分类： 药物科学 >> 结构生物学 提交时间： 2024-02-29
摘要： Succinic acid, a tricarboxylic acid (TCA) cycle intermediate, significantly influences mitochondrial reactive oxygen species homeostasis through the G protein-coupled succinate receptor (SUCR1, also called GPR91), linking it to various physiological and pathological processes. Despite SUCR1’s pivotal role in mediating effects leading to liver fibrosis, hypertension, angiogenesis, inflammation, and offering a therapeutic target for multiple diseases, its activation mechanism by diverse ligands and interaction with downwards G protein remains poorly understood. This study presents the cryo-electron microscopy (cryo-EM) structures of SUCR1 in complex with inhibitory G protein (Gi) bound to succinic acid, maleic acid, and compound 31, a high-affinity agonist. These structures elucidate the distinct ligand binding modes, uncover the activation signal cascade, and detail the G protein coupling mechanism of SUCR1. Our findings provide a comprehensive structural basis for SUCR1 activation, paving the way for structure-based drug design aimed at SUCR1-related pathologies.
分类： 物理学 >> 核物理学 提交时间： 2024-02-29
Yang Jiao
Jie Liu
Pei-Xiong Zhao
Li-Hua Mo
Jin-Hu Yang
Yu-Zhu Liu
Ya-Nan Yin
Liang Wang
Qi-Yu Chen
Xiao-Yu Yan
Shi-Wei Zhao
Bo Li
You-Mei Sun
摘要： The 28nm process has a high cost-performance ratio and has gradually become the standard for the fieldof radiation-hardened devices. However, owing to the minimum physical gate length of only 35nm, the physicalarea of a standard 6T SRAM unit is approximately 0.16 μm2, resulting in a significant enhancement ofmulti-cell charge-sharing effects. Multiple-cell upsets (MCUs) have become the primary physical mechanismbehind single-event upsets (SEUs) in advanced nanometer node devices. The range of ionization track effectsincreases with higher ion energies, and spacecraft in orbit primarily experience SEUs caused by high-energyions. However, ground accelerator experiments have mainly obtained low-energy ion irradiation data. Therefore,the impact of ion energy on the SEU cross-section, charge collection mechanisms, and MCU patterns andquantities in advanced nanometer devices remains unclear. In this study, based on the experimental platformof the Heavy Ion Research Facility in Lanzhou (HIRFL), low- and high-energy heavy-ion beams were usedto study the SEUs of 28nm SRAM devices. The influence of ion energy on the charge collection processesof small-sensitive-volume devices, MCU patterns, and upset cross-sections was obtained, and the applicablerange of the inverse-cosine law was clarified. The findings of this study are an important guide for the accurateevaluation of SEUs in advanced nanometer devices and for the development of radiation-hardening techniques.
分类： 心理学 >> 应用心理学 提交时间： 2024-02-29
摘要： HPV疫苗的接种不仅能有效地阻止宫颈癌及其前期病变的发展，同时也能预防HPV感染引发的其他部位的疾病。然而我国疫苗接种情况并不乐观，许多年轻人对于接种HPV疫苗犹豫不决。基于计划理论模型，本研究旨在探究HPV疫苗接种意愿产生影响的因素，同时编制出一份具有良好信效度的HPV疫苗接种意愿影响因素重要性评估问卷，并探究不同疫苗接种意愿影响因素的重要性程度。在实验一中，本研究通过半结构化访谈的方法，探究了个体HPV疫苗接种意愿的影响因素，得到了疫苗安全性、疫苗有效性、接种便利性、专业性、从众、数据等25个影响因素；在实验二中，通过探索性因子分析、验证性因子分析及信效度检验，构建了一个包含17个题目，4个维度的HPV疫苗接种意愿影响因素重要性评估问卷。其中，验证性因子分析支持 4 因子模型（χ²/df<3，RMR=0.059，RMSEA=0.054，GFI=0.928，TLI=0.914，IFI=0.929），显示出良好的模型拟合度。问卷的 Cronbach’s α 系数为 0.853，间隔 4 周的重测信度为 0.804。表明我们的问卷具有良好的信效度。此外，个体对于不同影响因素的重要性程度评估存在明显差异，是否有家族癌症史和不同教育程度的个体在评价因素重要性时也存在显著差异。本研究将为疫苗接种推广策略提供有价值的见解，并为制定有针对性的方法提供科学依据和参考。
