and biomedical indicator tests in 2012 were selected as subjects. Biomedical indicators including age, sex, height, weight, blood pressure, blood lipid, blood glucose and urine test were collected at baseline. The follow-up monitoring was conducted in 2014. Cox proportional hazard model was used to analyze the association between different blood pressure levels and the risk of CKD. Results 989 subjects, with an average age of 80.2±12.0 years, were included in the study. A total of 183 cases of CKD were diagnosed during an average follow-up time of 2.07 years. The cumulative incidence of CKD during the follow-up period was 18.5% (95%CI: 16.1%-21.1%), and the incidence density was 89.4/1000 person-years. Compared with normal blood pressure, older adults with hypertension, after adjusting for multiple factors, had a higher risk of CKD [HR (95%CI) 2.28 (1.13-4.60)]. The risk of CKD in older adults with baseline SBP ≥ 140mmHg was 1.83 times higher than that in older adults with SBP<120mmHg (95%CI: 1.02-3.29). The risk of CKD with baseline DBP ≥ 90mmHg was 1.55 times higher than those with DBP<80mmHg (95%CI: 1.02-2.35). Conclusion Elevated blood pressure is an independent risk factor for chronic kidney disease in the elderly. To increase screening and prevention of CKD is particularly important, especially for those with elevated systolic blood pressure.
Subjects: Geosciences >> Geography submitted time 2021-04-23 Cooperative journals: 《干旱区研究》
Abstract：以内蒙古荒漠区短脚锦鸡儿灌木为研究对象，采用野外调查法分析灌丛对植物群落的影响，采用传统培养法，结合分子鉴定法分析灌丛对土壤微生物群落的影响。结果表明：（1）灌丛内植物群落多度和总生物量显著大于灌丛外，但是物种丰度和Shannon-Wiener指数灌丛内外无显著差异；（2）随土壤深度的增加，表层土与深层土的土壤可培养细菌丰度和真菌多度差异不显著，其余土壤微生物群落多样性特征均表现为：表层土显著大于深层土；（3）灌丛对土壤微生物群落具有正效应，且表层土正效应最大；（4）灌丛对植物群落的促进作用大于对土壤微生物群落的作用。
Subjects: Geosciences >> Other Disciplines of Geosciences submitted time 2019-09-11 Cooperative journals: 《干旱区研究》
Abstract：为了验证SRM（snowmelt-runoff model）融雪径流模型在寒旱区草原流域的适用性，在阐述模型结构、参数意义的基础上，结合锡林河流域上游2014—2016年融雪期（3—5月）的MODIS积雪覆盖数据及实测气象、水文资料，采用WinSRM 1.10版本对2014—2016年锡林河上游年融雪期的径流进行模拟，结果发现：SRM模型可以较好地反映锡林河融雪期径流变化趋势，有效捕捉融雪径流洪峰到达日期及洪峰流量。对模型进行精度评价，得出3 a模拟值的拟合优度确定系数（R2）与体积差（DV）均优于世界气象组织公布的模型模拟精度均值。所以，SRM融雪径流模型在锡林河流域上游具有较好的适用性，这对合理利用草原冰雪水资源具有重要意义。
Subjects: Geosciences >> Other Disciplines of Geosciences submitted time 2019-09-10 Cooperative journals: 《干旱区研究》
Abstract：利用1958年航片和1976年、1987年、1998年、2006年和2015年5期遥感影像解译数据，运用ArcGIS软件提取矢量化数据，对玛纳斯河流域近57 a的土地利用/覆被变化进行分析。结果表明:① 玛纳斯河流域土地利用/覆被在1958—2015年发生了普遍变化，耕地、未利用地和建筑用地的面积不断增加，占流域总面积的比例分别为15.27%、4.6%和1.53%；而草地、林地和水域不断减少，减少面积占流域总面积的比例分别为13.5%、5.3%和2.55%。② 土地利用动态变化分析表明，玛纳斯河流域近57 a变化速度最快的是建筑用地，年变化率占流域总面积的12.37%；其次是耕地，年变化率占流域总面积的6.01％；此外，未利用地、林地、草地和水域的年变化率分别为0.21%、-0.99%、-0.54%和-1.39%。③ 土地利用变化改变了该流域的景观格局，导致景观结构破碎化。1958—2015年耕地、草地和未利用地的斑块数增加最多，分别增加了8.50×105个、6.54×105个和2.68×105个；而平均斑块面积（MPS）却在不断减小，分别减小1.83 km2、26.11 km2和20.26 km2，其中耕地和草地破碎化增加。玛纳斯河流域土地利用/覆被变化的分析对于深入揭示流域土地利用变化的内部机制，促进流域水土资源的合理开发和维持地区生态安全具有重要的意义。
Subjects: Computer Science >> Integration Theory of Computer Science submitted time 2018-06-19 Cooperative journals: 《计算机应用研究》
Abstract： Aiming at the problem that it is difficult for the traditional fault diagnosis method to extract effective features from QAR data, this paper proposed a dual-channel fusion model, CNN-LSTM, which combines the Convolutional Neural Network(CNN) and the Long Short-Term Memory(LSTM) . Respectively as two channels, CNN and LSTM fused through the attention mechanism to make the model able to simultaneously express the features of the data in both space dimension and time dimension and verified the validity of the feature extraction of the fusion model through time series prediction. Results of the experiment show that when compared with single CNN or LSTM, the dual-channel fusion model can extract data features more effectively, make the errors of both single-step prediction and multi-step prediction reduce by an average of 35.3%, and provide a new research idea for fault diagnosis based on QAR data.
Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2017-12-07 Cooperative journals: 《南方医科大学学报》
Abstract： Objective To determine whether the miRNA expression profile in peripheral blood mononuclear cells (PBMCs) differs between liver transplant recipients with long-term stable survival and those with acute rejection. Methods Twenty-nine liver transplant recipients with long-term stable survival (STA) group, 10 recipients with acute rejection (RJ group), and 17 healthy subjects (control group) were recruited for genome-wide microarray analysis of miRNA expressions in the PBMCs. The differentially expressed miRNAs among the 3 groups were validated by real-time PCR, and the targets of these miRNAs were predicted. Results Compared with the RJ group, the STA group showed down-regulation of 13 miRNAs in the PBMCs. Of these down-regulated miRNAs, miRNA-18b, miRNA-340 and miRNA-106b were validated by real-time PCR, and the latter two miRNAs were predicted to target the TGF-β pathway. Conclusions The differentially expressed miRNAs in liver transplant recipients with long-term stable survival, namely miRNA-18b, miRNA-340 and miRNA-106b, can be potential clinical biomarkers to predict the outcomes of liver transplantation.
Subjects: Dynamic and Electric Engineering >> Engineering Thermophysics submitted time 2017-11-07 Cooperative journals: 《工程热物理学报》
Abstract：为了探究磺化聚苯醚}SPPO)用于质子交换膜燃料电池(}PEMFOs)的性质，我们研究了SPPO膜内部水和水合氢离子的分子扩散特性。构建含水量不同的SPPO膜的分子结构模型，采用分子动力学(IVID)研究了平衡态模型的静态结构，发现元胞的密度随着含水量的增加而降低;同时通过分析径向分布函数(RDF)，发现在SPPO链上的磺酸根上的硫原子周围有水分子聚集，起到吸水和传导的作用，水合氢离子也更趋向于聚集在磺酸根附近。通过对分子运动轨迹的分析，计算了水和水合氢离子在SPPO膜内的扩散系数D和电导率。，研究结果表明，SPPO膜的电导率随着膜内水含量的增加而增加，得到了与实验符合较好的结果。
Subjects: Materials Science >> Materials Science (General) submitted time 2017-03-31 Cooperative journals: 《腐蚀科学与防护技术》
Abstract：介绍了聚焦太阳能热发电中熔融盐应用概况和腐蚀问题，综述了熔融硝酸盐、碳酸盐、氯盐、氟盐、氢氧化物等几种太阳能热发电传热储热候选熔盐腐蚀研究现状与进展，讨论了太阳能领域熔盐腐蚀研究存在的主要问题及进一步的研究方向。
Subjects: Physics >> Condensed Matter: Structural, Mechanical and Thermal Properties submitted time 2017-03-26
Abstract：应用数字化技术对核谱学测量中的探测器输出信号进行处理,特别是针对高效率闪烁体探测器输出的时间信号,利用数字化单元的多ADC交错采集、多条件触发等方法实现了时间谱测量中伽马射线的高效率采集、快速响应触发和高分辨定时等信号的数字化处理.通过研究典型的时间信号——22Na放射源衰变放出的正电子湮没前后的伽马信号,对探测器探测到的脉冲信号下降沿进行符合甄别和时间差计算等相应算法处理,实现核电子学信号处理方法中时幅转换、多道计数等核谱学时间谱符合测量模块的多信号数字化处理.