分类： 心理学 >> 应用心理学 分类： 计算机科学 >> 计算机应用技术 提交时间： 2024-02-29
摘要： 目的 随着网络大数据以及机器学习的方法的发展，越来越多研究结合文本分析与机器学习来预测满意度。在建立生活满意度预测模型的研究中，针对获取大量有效的有标注数据困难的问题，本研究提出基于文本数据增强以优化生活满意度预测模型。 方法 改编大连理工词典后，以357份生活现状描述为原始文本、生活满意度量表自评分为标注，经过EDA和回译进行文本数据增强，利用传统机器学习算法建立预测模型。 结果 结果显示，大连理工词典改编后，各模型预测能力大大提高；数据增强后，仅在线性回归模型上观察到回译和EDA的提升作用。使用原始数据进行训练的岭回归模型预测值与实际值的皮尔逊相关系数最高，达0.4131。 结论 特征提取精度的提升可优化目前的生活满意度预测模型，但对于以词频为特征建立的生活满意度预测模型，基于回译和EDA进行的文本数据增强可能并不十分适用。
分类： 物理学 >> 核物理学 分类： 物理学 >> 地球物理学、天文学和天体物理学 提交时间： 2024-02-29
摘要： It is hypothesized that, though atomic nuclei are made of nucleons, strongly interacting matter with baryon number from $A simeq 10^{3-9}$ to $ sim 10^{57}$ would be composed of strangeons if Nature favors always the flavor symmetry of quarks.According to that logic, strangeon matter with $A sim 10^{57}$ could manifest in the form of pulsar-like compact stars, and multi-messenger observations with advanced facilities (e.g., China’s FAST) could eventually provide a disproof/proof.It is worth emphasizing that this point of view, based on established “old physics”, may have particular consequences for understanding our material world, for both normal luminous matter and the dark sector.
分类： 心理学 >> 社会心理学 提交时间： 2024-02-28
摘要： 社交媒体上，“想回高三歇两天”的帖子屡见不鲜。为研究大学生群体对高中的怀旧心理，本研究使用问卷调查的方法，将统计分析与语料分析两种跨学科方法创新结合，提出了大学生综合怀旧得分的计算方法，并在此基础上得出了三点结论，即：（1）大学生怀旧程度在性别上男性高于女性；（2）大一学生较其他年级更不怀旧；（3）除全国Ⅰ卷地区，高中教育综合水平越高的地区，学生越怀旧。本研究还提出了八点假设，有待进一步研究，并对多种群体存在参考意义。本研究的不足在于问卷设计与数据分析方式的部分不合理，与对小概率事件的部分不正确看待。
分类： 核科学技术 >> 核科学技术其他学科 分类： 物理学 >> 核物理学 提交时间： 2024-02-28
Lei Peng
Shangming Chen
Jingyi Shi
Yongjie Sun
Yifei Liu
Yinzhong Shen
Hongya He
Huijuan Wang
Jie Tian
摘要： Ferritic/martensitic (F/M) steels have been widely used as structural material for thermal and nuclear power plants. However, it is susceptible to intergranular damage in service conditions, which is expected to be critical issues. In order to improve the intergranular damage resistance of F/M steel, thermomechanical process (TMP) was employed to achieve a grain boundary engineering (GBE) microstructure in a kind of F/M steel P92 in this study. TMP, including cold rolling to 6%, 9%, and 12% thickness reduction, respectively, followed by austenization at 1323 K for 40 min plus tempering at 1053 K for 45 min, were applied on as-received (AR) P92 steel. Both prior austenite grain (PAG) size, prior austenite grain boundary character distribution (GBCD), and the connectivity of prior austenite grain boundaries (PAGBs) were investigated. Compared with AR specimen, the PAG size does not change significantly. The fraction of coincident site lattice boundaries (CSLBs, 3 ≤ Σ ≤ 29) and Σ3n boundaries along PAGBs decreases with increasing reduction ratio due to the recrystallization fraction increases with increasing reduction ratio. The PAGBs connectivity of the 6%-deformed specimen deteriorates compared with that of AR specimen slightly. Moreover, the potentiodynamic polarization studies revealed that the intergranular damage resistance of studied steel could be improved by enhancing the fraction of CSLBs along PAGBs, indicating that TMP, involving low deformation, could enhance the intergranular damage resistance.
分类： 数学 >> 几何与拓扑 提交时间： 2024-02-28
摘要： In this paper, we study biharmonic Riemannian submersions $ pi:M^2 times r to (N^2,h)$ from a product manifold onto a surface and obtain some local characterizations of such biharmonic maps. Our results show that when the target surface is flat, then a proper biharmonic Riemannian submersion $ pi:M^2 times r to (N^2,h)$ is locally a projection of a special twisted product, and when the target surface is non-flat, $ pi$ is locally a special map between two warped product spaces with a warping function that solves a single ODE. As a by-product, we also prove that there is a unique proper biharmonic Riemannian submersion $H^2 times r to r^2$ given by the projection of a warped product.
分类： 物理学 >> 核物理学 提交时间： 2024-02-28
摘要： 介绍了上海光源线站工程之一的上海激光电子伽马源 (Shanghai Laser Electron Gamma Source, SLEGS)光束线站的建设与试运行情况，在SLEGS伽马源装置上可以开展核物理、核天体物理等基础研究、开展伽马辐照，伽马成像及伽马活化等应用研究。SLEGS光束线站在2021年12月通过工艺验收，2022年10月进入到试运行阶段，2023年9月对用户开放运行。SLEGS是国际上首台采用变换碰撞角度连续改变伽马束能量，具有最好的能量扫描精度、流强密度以及高效的能量调节能力。试运行阶段SLEGS光束线站重点解决了伽马束能谱和流强的在线监测问题，主要完成了平坦效率谱仪（FED）测量光中子截面的实验方法学研究，以及开展了伽马成像、伽马活化，正电子产生等应用平台的拓展和研究。随着逆康普顿散射技术的发展和应用需求的增加，未来短脉冲、高极化、高通量以及小型化的激光康普顿散射光源将会迎来更好的发展机遇，将在核物理、天体物理、粒子物理，极化物理，以及航空航天，医学检测，能源开发等伽马源应用研究领域发挥重要的作用。
分类： 天文学 >> 天文学 提交时间： 2024-02-28 合作期刊: 《Research in Astronomy and Astrophysics》
摘要： We tested a new model of CMOS detector manufactured by the Gpixel Inc, for potential space astronomical application. In laboratory, we obtain some bias images under the typical application environment. In these bias images, clear random row noise pattern is observed. The row noise also contains some characteristic spatial frequencies. We quantitatively estimated the impact of this feature to photometric measurements, by making simulated images. We compared different bias noise types under strict parameter control. The result shows the row noise will significantly deteriorate the photometric accuracy. It effectively increases the readout noise by a factor of 2–10. However, if it is properly removed, the image quality and photometric accuracy will be significantly improved.