Peer Review Status:
Awaiting Review
Subjects: Physics >> Condensed Matter: Structural, Mechanical and Thermal Properties submitted time 2017-03-26
Abstract：稀土三价钐离子掺杂不同基质发光材料由于在照明、显示器件、激光等许多领域都具有广泛的应用前景而受到广泛关注并得到深入研究.本文介绍了三价钐离子的能级结构、荧光物质发光性能的影响因素及三价钐离子掺杂不同基质发光材料的发光机理和发光性能,提出了稀土荧光物质在户外领域应用时存在的问题及解决问题的途径,对荧光物质/聚合物复合材料的发展方向进行了展望.认为制备工艺简单、成本低、化学性能稳定、转光效率高的荧光物质/聚合物复合材料兼备聚合物和荧光物质二者的优点,作为一种新型的功能复合材料具有较大的市场前景.
Peer Review Status:Awaiting Review
Subjects: Physics >> Condensed Matter: Structural, Mechanical and Thermal Properties submitted time 2017-03-26
Abstract：本工作以电子辐照金红石相TiO2晶体为研究对象,以正电子湮没多普勒展宽能谱和符合多普勒展宽谱为主要的研究手段,对不同辐照参数时的空位型缺陷类型和浓度进行表征.多普勒展宽能谱测试结果表明,S参数随辐照剂量的增加先变大后变小.S-W曲线和符合多普勒的实验结果验证了Ti3+-VO复合空位的存在.
Peer Review Status:Awaiting Review
Subjects: Physics >> Condensed Matter: Structural, Mechanical and Thermal Properties submitted time 2017-03-24
Abstract：正电子湮没谱学技术是研究材料微观结构非常有效的一种特色的核谱学分析方法,主要用于获取材料内部微观结构的分布信息,特别是微观缺陷结构及其特性等传统表征方法难以获取的微观结构信息. 近年来,在慢正电子束流技术快速发展的基础上,正电子湮没谱学技术在薄膜材料表面、界面的微观结构的研究中得到了广泛的应用. 特别是正电子湮没谱学技术对空位型缺陷的高灵敏表征能力,使其在金属/合金材料表面微观缺陷的形成机制、缺陷结构特性及其演化行为等研究方面发挥了独特的优势. 针对材料内部微观缺陷形成机制、演化机理,以及缺陷特性的研究,如缺陷的微观结构、化学环境、电子密度和动量分布等,正电子湮没谱学测量方法和表征分析技术已经发展成熟. 而能量连续可调的低能正电子束流,进一步实现了薄膜材料表面微观结构深度分布信息的实验表征. 本文充分调研了慢正电子束流技术应用研究的最新进展,主要围绕北京慢正电子束流装置在金属/合金材料微观缺陷研究中,针对微观缺陷特性的表征和表面微观缺陷演化行为的应用研究成果展开综述.
Peer Review Status:Awaiting Review
Subjects: Physics >> Condensed Matter: Structural, Mechanical and Thermal Properties submitted time 2017-03-24
Abstract：有机－无机杂化膜兼具高分子膜和无机膜的特点,可克服常规分离膜遭遇的渗透性与选择性能间的trade-off问题,是一种有广泛用途的膜材料研究表明,应用正电子湮没寿命谱和正电子湮没符合多普勒展宽能谱等正电子湮没谱学技术能从微观尺度对聚合物-金属有机骨架材料杂化膜PDMS-MIL-101(Cr)的微观结构进行了表征,结果表明,随着MOFs添加量的增大,交联位置处的空位和聚合物基体的自由体积的尺寸都变小,MOFs进入了聚合物的自由体积.杂化膜的正电子湮没符合多普勒展宽能谱显示,MIL-101(Cr)亚纳米粒子的加入使得正电子在聚合物基体PDMS氧原子上的偏向湮没效应减弱,部分正电子与来自MIL-101(Cr)亚纳米粒子中金属原子的电子发生湮没,表明MOFs进入自由体积后与PDMS中的氧原子形成键,遮挡了自由体积周围的部分氧原子 .结果表明,应用正电子湮没谱学技术从微观尺度上表征有机-无机杂化膜的微观结构是非常有效的实验分析方法.
Peer Review Status:Awaiting Review
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