分类： 天文学 >> 天文学 提交时间： 2024-02-28 合作期刊: 《Research in Astronomy and Astrophysics》
摘要： The scattered stray light of a coronagraph is a type of stray light that is generated by the objective lens as its surface defects are irradiated by sunlight. The defects mainly include dust and blemishes on the lens surface, microroughness of the lens surface, and impurity and inhomogeneity of the glass. Unlike the other types of relatively stable defects introduced when the objective lens is being manufactured, the scattered stray light caused by dusts on the lens surface is difficult to quantify accurately due to the disorder and randomness of the dust accumulation. The contribution of this type of stray light to the overall stray light level is difficult to determine through simulations and experiments. This can result in continuous deterioration of the stray light level of a coronagraph and thus affect the observation capabilities of the instrument. To solve this issue, through analyzing the forming mechanism of scattered stray light and ghost image generated by the inner-occulted coronagraph, we propose a novel method to monitor the scattered stray light from dusts by utilizing different stray light correlation coefficients. In this method, we first simulate and measure the level of stray light from the ghost image of the objective lens, and then determine the flux ratio of scattered light and ghost image on the conjugate plane. Although the flux ratio varies with the accumulation of dusts on the lens surface, it remains constant on the image plane. Therefore, the level of dust scattering light on the image plane can be obtained by using this ratio together with the level of ghost image stray light. The accuracy of this method has been validated in a laboratory by applying the objective lens with numerous surface cleanliness levels.
分类： 天文学 >> 天文学 提交时间： 2024-02-28 合作期刊: 《Research in Astronomy and Astrophysics》
摘要： The equilibrium configuration of a solid strange star in the final inspiral phase with another compact object is generally discussed, and the starquake-related issue is revisited, for a special purpose to understand the precursor emission of binary compact star merger events (e.g., that of GRB211211A). As the binary system inspirals inward due to gravitational wave radiation, the ellipticity of the solid strangeon star increases due to the growing tidal field of its compact companion. Elastic energy is hence accumulated during the inspiral stage which might trigger a starquake before the merger when the energy exceeds a critical value. The energy released during such starquakes is calculated and compared to the precursor observation of GRB211211A. The result shows that the energy might be insufficient for binary strangeon-star case unless the entire solid strangeon star shatters, and hence favors a black hole-strangeon star scenario for GRB211211A. The timescale of the precursor as well as the frequency of the observed quasi-periodic-oscillation have also been discussed in the starquake model.
分类： 天文学 >> 天文学 提交时间： 2024-02-28 合作期刊: 《Research in Astronomy and Astrophysics》
摘要： The γ-ray emitting compact symmetric objects (CSOs) PKS 1718–649, NGC 3894, and TXS 0128+554 are lobe-dominated in the radio emission. In order to investigate their γ-ray radiation properties, we analyze the ∼14 yr Fermi/LAT observation data of the three CSOs. They all show the low luminosity (1041–1043 erg s−1) and no significant variability in the γ-ray band. Their γ-ray average spectra can be well fitted by a power-law function. These properties of γ-rays are clearly different from the γ-ray emitting CSOs CTD 135 and PKS 1413+135, for which the γ-rays are produced by a restarted aligned jet. In the Lγ − Γγ plane, the three CSOs are also located at the region occupied by radio galaxies (RGs) while CTD 135 and PKS 1413+135 display a similar feature to blazars. Together with a similar radio emission property to γ-ray emitting RGs Cen A and Fornax A, we speculate that the γ-rays of the three CSOs stem from their extended mini-lobes. The broadband spectral energy distributions of the three CSOs can be well explained by the two-zone leptonic model, where their γ-rays are produced by the inverse Compton process of the relativistic electrons in extended regions. By extrapolating the observed Fermi/LAT spectra to the very high energy band, we find that TXS 0128+554 among the three CSOs may be detected by the Cherenkov Telescope Array in the future.
分类： 天文学 >> 天文学 提交时间： 2024-02-28 合作期刊: 《Research in Astronomy and Astrophysics》
摘要： GRB 200612A could be classified as an ultralong gamma-ray burst due to its prompt emission lasting up to ∼1020 s and the true timescale of the central engine activity tburst ≥ 4 × 104 s. The late X-ray light curve with a decay index of α = 7.53 is steeper than the steepest possible decay from an external shock model. We propose that this X-ray afterglow can be driven by dipolar radiation from the magnetar spindown during its early stage, while the magnetar collapsed into the black hole before its spindown, resulting in a very steep decay of the late X-ray light curve. The optical data show that the light curve is still rising after 1.1 ks, suggesting a late onset. We show that GRB 200612A's optical afterglow light curve is fitted with the forward shock model by Gaussian structured off-axis jet. This is a special case among GRBs, as it may be an ultralong gamma-ray burst powered by a magnetar in an off-axis observation scenario.
分类： 天文学 >> 天文学 提交时间： 2024-02-28 合作期刊: 《Research in Astronomy and Astrophysics》
摘要： This paper explores the correlation between the fractional variation of the ionizing continuum and C iv broad absorption lines (BALs) with different ionization levels. Our results reveal anti-correlations between fractional variation of the continuum and fractional equivalency width (EW) variation of the C iv BALs without Al iii BAL/mini-BALs at corresponding velocities, providing evidence for the widespread influence of the ionizing continuum variability on the variation of HiBALs. Conversely, for C iv BALs accompanied by Al iii BAL/mini-BALs (LoBAL groups), no significant correction is detected. The absence of such a correlation does not rule out the possibility that variations in these low-ionization lines are caused by ionizing continuum variability, but rather suggests the influence of BAL saturation to some extent. This saturation effect is reflected in the distribution of the fractional EW variation, where the C iv BAL group accompanied by Al iii BAL has a smaller standard deviation for the best-fitting Gaussian component than the two BAL groups without Al iii BAL. However, the distribution of fractional variation of their continuum does not show any significant difference. Besides the saturation influence, another potential explanation for the lack of correlations in the LoBAL groups may be the effects of other variability mechanisms besides the ionization change, such as clouds transiting across the line of sight.
分类： 天文学 >> 天文学 提交时间： 2024-02-28 合作期刊: 《Research in Astronomy and Astrophysics》
摘要： We analyze electron acceleration by a large-scale electric field E in a collisional hydrogen plasma under the solar flare coronal conditions based on approaches proposed by Dreicer and Spitzer for the dynamic friction force of electrons. The Dreicer electric field EDr is determined as a critical electric field at which the entire electron population runs away. Two regimes of strong (E ≲ EDr) and weak (E ≪ EDr) electric field are discussed. It is shown that the commonly used formal definition of the Dreicer field leads to an overestimation of its value by about five times. The critical velocity at which the electrons of the "tail" of the Maxwell distribution become runaway under the action of the sub-Dreiser electric fields turns out to be underestimated by times in some works because the Coulomb collisions between runaway and thermal electrons are not taken into account. The electron acceleration by sub-Dreicer electric fields generated in the solar corona faces difficulties.
分类： 天文学 >> 天文学 提交时间： 2024-02-28 合作期刊: 《Research in Astronomy and Astrophysics》
摘要： Remote-sensing measurements indicate that heavy ions in the corona undergo an anisotropic and mass-charge dependent energization. A popular explanation to this phenomenon is the damping of the Alfvén/ion cyclotron waves. In this paper, we propose that the ion beam instability can be an important source of the Alfvén/ion cyclotron waves, and we study the excitation of the ion beam instability in the corona at the heliocentric distance ∼3R⊙ and the corresponding energy transfer process therein based on plasma kinetic theory. The results indicate that the existence of the motionless heavy ions inhibits the ion beam instability. However, the anisotropic beams of heavy ions promote the excitation of the ion beam instability. Besides, the existence of α beams can provide a second energy source for exciting beam instability. However, when both the proton beam and the α beam reach the instability excitation threshold, the proton beam driven instability excites preferentially. Moreover, the excitation threshold of the Alfvén/ion cyclotron instability driven by ion beam is of the local Alfvén speed or even less in the corona.
分类： 天文学 >> 天文学 提交时间： 2024-02-28 合作期刊: 《Research in Astronomy and Astrophysics》
摘要： We conduct a statistical analysis of the hardness ratio (HR) for bright sources in the 4 yr Galactic Plane Scanning Survey catalog of Insight-HXMT. Depending on the stable (variable) flux Fs (Fv) or spectrum Ss(Sv) of each source, the bright sources are classified into three groups: Fv&Sv, Fv&Ss, and Fs&Ss. Our study of the HR characteristics in different types of sources reveals that accretion-powered neutron star (NS) low-mass X-ray binaries (LMXBs) exhibit softer energy spectra than NS high-mass X-ray binaries (HMXBs), but harder energy spectra than black hole binaries in most cases. This difference is probably due to their different magnetic field strengths. Additionally, Fv&Sv LMXBs tend to be harder than Fv&Ss LMXBs below 7 keV, while the opposite is true for HMXBs. Our results suggest that LMXBs may dominate unclassified sources, and NS binaries are likely to be the primary type of X-ray binaries with ambiguous compact stars. By comparing the HR of transient sources in their outburst and low-flux states, it is found that the averaged HR of four sources in the two states are roughly comparable within uncertainties. We also investigate the spatial properties of the three groups and find that Fv&Sv sources are mainly located in the longitude of −20° < l < 9°, Fv&Ss sources cross the Galactic Plane, and Fs&Ss sources are predominantly concentrated in 19° < l < 42°. In addition, analyzing the HR spatial distributions shows the absorption of soft X-rays (primarily below 2 keV) in the Galactic Plane.
分类： 天文学 >> 天文学 提交时间： 2024-02-28 合作期刊: 《Research in Astronomy and Astrophysics》
摘要： In this present study, we have analyzed different types of X-ray solar flares (C, M, and X classes) coming out from different classes of sunspot groups (SSGs). The data which we have taken under this study cover the duration of 24 yr from 1996 to 2019. During this, we observed a total of 15015 flares (8417 in SC-23 and 6598 in SC-24) emitted from a total of 33780 active regions (21746 in SC-23 and 12034 in SC-24) with sunspot only. We defined the flaring potential or flare-production potential as the ratio of the total number of flares produced from a particular type of SSG to the total number of the same-class SSGs observed on the solar surface. Here we studied yearly changes in the flaring potential of different McIntosh class groups of sunspots in different phases of SC-23 and 24. In addition, we investigated yearly variations in the potential of producing flares by different SSGs (A, B, C, D, E, F, and H) during different phases (ascending, maximum, descending, and minimum) of SC-23 and 24. These are our findings: (1) D, E, and F SSGs have the potential of producing flares ≥8 times greater than A, B, C and H SSGs; (2) The larger and more complex D, E, and F SSGs produced nearly 80% of flares in SC-23 and 24; (3) The A, B, C and H SSGs, which are smaller and simpler, produced only 20% of flares in SC-23 and 24; (4) The biggest and most complex SSGs of F-class have flaring potential 1.996 and 3.443 per SSG in SC-23 and 24, respectively. (5) The potential for producing flares in each SSG is higher in SC-24 than in SC-23, although SC-24 is a weaker cycle than SC-23. (6) The alterations in the number of flares (C+M+X) show different time profiles than the alterations in sunspot numbers during SC-23 and 24, with several peaks. (7) The SSGs of C, D, E, and H-class have the highest flaring potential in the descending phase of both SC-23 and 24. (8) F-class SSGs have the highest flaring potential in the descending phase of SC-23 but also in the maximum phase of SC-24.
分类： 天文学 >> 天文学 提交时间： 2024-02-28 合作期刊: 《Research in Astronomy and Astrophysics》
摘要： The Gaia DR3 parallax approach was used to estimate the absolute parameters of 2375 δ Scuti stars from the ASAS catalog. The selected stars have a variety of observational characteristics, with a higher than 80% probability of being δ Scuti stars. We have displayed all the stars in the Hertzsprung–Russell diagram along with the δ Scuti instability strip, the Zero Age Main Sequence and the Terminal Age Main Sequence. Then, we determined which fundamental and overtone modes each star belongs to using pulsation constant (Q) calculations. In addition, we evaluated the parameters in the Q calculation equation using three machine learning methods, which showed that surface gravity and temperature have the greatest effect on its calculation. The Period–Luminosity (P-L) relationship of the δ Scuti stars was also revisited. Eventually, using least squares linear regression, we made four linear fits for fundamental and overtone modes and updated their relationships.
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